Kinetic evidence for a substrate-induced fit in phosphonoacetaldehyde hydrolase catalysis

Biochemistry

Volumn 41, Issue 45, 2002, Pages 13370-13377

  Zhang, Guofeng ^a   Mazurkie, Andrew S ^b   Dunaway Mariano, Debra ^a   Allen, Karen N ^b  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND BINDING;

ACETYLATION; CATALYSIS; ENZYME INHIBITION; HYDROLYSIS; PH EFFECTS; REACTION KINETICS; SUBSTRATES;

BIOCHEMISTRY;

2,4 DINITROPHENYLACETIC ACID; ACETALDEHYDE; HYDROLASE; LYSINE; PHOSPHONOACETALDEHYDE; PHOSPHONOACETALDEHYDE HYDROLASE; REAGENT; SCHIFF BASE; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; BACILLUS CEREUS; CATALYSIS; CHEMICAL BOND; CHEMICAL MODIFICATION; CONTROLLED STUDY; DISSOCIATION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INACTIVATION; ENZYME SUBSTRATE COMPLEX; EQUILIBRIUM CONSTANT; HYDROLYSIS; KINETICS; LIGAND BINDING; MOLECULAR STABILITY; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN DOMAIN;

ACETYLATION; AMINO ACID SEQUENCE; BACILLUS CEREUS; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HYDROGEN-ION CONCENTRATION; HYDROLASES; KINETICS; LIGANDS; LYSINE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PHENYLACETATES; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY;

BACILLUS CEREUS;

EID: 0037069406     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi026388n     Document Type: Article

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