Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses

AIDS

Volumn 16, Issue 3, 2002, Pages 321-328

  Yu, Xu G ^a   Shang, Hong ^a   Addo, Marylyn M ^a   Eldridge, Robert L ^a   Phillips, Mary N ^a   Feeney, Margaret E ^a   Strick, Daryld ^a   Brander, Christian ^a   Goulder, Philip J R ^a   Rosenberg, Eric S ^a   Walker, Bruce D ^a   Altfeld, Marcus ^a   Basgoz, N ^a   Robbins, G K ^a   Davis, B ^a   Kalams, S A ^a   Boswell, S ^a   Cohen, D S ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

CTL epitopes; Cytotoxic T lymphocytes; HIV 1; HIV 1 Gag; HLA A*0201; p15 Gag

Indexed keywords

CD8 ANTIGEN; CYTOKINE; EPITOPE; GAG PROTEIN; GAMMA INTERFERON; HLA ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; PROTEIN P15; PROTEINASE;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HOST RESISTANCE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RETROVIRUS; T LYMPHOCYTE; VIRUS ASSEMBLY;

AMINO ACID SEQUENCE; CASE-CONTROL STUDIES; CELL LINE; EPITOPE MAPPING; GENE PRODUCTS, GAG; HIV ANTIGENS; HIV INFECTIONS; HIV-1; HLA-A ANTIGENS; HUMANS; NUCLEOCAPSID PROTEINS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0037083730     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200202150-00002     Document Type: Article

References (34)

1. The role of CD4(+) T helper cells in the cytotoxic T lymphocyte response to HIV-1
2. T lymphocyte responses in HIV-1 infection: Implications for vaccine development
3. New insights into host factors in HIV-1 pathogenesis
4. Anti-HIV cellular immunity: Recent advances towards vaccine design
5. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
6. Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infection
7. Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia
8. The evolving field of HIV CRL epitope mapping: New approaches for the identification of novel epitopes
9. Role for HLA class II molecules in HIV-1 suppression and cellular immunity following antiretroviral treatment
10. The characterization of HIV-1-specific CD4+ T helper epitopes
11. HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function
12. Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children
13. Decay kinetics of human immunodeficiency virus-specific effector cytotoxic T lymphocytes after combination antiretroviral therapy
14. HIV-1 gag proteins: Diverse functions in the virus life cycle
15. New testing strategy to detect early HIV-1 infection for use in incidence estimates and for clinical and prevention purposes
16. HIV-specific cytotoxic T lymphocytes in seropositive individuals
17. Comprehensive, serologically equivalent DNA typing for HLA-8 by PCR using sequence-specific primers (PCR-SSP)
18. Long-term culture and fine specificity of human cytotoxic T-lymphocyte clones reactive with human immunodeficiency virus type 1
19. Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: Rapid characterization of CTL responses by enzyme-linked immunospot assay
20. Liver-derived CTL in hepatitis C virus infection: Breadth and specificity of responses in a cohort of persons with chronic infection
21. VPR is preferentially targeted by cytotoxic T lymphocytes during HIV-1 infection
22. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-a2 supertype peptide-binding motif
23. HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression
24. Rapid definition of five novel HLA-A*3002-restricted human immunodeficiency virus-specific cytotoxic T-lymphocyte epitopes by elispot and intracellular cytokine staining assays
25. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection
26. Allele and haplotype frequencies for HLA loci in various ethnic groups
27. Allele and haplotype frequencies for HLA and complement loci in various ethnic groups
28. Spatial proximity of the HIV-1 nucleocapsid protein zinc fingers investigated by time-resolved fluorescence and fluorescence resonance energy transfer
29. Conformational behaviour of the active and inactive forms of the nucleocapsid NCp7 of HIV-1 studied by 1H NMR
30. The central globular domain of the nucleocapsid protein of human immunodeficiency virus type 1 is critical for virion structure and infectivity
31. Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire
32. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules
33. Use of recombinant protein to identify a motif-negative human cytotoxic T-cell epitope presented by HLA-A2 in the hepatitis C virus NS3 region