An analysis of T cell intrinsic roles of E2a by conditional gene disruption in the thymus

Journal of Immunology

Volumn 168, Issue 8, 2002, Pages 3923-3932

  Pan, Lihua ^a   Hanrahan, Jenifer ^a   Li, Jie ^a   Hale, Laura P ^a   Zhuang, Yuan ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MATURATION; CONTROLLED STUDY; GENE DISRUPTION; KNOCKOUT MOUSE; LEUKEMOGENESIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T CELL LYMPHOMA; T LYMPHOCYTE; THYMOCYTE;

EID: 0037090164     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.8.3923     Document Type: Article

References (30)

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5. Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains
6. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
7. The helix-loop-helix gene E2A is required for B cell formation
8. B-cell-specific DNA binding by an E47 homodimer
9. A heterodimer of HEB and an El 2-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines
10. Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB
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13. Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47
14. A novel role for HEB downstream or parallel to the pre-TCR signal during αβ thymopoiesis
15. B-lymphocyte development is regulated by the combined dosage of three basic helix-loop- helix genes, E2A, E2-2, and HEB
16. High incidence of T-cell tumors in E2A-null mice and E2A/Idl double-knockout mice
17. Ectopic expression of E47 or E12 promotes the death of E2A-deficient lymphomas
18. Growth inhibition and apoptosis due to restoration of E2A activity in T cell acute lymphoblastic leukemia cells
19. Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins
20. T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination
21. Functional replacement of the mouse E2A gene with a human HEB cDNA
22. + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor
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27. E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein
28. Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors
29. Class A helix-loop-helix proteins are positive regulators of several cyclin-dependent kinase inhibitors' promoter activity and negatively affect cell growth
30. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts