Active site water molecules revealed in the 2.1 Å resolution structure of a site-directed mutant of isocitrate dehydrogenase

Journal of Molecular Biology

Volumn 295, Issue 3, 2000, Pages 377-385

  Cherbavaz, Diana B ^a   Lee, Myoung E ^b   Stroud, Robert M ^a   Koshland Jr , Daniel E ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Crystal structure; Electrostatic stabilization; IDH; K230M; Solvation

Indexed keywords

2 OXOGLUTARIC ACID; ASPARAGINE; ISOCITRATE DEHYDROGENASE; ISOCITRIC ACID; METHIONINE; MUTANT PROTEIN; WATER;

ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME STRUCTURE; MOLECULE; POINT MUTATION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; WATER CONTENT;

EID: 0034695423     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.3195     Document Type: Article

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