Calpain-dependent neurofilament breakdown in anoxic and ischemic rat central axons

Neuroscience Letters

Volumn 328, Issue 2, 2002, Pages 150-154

  Stys, Peter K ^a   Jiang, Qiubo ^a  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

Anoxia; Calcium; Sodium channel; White matter

Indexed keywords

[1 [(1 FORMYL 2 PHENYLETHYL)CARBAMOYL] 2 METHYLPROPYL]CARBAMIC ACID BENZYL ESTER; CALCIUM ION; CALPAIN; CALPASTATIN; EGTAZIC ACID; GLUCOSE; ISOPROTEIN; NEUROFILAMENT PROTEIN; OXYGEN; TETRODOTOXIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN ISCHEMIA; CELL HYPOXIA; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOSKELETON; DRUG EFFECT; ENZYME INHIBITION; IMMUNOBLOTTING; MALE; MOLECULAR WEIGHT; NERVE CELL LESION; NERVE FIBER; NEUROFILAMENT; NEUROPROTECTION; NONHUMAN; OPTIC NERVE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; RAT; REPERFUSION; WHITE MATTER;

ACTION POTENTIALS; ANIMALS; AXONS; CALCIUM; CALCIUM SIGNALING; CALPAIN; CENTRAL NERVOUS SYSTEM; CHELATING AGENTS; ENZYME INHIBITORS; HYPOXIA-ISCHEMIA, BRAIN; MALE; NERVE DEGENERATION; NERVE FIBERS, MYELINATED; NEUROFILAMENT PROTEINS; OPTIC NERVE; ORGAN CULTURE TECHNIQUES; RATS; RATS, LONG-EVANS; RECOVERY OF FUNCTION; TETRODOTOXIN;

EID: 0037047484     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(02)00469-X     Document Type: Article

References (20)

1. A brief period of hypoxia causes proteolysis of cytoskeletal proteins in hippocampal slices
2. The role of calpain-mediated spectrin proteolysis in traumatically induced axonal injury
3. Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL 28,170
4. The calpain family and human disease
5. Calpain inhibitors confer biochemical, but not electrophysiological, protection against anoxia in rat optic nerves
6. Mechanisms of calpain proteolysis following traumatic brain injury: Implications for pathology and therapy: A review and update
7. Ischemic cell death in brain neurons
8. Elemental composition and water content of rat optic nerve myelinated axons and glial cells: Effects of in vitro anoxia and reoxygenation
9. Dephosphorylation of neurofilament proteins enhances their susceptibility to degradation by calpain
10. Initiating mechanisms involved in the pathobiology of traumatically induced axonal injury and interventions targeted at blunting their progression
11. Mu-Calpain activation, DNA fragmentation, and synergistic effects of caspase and calpain inhibitors in protecting hippocampal neurons from ischemic damage
12. Blockade of calpain proteolytic activity rescues neurons from glutamate excitotoxicity
13. E-64-d prevents both calpain upregulation and apoptosis in the lesion and penumbra following spinal cord injury in rats
14. Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain
15. Behavioral efficacy of posttraumatic calpain inhibition is not accompanied by reduced spectrin proteolysis, cortical lesion, or apoptosis
16. A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain
17. Anoxic and ischemic injury of myelinated axons in CNS white matter: From mechanistic concepts to therapeutics
18. Compound action potential of nerve recorded by suction electrode: A theoretical and experimental analysis
19. Role of extracellular calcium in anoxic injury of mammalian central white matter
20. Ultrastructural concomitants of anoxic injury and early post-anoxic recovery in rat optic nerve