Dna sequence specificity of antitumor agents: Oncogenes as possible targets for cancer therapy

Acta Oncologica

Volumn 27, Issue 5, 1988, Pages 503-510

  Hartley, J A ^a   Lown, J W ^a   Mattes, W B ^a   Kohn, K W ^a,b,c  

^a UNIVERSITY OF ALBERTA   (Canada)

^b NATIONAL CANCER INSTITUTE   (United States)

^c Stauffer Chemical Company ^*  (United States)

Author keywords

Chemotherapy; DNA sequence specificity; Oncogenes

Indexed keywords

ANTINEOPLASTIC AGENT; CHLORAMBUCIL; CHLORMETHINE; CONGOCIDINE; CYCLOPHOSPHAMIDE; DISTAMYCIN A; MELPHALAN; MEPACRINE MUSTARD; URAMUSTINE;

DNA SEQUENCE; DRUG SPECIFICITY; DRUG TARGETING; HEREDITY; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL;

ALKYLATING AGENTS; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; DISTAMYCINS; DNA; HUMANS; NETROPSIN; NITROGEN MUSTARD COMPOUNDS; ONCOGENES;

EID: 0024234836     PISSN: 0284186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/02841868809093578     Document Type: Article

References (31)

1. DNA sequence and expression of the B95–8 Epstein-Barr virus genome
2. The mosaic genome of warm-blooded vertebrates
3. Variation of DNA sequence specificity of DNA-oligopeptide binding ligands related to netropsin. Imidazole containing lexitropsins
4. Long term remissions following one and two dose chemotherapy for African lymphoma
5. Differences in thein vivo alkylation and crosslinking of nitrogen mustard sensitive and resistant lines of Lettre-Ehrlich ascites tumors
6. Base sequence and helix structure variations in B and A DNA
7. Nucleotide sequence and characterization of the 57′-flanking region of the rat Ha-ras protooncogene
8. DNA damage and repair in mouse leukaemia L1210 cells treated with nitrogen mustard, 1,3 Bis(2-chloroethyl)-1-nitrosourea, and other nitrosoureas
9. Bidirectional SV40 transcription mediated by tandem Spl binding interactions
10. The biological action and therapeutic applications of the B-chloroethylamines and sulfides
11. Distamycin A and netropsin
12. DNA sequence selectivity of guanine-N7 alkylation by three antitumor chloroethylating agents
13. DNA sequence selectivity of guanine-N7 alkylation by antitumor drugs and the implication of oncogene sequences as possible chemotherapeutic targets
14. Significant potential secondary structure in the Epstein-Barr virus genome
15. Molecular recognition between oligopeptides and nucleic acids. Monocationic imidazole lexitropsins that display enhanced GC sequence dependent DNA binding
16. Mechanisms of DNA sequence selective alkylation of guanine-N7 positions by nitrogen mustards
17. The molecular origin of DNA-drug specificity in netropsin and distamycin
18. The electrostatic field of B DNA
19. 1H-MNR studies
20. 1H-NMR
21. Sequence specific molecular recognition of a monocationic lexitropsin to the decadeoxyribonucleotide d[CATGGCCATG]2: Structural and dynamic aspects deduced from high field NMR studies
22. Molecular recognition between oligopeptides and nucleic acids: Influence of van der Waals contacts in determining the 37′-terminus of DNA sequences read by monocationic lexitropsins
23. Molecular recognition between oligopeptides and nucleic acids. Novel imidazole-containing oligopeptides related to netropsin that exhibit altered DNA sequence specificity
24. DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards
25. Mechanism of DNA strand breakage by piperidine at sites of N7-alkyl guanines
26. Sequencing end-labelled DNA with base-specific chemical cleavages
27. Molecular electrostatic potential of the nucleic acids
28. Cis-diamminedichloroplatinum (II) binds in a unique manner to oligo (dG). oligo (dC) sequences in DNA—a new assay using exonuclease III
29. Gene distribution and nucleotide sequence organization in the human genome
30. Burkitt's lymphoma
31. Influence of nucleotide sequence on dAdT-specific binding of netropsin to double stranded DNA