Controlling lymphopoiesis with a combinatorial E-protein code

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 64, Issue , 1999, Pages 45-50

  Barndt, R J ^a   Zhuang, Y ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HELIX LOOP HELIX PROTEIN; TRANSCRIPTION FACTOR; B LYMPHOCYTE RECEPTOR; HETERODIMER; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR E2A;

B LYMPHOCYTE; CELL MATURATION; CONFERENCE PAPER; DNA BINDING; GENE CONTROL; GENE OVEREXPRESSION; GENE TARGETING; GENOTYPE; LYMPHOPOIESIS; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; TRANSCRIPTION REGULATION; ADAPTIVE IMMUNITY; ARTICLE; BONE MARROW; CELL DIFFERENTIATION; GENE REARRANGEMENT; GENETIC ANALYSIS; HUMAN; NONHUMAN; POINT MUTATION; REGULATORY T LYMPHOCYTE;

EID: 0033497901     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.1999.64.45     Document Type: Conference Paper

References (34)

1. Bain G., Gruenwald S., and Murre C. 1993. E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins. Mol. Cell. Biol. 13: 3522.
2. Bain G., Engel I., Robanus Maandag B.C., te Reile H.P.J., Voland J.R., Sharp L.L., Chun J., Huey B., Pinkel D., and Murre C. 1997. E2A deficiency leads to abnormalities in αβ T-cell development and to rapid development of T-cell lymphomas. Mol. Cell. Biol. 17: 4782.
3. Bain G., Robanus Maandag E.G., Izon D.J., Amsen D., Kruisbeek A.M., Weintraub B.C., Krop I., Schlissel M.S., Feeney A.J., van Roon M., van der Valk M., te Riele H.P.J., Berns A., and Murre C. 1994. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell 79: 885.
4. Barndt R.J., Dai M.F., and Zhuang Y. 1999. A novel role for HEB downstream or parallel to the pre-TCR signal during alpha/beta thymopoiesis. J. Immun. 163: 3331.
5. Benezra R. 1994. An intermolecular disulfide bond stabilizes E2A homodimers and is required for DNA binding at physiological temperatures. Cell 79: 1057.
6. Benezra R., Davis R.L., Lockshon D., Turner D.L., and Weintraub H. 1990. The protein Id: A negative regulator of helix-loop-helix DNA binding proteins. Cell 61: 49.
7. Blom B., Heemskerk M.H., Verschuren M.C., van Dongen J.J., Stegmann A.P., Bakker A.Q., Couwenberg F., Res P.C., and Spits H. 1999. Disruption of αβ but not of γδ T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors. EMBO J. 18: 2793.
8. Choi J.K., Shen, C.P., Radomska, H.S., Eckhardt, L.A., and Kadesch T. 1996. E47 activates the Ig-heavy chain and TdT loci in non-B cells. EMBO J. 15: 5014.
9. Engel I. and Murre C. 1999. Ectopic expression of E47 or E12 promotes the death of E2A-deficient lymphomas. Proc. Natl. Acad. Sci. 96: 996.
10. Godfrey D.I. and Zlotnik A. 1993. Control points in early T-cell development. Immunol. Today 14: 547.
11. Heemskerk M.H.M., Blom B., Nolan G., Stegmann A.P.A., Bakker A. Q., Weijer K., Res P.C.M., and Spits H. 1997. Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix-loop-helix factor Id3. J. Exp. Med. 186: 1597.
12. Hu J.-S., Olson E.N., and Kingston R.E. 1992. HEB, a helix-loop-helix protein related to E2A and 1TF2 that can modulate the DNA-binding ability of myogenic regulatory factors. Mol. Cell. Biol. 12: 1031.
13. Kadesch T. 1992. Helix-loop-helix proteins in the regulation of immunoglobin gene transcription. Immunol. Today 13: 31.
14. Kee B.L. and Murre C. 1998. Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12. J. Exp. Med. 188: 699.
15. Lassar A.B., Murre C., Davis R.L., Voronova A., Wright W.E., Baltimore D., Kadesch T., and Weintraub H. 1991. Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo. Cell 66: 305.
16. Li H.P., Sata S., Frederick J., Sun X.-H., and Zhuang Y. 1999. Impaired immune responses and B cell proliferation in mice lacking the Id3 gene. Mol. Cell. Biol. 19: 5969.
17. + cells. Eur. J. Immunol. 18: 519.
18. Murre C., McCaw P.S., and Baltimore D. 1989. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 56: 777.
19. Nielsen A.L., Pallisgaard N., Pedersen F.S., and Jorgensen P. 1992. Murine helix-loop-helix transcriptional activator proteins binding to the E-box motif of Akv murine leukemia virus enhancer identified by cDNA cloning. Mol. Cell. Biol. 12: 3449.
20. O'Riordan M. and Grosschedl R. 1999. Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A. Immunity. 11: 21.
21. Park S.T., Nolan, G.P., and Sun, X.-H. 1999. Growth inhibition and apoptosis due to restoration of E2A activity in T-cell acute lymphoblastic leukemia cells. J. Exp. Med. 189: 501.
22. Paterson D.J. and Williams A.F. 1987. An intermediate cell in thymocyte differentiation that expresses CD8 but not CD4 antigen. J. Exp. Med. 166: 1603.
23. Russell W.L., Kelly E.M., Hunsicker P.R., Bangham J.W., Maddux S.C., and Phills E.L. 1979. Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse Proc. Natl. Acad. Sci. 76: 5818.
24. Sawada S. and Littman D. 1993. A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines. Mol. Cell. Biol. 13: 5620.
25. Schlissel M., Voronova A., and Baltimore D. 1991. Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line. Genes Dev. 5: 1367.
26. Shen C.-P. and Kadesch T. 1995. B-cell-specific DNA binding by an E47 homodimer. Mol. Cell. Biol. 15: 4518.
27. Sigvardsson M., O'Riordan, M., and Grosschedl R. 1997. EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes. Immunity 7: 25.
28. Sun X.-H. 1994. Constitutive expression of the Id1 genes impairs mouse B cell development. Cell 79: 893.
29. Sun X.-H. and Baltimore D. 1991. An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers. Cell 64: 459.
30. Weintraub H., Davis R., Tapscott S., Thayer M., Krause M., Benezra R., Blackwell T.K., Turner D., Rupp R., Hollenberg S., Zhuang Y., and Lassar A. 1991. The myoD gene family: Nodal point during specification of the muscle cell lineage. Science 251: 761.
31. Van W., Young A.Z., Soares V.C., Kelley R., Benezra R., and Zhuang Y. 1997. High incidence of acute T-cell tumors in E2A-null mice and E2A/Id1 double knockout mice. Mol. Cell. Biol. 17: 7317.
32. Zhuang Y., Chen P.P., and Weintraub H. 1996. B-lymphocyte development is regulated by the combined dosage of three bHLH genes, E2A, E2-2, and HEB. Mol. Cell. Biol. 16: 2898.
33. Zhuang Y., Soriano P., and Weintraub H. 1994. The helix-loop-helix gene E2A is required for B cell formation. Cell 79: 875.
34. Zhuang Y., Barndt, R.J., Pan, L., Kelly, R., and Dai M.F. 1998. Functional replacement of the mouse E2A gene with a human HEB cDNA. Mol. Cell. Biol. 18: 3340.