Microtubule stability decreases axon elongation but not axoplasm production

Journal of Neuroscience

Volumn 16, Issue 10, 1996, Pages 3236-3246

  Rochlin, M William ^a   Wickline, Karen M ^b   Bridgman, Paul C ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST LOUIS CHILDREN S HOSPITAL   (United States)

Author keywords

axon; dynamic instability; growth cone; microtubule; nocodazole; polymerization

Indexed keywords

ALPHA TUBULIN; NOCODAZOLE;

ANIMAL CELL; ARTICLE; AXOPLASM; CONTROLLED STUDY; CYTOSKELETON; EMBRYO; EXPLANT; GROWTH CONE; MICROTUBULE ASSEMBLY; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; RAT; SUPERIOR CERVICAL GANGLION;

EID: 0029990387     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-10-03236.1996     Document Type: Article

References (34)

1. Ahmad FJ, Baas PW (1995) Microtubules released from the neuronal centrosome are transported into the axon. J Cell Biol 108:2761-2769.
2. Baas PW, Ahmad FJ (1992) The plus ends of stable microtubules are the exclusive nucleating structures for microtubules in the axon. J Cell Biol 116:1231-1241.
3. Baas PW, Ahmad FJ (1993) The transport properties of axonal microtubules establish their polarity orientation. J Cell Biol 120:1427-1437.
4. Baas PW, Black MM (1990) Individual microtubules in the axon consist of domains that differ in both composition and stability. J Cell Biol 111:495-509.
5. Baas PW, Slaughter T, Brown A, Black MM (1991) Microtubule dynamics in axons and dendrites. J Neurosci Res 30:134-153.
6. Bamburg JR, Bray D, Chapman K (1986) Assembly of microtubules at the tip of the growing axons. Nature 321:708-790.
7. Bray D, Bunge MB (1981) Serial analysis of microtubules of cultured rat sensory neurons. J Neurocytol 10:589-605.
8. Brown B, Li Y, Slaughter T, Black MM (1993) Composite microtubules of the axon: quantitative analysis of tyrosinated and acctylated tubulin along individual axonal microtubules. J Cell Sci 104:339-352.
9. Bridgman PC, Dailey ME (1989) The organization of myosin and actin in rapid frozen nerve growth cones. J Cell Biol 108:95-109.
10. Dailey ME, Bridgman PC (1989) Dynamics of the endoplasmic reticulum and other membranous organelles in growth cones of cultured neurons. J Neurosci 9:1897-1909.
11. Dailey ME, Bridgman PC (1992) Structure and organization of membrane organelles along distal microtubule segments in growth cones. J Neurosci Res 30:242-258.
12. 1H-benzimidazol-2-yl]carbamate (R 17934; NSC 238159), a new synthetic antitumoral drug interfering with microtubules, on mammalian cells cultured in vitro. Cancer Res 36:905-916.
13. Edson KJ, Lim S-S, Borisy GG, Letourneau PC (1993) FRAP analysis of the stability of the microtubule population along the neurites of chick sensory neurons. Cell Motil Cytoskeleton 25:59-72.
14. Gelfand VI, Bershadsky AD (1991) Microtubule dynamics: mechanism, regulation, and function. Annu Rev Cell Biol 7:93-116.
15. Gordon-Weeks PR, Lang RDA (1988) The β-tubulin of the growth cone is predominantly in the tyrosinated form. Dev Brain Res 42:156-160.
16. Gundersen GG, Bulinsky JC (1984) Distinct populations of microtubules: tyrosinated and nontyrosinated alpha tubulin are distributed differently in vivo. Cell 38:779-789.
17. Hirokawa N (1993) Axonal transport and the cytoskeleton. Curr Opin Neurobiol 3:724-731.
18. Hirokawa N (1994) Microtubule organization and dynamics dependent on microtubule-associated proteins. Curr Opin Cell Biol 6:74-81.
19. Jordan MA, Thrower D, Wilson L (1992) Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles: implications for the role of microtubule dynamics in mitosis. J Cell Sci 102:401-416.
20. Jordan MA, Wilson L (1990) Kinetic analysis of tubulin exchange at microtubule ends at low vinblastine concentrations. Biochemistry 29:2730-2739.
21. Jordan MA, Toso RJ, Thrower D, Wilson L (1993) Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations Proc Natl Acad Sci USA 90:9552-9556.
22. Joshi HC, Baas PW (1993) A new perspective on microtubules and axon growth [review]. J Cell Biol 121:1191-1196.
23. Letourneau PC, Ressler AH (1984) Inhibition of neurite initiation and growth by taxol. J Cell Biol 98.1355-1362
24. Li Y, Black MM (1996) Microtubule assembly and turnover in growing axons. J Neurosci 16:531-544.
25. Lim S-S, Sammak PJ, Borisy GG (1989) Progressive and spatially differentiated stability of microtubules in developing neuronal cells. J Cell Biol 109:253-263.
26. Lim S-S, Edson KJ, Letourneau PC, Borisy GG (1990) A test of microtubule translocation during neurite elongation. J Cell Biol 111:29-44.
27. Lin C-H, Forscher P (1993) Cytoskeletal remodeling during growth cone-target interactions. J Cell Biol 121:1369-1383.
28. Liao G, Nagasaki T, Gundersen GG (1995) Low concentrations of nocodazole interfere with fibroblast locomotion without significantly affecting microtubule level: implications for the role of dynamic microtubules in cell locomotion. J Cell Sci 108:3473-3483.
29. Mitchison T, Kirschner M (1984) Dynamic instability of microtubule growth. Nature 312:237-242.
30. Okabe S, Hirokawa N (1992) Differential behavior of photoactivated microtubules in growing axons of mouse and frog neurons. J Cell Biol 117:105-120.
31. Pryer NK, Walker RA, Skeen VP, Bourns BD, Soboeiro MF, Salmon ED (1992) Brain microtubule-associated proteins modulate microtubule dynamic instability in vitro. J Cell Sci 103:956-976.
32. Sabry JH, O'Connor TP, Evans L, Toroian-Raymond A, Kirschner M, Bentley D (1991) Microtubule behavior during guidance of pioneer neuron growth cones in situ. J Cell Biol 115:381-395.
33. Tanaka E, Kirschner MW (1991) Microtubule behavior in the growth cones of living neurons during axon elongation. J Cell Biol 115:345-363.
34. Tanaka E, Ho T, Kirschner MW (1995) The role of microtubule dynamics in growth cone motility and axonal growth. J Cell Biol 128:139-155.