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Volumn 40, Issue 14, 2001, Pages 4234-4241
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Structural basis for a change in substrate specificity: Crystal structure of S113E isocitrate dehydrogenase in a complex with isopropylmalate, Mg2+, and NADP
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Author keywords
[No Author keywords available]
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Indexed keywords
LIGAND BINDING;
AMINO ACIDS;
CATALYST ACTIVITY;
ENZYMES;
HYDROGEN BONDS;
OXIDATION;
SUBSTRATES;
CRYSTAL STRUCTURE;
AMINO ACID;
ISOCITRATE DEHYDROGENASE;
ISOCITRIC ACID;
ISOPROPYL MALATE;
MAGNESIUM ION;
MALIC ACID DERIVATIVE;
NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;
UNCLASSIFIED DRUG;
AMINO ACID SEQUENCE;
AMINO ACID SUBSTITUTION;
ARTICLE;
CATALYSIS;
CONFORMATIONAL TRANSITION;
CRYSTAL STRUCTURE;
DECARBOXYLATION;
ENZYME ACTIVE SITE;
ENZYME ACTIVITY;
ENZYME CONFORMATION;
ENZYME SPECIFICITY;
ENZYME SUBSTRATE COMPLEX;
HYDROGEN BOND;
LIGAND BINDING;
MOLECULAR INTERACTION;
PRIORITY JOURNAL;
STRUCTURE ACTIVITY RELATION;
STRUCTURE ANALYSIS;
AMINO ACID SUBSTITUTION;
BINDING SITES;
CATALYSIS;
CRYSTALLOGRAPHY, X-RAY;
ESCHERICHIA COLI;
FREEZING;
GLUTAMIC ACID;
ISOCITRATE DEHYDROGENASE;
MACROMOLECULAR SUBSTANCES;
MAGNESIUM;
MALATES;
NADP;
PROTEIN STRUCTURE, SECONDARY;
PROTEIN STRUCTURE, TERTIARY;
SERINE;
STRUCTURE-ACTIVITY RELATIONSHIP;
SUBSTRATE SPECIFICITY;
TYROSINE;
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EID: 0035836524
PISSN: 00062960
EISSN: None
Source Type: Journal
DOI: 10.1021/bi002533q Document Type: Article |
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Times cited : (22)
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References (31)
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