Identification of dominant optimal HLA-B60- and HLA-B61-Restricted cytotoxic T-lymphocyte (CTL) epitopes: Rapid characterization of CTL responses by enzyme-linked immunospot assay

Journal of Virology

Volumn 74, Issue 18, 2000, Pages 8541-8549

  Altfeld, M A ^a   Trocha, A ^a   Eldridge, R L ^a   Rosenberg, E S ^a   Phillips, M N ^a   Addo, M M ^a   Sekaly, R P ^a   Kalams, S A ^a   Burchett, S A ^a   McIntosh, K ^a   Walker, B D ^a   Goulder, P J R ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HLA ANTIGEN CLASS 1; HLA B60 ANTIGEN;

ADULT; ARTICLE; CASE REPORT; CAUCASIAN; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE RESPONSE; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL;

ADULT; AMINO ACID SEQUENCE; CHILD; EPITOPES; GENE PRODUCTS, GAG; GENE PRODUCTS, NEF; HISTOCOMPATIBILITY TESTING; HIV ANTIGENS; HIV CORE PROTEIN P24; HIV ENVELOPE PROTEIN GP41; HIV-1; HLA-B ANTIGENS; HUMANS; IMMUNOENZYME TECHNIQUES; MOLECULAR SEQUENCE DATA; T-LYMPHOCYTES, CYTOTOXIC; VIRAL PROTEINS;

EID: 0033858745     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.18.8541-8549.2000     Document Type: Article

References (45)

1. HLA class I nucleotide sequences
2. HLA-B40, B18, B27, and B37 allele discrimination using group-specific amplification and SSCP method
3. Human histocompatibility leukocyte antigen-binding supermotifs predict broadly cross-reactive cytotoxic T lymphocyte responses in patients with acute hepatitis
4. + cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection
5. Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus
6. Recent advances in HIV-1 CTL epitope characterization, p. IV-1-IV-17
7. T lymphocyte responses in HIV-1 infection: Implications for vaccine development
8. Comprehensive, serologically equivalent DNA typing for HLA-B by PCR using sequence-specific primers (PCR-SSP)
9. HLA and HIV-1: Heterozygote advantage and B*35-Cw*04 disadvantage
10. Allele and haplotype frequencies for HLA loci in various ethnic groups
11. An antigenic peptide of the HIV-1 NEF protein recognized by cytotoxic T lymphocytes of seropositive individuals in association with different HLA-B molecules
12. Binding of a peptide antigen to multiple HLA alleles allows definition of an A2-like supertype
13. Rapid and slow progressors differ by a single MHC class I haplotype in a family of MHC-defined rhesus macaques infected with SIV
14. Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef
15. Peptide motifs of HLA-B58, B60, B61, and B62 molecules
16. Differential narrow focusing of immunodominant human immunodeficiency virus Gag-specific cytotoxic T-lymphocyte responses in infected African and Caucasoid adults and children
17. Novel, cross-restricted, conserved, and immunodominant cytotoxic T lymphocyte epitopes in slow progressors in HIV type 1 infection
18. Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS
19. Combined structural and immunological refinement of HIV-1 HLA-B8-restricted cytotoxic T lymphocyte epitopes
20. The great escape - AIDS viruses and immune control
21. Anti-HIV cellular immunity: Recent advances towards vaccine designe
22. Allele and haplotype frequencies for HLA and complement loci in various ethnic groups
23. HLA alleles determine human T-lymphotropic virus-1 (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy
24. Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques
25. HIV-1 gag-specific cytotoxic T lymphocytes recognize multiple highly conserved epitopes. Fine specificity of the gag-specific response defined by using unstimulated peripheral blood mono-nuclear cells and cloned effector cells
26. Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infection
27. Levels of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte effector and memory responses decline after suppression of viremia with highly active antiretroviral therapy
28. Three new cytotoxic T cell epitopes identified within the hepatitis C virus nucleoprotein
29. Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection
30. Consistent associations of HLA class I and II and transporter gene products with progression of human immunodeficiency virus type 1 infection in homosexual men
31. Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: A longitudinal analysis of rapid progressors and long-term asymptomatics
32. Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression
33. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
34. Serologic ambiguity and allelic frequency of the HLA-B40 family in the Korean population
35. Conserved CTL epitopes within EBV latent membrane protein 2: A potential target for CTL-based tumor therapy
36. Diversity of HLA-B61 alleles and haplotypes in East Asians and Spanish Gypsies
37. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
38. Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection
39. Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes
40. Degenerate and promiscuous recognition by CTL of peptides presented by the MHC class I A3-like superfamily: Implications for vaccine development
41. HIV-specific cytotoxic T lymphocytes in seropositive individuals
42. Long-term culture and fine specificity of human cytotoxic T-lymphocyte clones reactive with human immunodeficiency virus type 1
43. Liver-derived CTL in hepatitis C virus infection: Breadth and specificity of responses in a cohort of persons with chronic infection
44. CD8+ cells in human immunodeficiency virus type I pathogenesis: Cytolytic and noncyrolytic inhibition of viral replication