Role of the thymus in pediatric HIV-1 infection

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

Volumn 18, Issue 2, 1998, Pages 95-109

  Kirschner, Denise E ^a   Mehr, Ramit ^b   Perelson, Alan S ^c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b PRINCETON UNIVERSITY   (United States)

^c LOS ALAMOS NATIONAL LABORATORY   (United States)

Author keywords

AIDS; HIV; Immunology; Mathematical modeling; Ordinary differential equations; Pediatric AIDS; Thymus

Indexed keywords

CHILDHOOD DISEASE; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MATHEMATICAL MODEL; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; THYMOCYTE; THYMUS DISEASE; VIRUS CELL INTERACTION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0032102060     PISSN: 10779450     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042560-199806010-00001     Document Type: Review

References (65)

1. Fauci AS. The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. Science 1988;239:617-22.
2. Cantor H, Weismann IL. Development and function of subpopulation of thymocytes and T lymphocytes. Prog Allergy 1976; 20:1-64.
3. Spangrude GJ, Scollay R. Differentiation of hematopoietic stem cells in irradiated mouse thymic lobes. Kinetics and phenotype of progeny. J Immunol 1990;145:3661-8.
4. Janeway CA. Thymic selection: two pathways to life and two to death. Immunity 1994;1:3-6.
5. Bonyhadi ML, Rabin L, Salimi S, et al. HIV induces thymus depletion in vivo. Nature 1993;363:728-32.
6. Su L, Kaneshima H, Bunyhadi M, et al. HIV-1-induced thymocyte depletion is associated with indirect cytopathicity and infection of progenitor cells in vivo. Immunity 1996;2:25-36.
7. Schnittman SM, Singer KH, Greenhouse JJ, et al. Thymic microenvironment induces HIV expression. Physiologic secretion of IL-6 by thymic epithelial cells up-regulates virus expression in chronically infected cells. J Immunol 1991;147:2553-8.
8. Stanley SK, McCune JM, Kaneshima H, et al. Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse. J Exp Med 1993;178:1151-63.
9. Prevot S, Audouin J, Andre-Bougaran J, et al. Thymic pseudotumorous enlargement due to follicular hyperplasia in a human immunodeficiency virus sero-positive patient. Immunohistochemical and molecular biological study of viral infected cells. Am J Clin Pathol 1992;97:420-5.
10. Hays EF, Uittenbogaart CH, Brewer JC, et al. In vitro studies of HIV-1 expression in thymocytes from infants and children. AIDS 1992;6:265-72.
11. Mano H, Chermann JC. Fetal human immunodeficiency virus type 1 infection of different organs in the second trimester. AIDS Res Hum Retroviruses 1991;7:83-8.
12. Meyers A, Pepe N, Cranley W, McCarten K. Decreased thymus size on chest radiography: a sign of pediatric human immunodeficiency virus infection? Pediatrics 1992;90:99-102.
13. Tanaka KE, Hatch WC, Kress Y, et al. HIV-1 infection of human fetal thymocytes. J AIDS 1992;5:94-101.
14. Kourtis AP, Ibegbu C, Nahmias AJ, et al. Early progression of disease in HIV-infected infants with thymus dysfunction. N Engl J Med 1996;335:1431-6.
15. Levy JA. Pathogenesis of HIV infection. Microbiol Rev 1993;57: 183-289.
16. Oxroby MJ. Vertically acquired HIV infection in the US. In Pizzo PA, Wilfert CM, eds. Pediatric AIDS: the challenge of HIV infection in infants, children and adolescents, 2nd ed. Baltimore: Williams & Wilkins, 1994:20-30.
17. Frederick T, Mascola L, Eller A, O'Neil L, Byers B. Progression of HIV disease among infants and children infected perinatally with HIV or through neonatal blood transfusion. Pediatr Infect Dis J 1994;13:1091-7.
18. Palumbo PE, Kwok S, Waters S, et al. Viral measurements by PCR-based assays in HIV-infected infants, J Pediatr 1995;126: 592-5.
19. Mcintosh K, Shevitz A, Zaknun D, et al. Age- and time-related changes in extracellular viral load in children vertically infected by HIV. Pediatr Infect Dis J 1996;15:1087-91.
20. Marshall C, Conway B, Allen UD, et al. Evaluation of virologic parameters as potential predictors of advanced disease in HIV-infected Canadian children, Int Conf AIDS July 7-12 11:233 (abstract no. Tu.B.193).
21. Dolfus C, Courpotin C, Jacomet C, et al. Pediatric HIV-1 infection and viral quantification [abstract Tu.B.2370. XI International Conference on AIDS, 1996;11:329.
22. + T) lymphocyte depletion. Proc Natl Acad USA 1990;87:7727-31.
23. De Rossi A, Calabro ML, Panozzo M, et al. In vitro studies of HIV-1 infection in thymic lymphocytes: a putative role of the thymus in AIDS pathogenesis. AIDS 1990;6:287-98.
24. Mehr R, Globerson A, Perelson A. Modeling positive and negative selection and differentiation processes in the thymus. J Theor Biol 1995;175:103-126.
25. Mehr R, Globerson A, Perelson A. Models for selection processes in the thymus. J Appl Sci Comput 1996;3:1-19.
26. Mehr R, Abel L, Ubezio P, Globerson A, Agur Z. A mathematical model of the effect of aging on bone marrow cells colonizing the thymus. Mech Ageing Dev 1993;67:159-72.
27. Shortman K, Egerton M, Spangrude GJ, Scollay R. The generation and fate of thymocytes. J Semin Immunol 1990;2:3-12.
28. +lymphocytes in HIV-1 infection. Nature 1995;373:123-6.
29. Westermann J, Pabst R. Distribution of lymphocyte subsets and natural killer cells in the human body. Clin Invest 1992;70:539-44.
30. Haase AT, Henry K, Zupancic M, et al. Quantitative image analysis of HIV-1 infection in lymphoid tissue. Science 1996;274: 985-9.
31. Perelson AS, Neumann AU, Markowitz M, Leonard JM, Ho DD. HIV-1 dynamics in vivo: virion clearance rate, infected cell life span, and viral generation time. Science 1996;271:1582-6.
32. Autran B, Guiet P, Raphael M, et al. Thymocyte and thymic microenvironment alterations during a systemic HIV infection in a severe combined immunodeficient mouse model. AIDS 1996;10: 717-27.
33. Grody WW, Fligiel S, F. Naeim. Thymus involution in the acquired immunodeficiency syndrome. Am J Clin Pathol 1985;84: 85-95.
34. Lafeuillade A, Poggi C, Profizi N, et al. Human immunodeficiency virus Type 1 in lymph nodes compared with plasma. J Infect Dis 1996;174:404-7.
35. Kirschner D, Webb GF. A mathematical model of combined drug therapy of HIV infection. J Theor Med 1997;1:25-34.
36. Kirschner D, Webb GF. Resistance, remission, and qualitative differences in HIV chemotherapy. Emerg Infect Dis 1997;3:273-83.
37. Hueber AO, Raposo G, He HT. Thy-1 triggers mouse thymocyte apoptosis through a bcl-2-resistant mechanism. J Exp Med 1994; 179:785-96.
38. Kubo S, Nakayama T, Furutani-Seiki M, et al. A novel form of self tolerance dictated in the thymus of transgenic mice with autoreactive TCR alpha and beta chain genes. Int Immunol 1994;6:593-602.
39. Bofill M, Janossy G, Lee CA, et al. Laboratory control values for CD4 and CD8 T lymphocytes. Clin Exp Immunol 1992;88:243-52.
40. Shearer WT, Quinn TC, LasRussa P, et al. Viral load and disease progression in infants infected with HIV-1, N Engl J Med 1997; 336:1337-42.
41. Kendall M. The Thymus Gland. London: Academic Press, 1981.
42. Cardarelli N. The Thymus in Health and Senescence, Vol. 1. Boca Raton, FL: CRC Press, 1989.
43. Salinas F, Smith L, Goodman J. Cell size distribution in the thymus as a function of age. J Cell Physiol 1972;80:339-45.
44. Tosi P, Kraft R, Luzi P, et al. Involution patterns of the human thymus: size of the cortical area as a function of age. Clin Exp Immunol 1982;47:497-504.
45. Guthrie HA. Introductory Nutrition, 6th ed. St. Louis: Times College Publishing, 1986.
46. McInney RE, Wilfert CM. Lymphocyte subsets in children younger than 2 years old: normal values in population at risk for HIV infection and diagnostic and prognostic application to infected children. Pediatr Infect Dis J 1992;11:639-44.
47. Perelson AS. Modeling the interaction of the immune system with HIV. In Castillo-Chavez C, ed. Mathematical and statistical approaches to AIDS epidemiology. Lecture notes in biomathmatics, vol. 83. New York: Springer-Verlag, 1989:350-70.
48. + T cells. Math Biosci 1993;114:81-125.
49. Wei X, Ghosh SK, Taylor ME, et al. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 1995;373:117-22.
50. McLean AR, Emery VC, Webster A, Griffiths PD. Population dynamics of HIV within an individual after treatment with zidovudine. AIDS 1991;5:485-9.
51. Phillips AN. Reduction of HIV concentration during acute infection: independence from a specific immune response. Science 1996;271:497-9.
52. Hammer JA. Die Menschen Thymus, in Gesuundt and Krankheit, Part 1. Mikrosk Anat Forsch 1926;6(suppl.):107-208.
53. + T cells from patients with human immunodeficiency virus (HIV) infection reflects rapidly progressive immunosuppression and clinical disease. Ann Intern Med 1990;113: 438-43.
54. Bryson YJ, Pang S, Wei LS, Dickover R, Diagne A, Chen IS. Clearance of HIV infection in a perinatally infected infant. N Engl J Med 1995;332:833-8.
55. Newell ML, Dunn D, De Maria A, et al. Detection of virus in vertically exposed HIV-antibody-negative children. Lancet 1966; 347:213-5.
56. Perelson AS. Two theoretical problems in immunology: AIDS and epitopes. In Cowan G, Pines D, Meltzer D, eds. Complexity: metaphors, models and reality. Reading, MA: Addison-Wesley, 1994: 185-97
57. + T-lymphocyte regeneration after intensive chemotherapy. N Engl J Med 1995;332:143-9.
58. Green-Johnson J, Wade AW, Szewczuk MS. The immunobiology of aging. In Cooper EL, Nisbet-Brown E, eds. Developmental immunology. New York: Oxford University Press, 1993:427-51.
59. + T cells and thymocytes: age-related differential effects. Mech Ageing Dev 1994;73:169-78.
60. Mehr R, Perelson A, Globerson A. Feedback regulation of T cell development in the thymus. J Theor Biol 1996;181:157-67.
61. Mehr R, Perelson AS, Fridkis-Hareli M, Globerson A. Feedback regulation of T cell development: manifestations in aging. Mech Ageing Dev 1996;19:195-210.
62. Mehr R, Perelson AS, Fridkis-Hareli M, Globerson A. Regulatory feedback pathways in the thymus. Immunol Today 1997;18:581-5.
63. Mehr R, Perelson AS. Blind homeostasis and the CD4/CD8 ratio in the thymus and peripheral blood. J Acquir Immune Defic Syndr Hum Retrovirol 1997;14:387-98.
64. Stekel DJ, Parker CE, Nowak MA. A model of lymphocyte recirculation. Immunol Today 1997;18:216-21.
65. Wolfram SA. Mathematica: a system for doing mathematics by computer. Reading, MA: Addison-Wesley, 1988.