Inhibition of interleukin-12 production in lipopolysaccharide-activated macrophages by curcumin

European Journal of Pharmacology

Volumn 384, Issue 2-3, 1999, Pages 191-195

  Kang, Bok Yun ^a   Chung, Su Wol ^a   Chung, Woon Jae ^a   Im, Suhn Young ^a   Hwang, Seung Yong ^b   Kim, Tae Sung ^a  

^a Chonnam National University   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

Curcumin; Interleukin 12; Macrophage; Nuclear factor B

Indexed keywords

CURCUMIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; LIPOPOLYSACCHARIDE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; GENE EXPRESSION; IN VITRO STUDY; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

ANIMALS; BINDING SITES; CELL LINE; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION REGULATION; INTERLEUKIN-12; LIPOPOLYSACCHARIDES; LUCIFERASES; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED DBA; NF-KAPPA B; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RECOMBINANT FUSION PROTEINS;

EID: 0033429405     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00690-1     Document Type: Article

References (17)

1. Allen P.C., Danforth H.D., Augustine P.C. Dietary modulation of avian coccidiosis. Int. J. Parasitol. 28:1998;1131-1140.
2. Ausubel F.M., Brent R., Kingston R.E., Moore D.D., Seidman J.G., Smith J.A., Struhl K. Current Protocols in Molecular Biology. 1995;Greene Assoc. New York.
3. Baldwin A.S. Jr. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:1996;649-683.
4. Chan M.M., Huang H.I., Fenton M.R., Fong D. In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties. Biochem. Pharmacol. 55:1998;1955-1962.
5. D'Ambrosio D., Cippitelli M., Cocciolo M.G., Mazzeo D., Di Lucia P., Lang R., Sinigaglia F., Panina-Bordignon P. Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-κB downregulation in transcriptional repression of the p40 gene. J. Clin. Invest. 101:1998;252-262.
6. Dignam J.D., Lebovitz R.M., Roeder R.G. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1983;1475-1489.
7. Gescher A., Pastorino U., Plummer S.M., Manson M.M. Suppression of tumour development by substances derived from the diet: mechanisms and clinical implications. Br. J. Clin. Pharmacol. 45:1998;1-12.
8. Ghosh S., May M.J., Kopp E.B. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16:1998;225-260.
9. Kang K., Kubin M., Cooper K.D., Lessin S.R., Trinchieri G., Rook A.H. IL-12 synthesis by human Langerhans cells. J. Immunol. 156:1996;1402-1407.
10. Kim T.S., DeKruyff R.H., Rupper R., Maecker H.T., Levy S., Umetsu D.T. An ovalbumin-IL-12 fusion protein is more effective than ovalbumin plus free recombinant IL-12 in inducing a T helper cell type 1-dominated immune response and inhibiting antigen-specific IgE production. J. Immunol. 158:1997;4137-4144.
11. Ma X., Chow J.M., Gri G., Carra G., Gerosa F., Wolf S.F., Dzialo R., Trinchieri G. The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. J. Exp. Med. 183:1996;147-157.
12. Murphy T.L., Cleveland M.G., Kulesza P., Magram J., Murphy K.M. Regulation of interleukin 12 p40 expression through an NFκB half-site. Mol. Cell. Biol. 15:1995;5258-5267.
13. Na S.-Y., Kang B.Y., Chung S.W., Han S.-J., Ma M., Trinchieri G., Im S.-Y., Lee J.W., Kim T.S. Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NFκB. J. Biol. Chem. 274:1999;7674-7680.
14. Romagnani S. Th1 and Th2 in human diseases. Clin. Immunol. Immunopathol. 80:1996;225-235.
15. Trinchieri G. Interleukin-12: a cytokine at the interface of inflammation and immunity. Adv. Immunol. 70:1998;83-243.
16. Vlietinck A.J., De Bruyne T., Apers S., Pieters L.A. Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection. Planta Med. 64:1998;97-109.
17. Yoshimoto T., Kojima K., Funakoshi T., Endo Y., Fujita T., Nariuchi H. Molecular cloning and characterization of murine IL-12 genes. J. Immunol. 156:1996;1082-1088.