Synthetic GPI as a candidate anti-toxic vaccine in a model of malaria

Nature

Volumn 418, Issue 6899, 2002, Pages 785-789

  Schofield, Louis ^a   Hewittt, Michael C ^b   Evans, Krystal ^a   Slomos, Mary Anne ^a   Seeberger, Peter H ^b  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; AROMATIC COMPOUNDS; PATHOLOGY; PHOSPHATES; PULMONARY DISEASES; SYNTHESIS (CHEMICAL); VACCINES;

PATHOGENESIS;

MALARIA CONTROL;

ANTIBODY; GLYCOSYLPHOSPHATIDYLINOSITOL; GLYCOSYLPHOSPHATIDYLINOSITOL ANTIBODY; MALARIA VACCINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

MALARIA;

ACIDOSIS; ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MALARIA; CONTROLLED STUDY; LUNG EDEMA; MALARIA; MOUSE; NONHUMAN; PARASITEMIA; PATHOGENESIS; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN DOMAIN;

ANIMALIA; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; RODENTIA;

EID: 0037102205     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature00937     Document Type: Article

References (30)

1. World Health Organization World malaria situation 1990
2. Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites
3. Glycosylphosphatidylinositol toxin of Trypanosoma brucei regulates IL-1α and TNF-α expression in macrophages by protein tyrosine kinase mediated signal transduction
4. Glycosylphosphatidylinositol toxin of Plasmodiumu upregulates intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin expression in vascular endothelial cells and increases leukocyte and parasite cytoadherence via tyrosine kinase-dependent signal transductlon
5. Glycosylphosphatidylinositol toxin of plasmodium induces nitric oxide synthase expression in macrophages and vascular endothelial cells by a protein tyrosine kinase-dependent and protein kinase C-dependent signalling pathway
6. Signal transduction in macrophages by glycosylphosphatidylinositols of Plasmodium, Trypanosoma and Leishmania: Activation of protein tyrosine kinases and protein kinase C by inositolglycan and diacylglycerol moieties
7. Tumor necrosis factor and disease severity in children with falciparum malaria
8. An immunohistochemical study of the pathology of fatal malaria. Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration
9. The glycosyl-inositol-phosphate and dimyristoylglycerol moieties of the glycosylphosphatidylinositol anchor of the trypanosome variant-specific surface glycoprotein are distinct macrophage-activating factors
10. Highly purified glycosylphosphatidylinositols from Trypanosoma cruzi are potent proinflammatory agents
11. Sull' infezione malarica
12. Apparent lack of N-glycosylation falciparum
13. Studies oil O-glycans of Plasmodium falciparum-infected human erythrocytes: Evidence for O-GlcNAc and O-GlcNAc-transferase in malaria parasites
14. Conservation of structure among glycosylphosphatidyliositol toxins from different geographic isolates of Plasmodium falciparum
15. Glycosylphosphatidylinositol anchors represent the major carbohydrate modification in proteins of intraerythrocytic stage Plasmodium falciparum
16. Glycosylphosphatidylinositols synthesized by asexual erythrocytic stages of the malarial parasite, Plasmodium falciparum. Candidates for plasmodial glycosylphosphatidylinositol membrane anchor precursors and pathogenicity factors
17. The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes
18. The pathophysiology of malaria
19. Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria
20. Monoclonal antibody against interferon γ can prevent experimental cerebral malaria and its associated overproduction of tumour necrosis factor
21. Late administration of monoclonal antibody to leukocyte function-antigen 1 abrogates incipient murine cerebral malaria
22. Cytokine profile suggesting that murine cerebral malaria is an encephalitis
23. CD8(+)-T-cell depletion ameliorates circulatory shock in Plasmodium berghei-infected mice
24. The pathogenic basis of malaria
25. Cerebral malaria: The contribution of studies in animal models to our understanding of immunopathogenesis
26. The mechanism of immunity against malaria in communities living under hyperendemic conditions
27. A summary of our present knowledge of the mechanism of immunity in malaria
28. Effects of heavy and repeated malarial infections on Gambian infants and children
29. Glycosylphosphatidylinositol anchors of Plasmodium falciparum: Molecular characterization and naturally elicited antibody response that may provide immunity to malaria pathogenesis
30. Selective primary health care: Strategies for control of disease in the developing world. XXII. Tetanus: A preventable problem