2-Arylindoles as gonadotropin releasing hormone (GnRH) antagonists: Optimization of the tryptamine side chain

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 5, 2002, Pages 827-832

  Young, Jonathan R ^a   Huang, Song X ^a   Walsh, Thomas F ^a   Wyvratt Jr , Matthew J ^a   Yang, Yi Tien ^a   Yudkovitz, Joel B ^a   Cui, Jisong ^a   Mount, George R ^a   Ren, Rena Ning ^a   Wu, Tsuei Ju ^a   Shen, Xiaolan ^a   Lyons, Kathryn A ^a   Mao, An Hua ^a   Carlin, Josephine R ^a   Karanam, Bindhu V ^a   Vincent, Stella H ^a   Cheng, Kang ^a   Goulet, Mark T ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUND; BENZOTRIAZOLE DERIVATIVE; GONADORELIN ANTAGONIST; INDOLE DERIVATIVE; PYRIDINE DERIVATIVE; TRYPTAMINE;

ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; RAT; REDUCTION; RODENT;

ADMINISTRATION, ORAL; ANIMALS; BINDING SITES; BUSERELIN; FERTILITY AGENTS, FEMALE; GONADOTROPIN-RELEASING HORMONE; HUMANS; INDOLES; INOSITOL PHOSPHATES; LUTEINIZING HORMONE; MALE; QUINOLINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTAMINES;

RODENTIA;

EID: 0037060924     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00026-4     Document Type: Article

References (36)