Synergy between cationic lipid and co-lipid determines the macroscopic structure and transfection activity of lipoplexes

Nucleic Acids Research

Volumn 30, Issue 8, 2002, Pages 1808-1816

  Ferrari, Marilyn E ^a   Rusalov, Denis ^a   Enas, Joel ^a   Wheeler, Carl J ^a  

^a VICAL INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL GROUP; CATION; CYTOFECTIN; DYE; LIPID; LIPOPLEX; LIPOSOME; NUCLEIC ACID; PLASMID DNA; SOLVENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING ASSAY; CELL LINE; CELL TYPE; CHEMICAL COMPOSITION; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; COMPLEX FORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; FATTY ACID DESATURATION; GENETIC TRANSFECTION; IN VITRO STUDY; MEMBRANE FLUIDITY; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

EID: 0037089141     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/30.8.1808     Document Type: Article

References (51)

1. Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis
2. Cationic liposome-mediated gene transfer
3. Synthetic recombinant DNA delivery for cancer therapeutics
4. Immune response in human melanoma after transfer of an allogeneic class I major histocompatibility complex gene with DNA-liposome complexes
5. Phase I study of immunotherapy of hepatic metastases of colorectal carcinoma by direct gene transfer of an allogeneic histocompatibility antigen, HLA-B7
6. Phase I study of direct gene transfer of an allogeneic histocompatibility antigen, HLA-B7, in patients with metastatic melanoma
7. Vaxfectin enhances the humoral response to pDNA encoded antigens
8. Sodium phosphate enhances plasmid DNA expression in vivo
9. Cationic liposomes are a strong adjuvant for a DNA vaccine of human immunodeficiency virus type 1
10. Vaxfectin enhances antigen specific antibody titers and maintains Th1type immune responses to plasmid DNA immunization
11. HIV-1-specific cell-mediated immune responses induced by DNA vaccination were enhanced by mannan-coated liposomes and inhibited by anti-interferon-gamma antibody
12. Intranasal immunization of a DNA vaccine with IL-12- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens
13. DNA immunization: Effects of vehicle and route of administration on the induction of protective antiviral immunity
14. Liposome-mediated DNA vaccination
15. A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung
16. Cationic liposome-mediated gene transfer to rat salivary epithelial cells in vitro and in vivo
17. Dynamic changes in the characteristics of cationic lipidic vectors after exposure to mouse serum: Implications for intravenous lipofection
18. Lipid fusion in oligonucleotide and gene delivery with cationic lipids
19. Spatial-temporal patterns of gene expression in mouse skeletal muscle after injection of lacz plasmid DNA
20. Trends in lipoplex physical properties dependent on cationic lipid structure, vehicle and complexation procedure do not correlate with biological activity
21. Analytical methods for the characterization of cationic lipid-nucleic acid complexes
22. Structural requirements for cationic lipid mediated phosphorothioate oligonucleotides delivery to cells in culture
23. Detection of nonideal mixing of phospholipids in fluid bilayers
24. Flotillas of lipid rafts fore and aft
25. Hydration of lipoplexes commonly used in gene delivery: Follow-up by laurdan fluorescence changes and quantification by differential scanning calorimetry
26. Evidence of interlipidic ion-pairing in anion-induced DNA release from cationic amphiphile-DNA complexes. Mechanistic implications in transfection
27. Control of the depth of molecules within membranes by polar groups: Determination of the location of anthracene-labeled probes in model membranes by parallax analysis of nitroxide-labeled phospholipid induced fluorescence quenching
28. Electrostatic parameters of cationic liposomes commonly used for gene delivery as determined by 4-heptadecyl-7-hydroxycoumarin
29. Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations
30. Surface charge markedly attenutates the non-lamellar phase-forming propensities of lipid bilayer membranes: Calorimetric and (31)P-nuclear magnetic resonance studies of mixtures of cationic, anionic and zwitterionic lipids
31. Probing DNA-cationic lipid interactions with the fluorophore trimethylammonium diphenyl-hexatriene (TMADPH)
32. Isothermal titration calorimetric analysis of the interaction between cationic lipids and plasmid DNA
33. Structural and functional analysis of cationic transfection lipids: The hydrophobic domain
34. Synthesis of novel cationic lipids: Effect of structural modification on the efficiency of gene transfer
35. Cellular and molecular barriers to gene transfer by a cationic lipid
36. Fusion of cationic liposomes with mammalian cells occurs after endocytosis
37. Effect of colipids in enhancing cationic lipid-mediated gene transfer in vitro and in vivo
38. Structural and fusogenic properties of cationic liposomes in the presence of plasmid DNA
39. The role of endosome destabilizing activity in the gene transfer process mediated by cationic lipids
40. Characterization of lipid DNA interactions. I. Destabilization of bound lipids and DNA dissociation
41. An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery
42. Membrane fusion plays an important role in gene transfection mediated by cationic liposomes
43. Nucleotide chain length and the morphology of complexes with cationic amphiphiles: (31)P-NMR observations
44. DNA-induced endocytosis upon local microinjection to giant unilamellar cationic vesicles
45. Gene transfer with a series of lipophilic DNA-binding molecules
46. On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids
47. Converting an alcohol to an amine in a cationic lipid dramatically alters the co-lipid requirement, cellular transfection activity and the ultrastructure of DNA-cytofectin complexes
48. Fluidity parameters of lipid regions determined by fluorescence polarization
49. Quantitative analysis of vitamin E, cholesterol and phospholipid fatty acids in a single aliquot of human platelets and cultured endothelial cells
50. Lipid composition, membrane structure relationships in lens and muscle sarcoplasmic reticulum membranes