Effect of HIV on thymic function before and after antiretroviral therapy in children

Journal of Infectious Diseases

Volumn 181, Issue 4, 2000, Pages 1479-1482

  Douek, Daniel C ^a   Koup, Richard A ^a   McFarland, Richard D ^a   Sullivan, John L ^b   Luzuriaga, Katherine ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; DIDANOSINE; LAMIVUDINE; NELFINAVIR; NEVIRAPINE; PROTEINASE INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; T LYMPHOCYTE RECEPTOR; ZIDOVUDINE;

ARTICLE; CHILD; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN TISSUE; INFANT; LYMPHOCYTE COUNT; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; THYMUS FUNCTION; TREATMENT OUTCOME; VIRUS LOAD;

ANTI-HIV AGENTS; CD4 LYMPHOCYTE COUNT; CHILD; CHILD, PRESCHOOL; DRUG THERAPY, COMBINATION; FEMALE; HIV INFECTIONS; HUMANS; INFANT; MALE; THYMUS GLAND;

EID: 0034066351     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/315398     Document Type: Article

References (13)

1. 1. Rowland-Jones S. HIV infection: where have all the T cells gone? Lancet 1999; 354:5-7.
2. 2. Mackall C, Hakin F, Gress R. T cell regeneration: all repertoires are not created equal. Immunol Today 1997; 18:245-51.
3. 3. Soares MV, Borthwick NJ, Maini MK, Janossy G, Salmon M, Akbar AN. IL-7 dependent extrathymic expansion of CD45RA T cells enables preservation of a naive repertoire. J Immunol 1998; 161:5909-17.
4. 4. Steinmann G. Changes in the human thymus during aging. Curr Top Pathol 1986; 75:43-88.
5. 5. Rosenberg PS, Goedert JJ, Biggar RJ. Effect of age at seroconversion on the natural AIDS incubation distribution: Multicenter Hemophilia Cohort Study and the International Registry of Seroconverters. AIDS 1994; 8: 803-10.
6. 6. Shearer WT, Quinn TC, LaRussa P, et al. Viral load and disease progression in infants infected with human immunodeficiency virus type 1: Women and Infants Transmission Study Group. N Engl J Med 1997; 336:1337-42.
7. 7. Burke A, Anderson D, Benson W, et al. Localization of human immunodeficiency virus 1 RNA in thymic tissues from asymptomatic drug addicts. Arch Pathol Lab Med 1995; 119:36-41.
8. 8. Aldrovandi GM, Feuer G, Gao L, et al. The SCID-hu mouse as a model for HIV-1 infection. Nature 1993; 363:732-6.
9. 9. Bonyhadi ML, Rabin L, Salimi S, et al. HIV induces thymus depletion in vivo. Nature 1993; 363:728-32.
10. 10. McCune J. Thymic function in HIV-1 disease. Semin Immunol 1997; 9: 397-404.
11. 11. Douck DC, McFarland RD, Keiser PH, et al. Changes in thymic function with age and during the treatment of HIV infection. Nature 1998; 396: 690-5.
12. 12. Zhang LQ, Lewin SR, Markowitz M, et al. Measuring recent thymic emigrants in blood of normal persons and HIV-1 infected individuals before and after effective therapy. J Exp Med 1999; 190:725-32.
13. 13. Sharland M, Watkins AM, Dalgleish AG, Cammack N, Westby M. Immune reconstitution in HAART-treated children with AIDS. Lancet 1998; 352: 577-8.