Gene delivery from a DNA controlled-release stent in porcine coronary arteries

Nature Biotechnology

Volumn 18, Issue 11, 2000, Pages 1181-1184

  Klugherz, Bruce D ^a   Jones, Peter L ^b   Cui, Xiumin ^b   Chen, Weiliam ^b   Meneveau, Nicolas F ^a   DeFelice, Suzanne ^b   Connolly, Jeanne ^b   Wilensky, Robert L ^a   Levy, Robert J ^b  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Angioplasty; Drug delivery; Plasmid; Polymer; Transfection

Indexed keywords

GREEN FLUORESCENT PROTEIN; PLASMID DNA; POLYGLACTIN;

ANALYTIC METHOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA MEDIA; ARTICLE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; CORONARY STENT; DNA TRANSFECTION; DRUG DELIVERY SYSTEM; GENE TARGETING; GENE THERAPY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; SUSTAINED RELEASE FORMULATION; SWINE;

ANIMALS; BENZOTHIAZOLES; CARDIOVASCULAR DISEASES; CELLS, CULTURED; CORONARY VESSELS; DNA; ELECTROPHORESIS, AGAR GEL; FLUORESCENT DYES; GENE TRANSFER TECHNIQUES; GREEN FLUORESCENT PROTEINS; IMMUNOHISTOCHEMISTRY; KINETICS; LUMINESCENT PROTEINS; MALE; MUSCLE, SMOOTH; PLASMIDS; POLYMERASE CHAIN REACTION; QUINOLINES; RATS; STENTS; SWINE; THIAZOLES; TIME FACTORS; TRANSFECTION;

ANIMALIA; SUIDAE; SUS SCROFA;

EID: 0033758080     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/81176     Document Type: Article

References (26)

1. A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease. Benestent Study Group
2. A randomized comparison of coronary-stent placement and balloon angioplasty in the treatment of coronary artery disease. Stent Restenosis Study Investigators
3. Histopathologic comparison of human coronary in-stent and post-balloon angioplasty restenotic tissue
4. Adenoviral vector-mediated gene transfer into sheep arteries using a double-balloon catheter
5. A new cationic liposome DNA complex enhances the efficiency of arterial gene transfer in vivo
6. Cytostatic gene therapy for Vascular proliferative disorders with a constitutively active form of the retinoblastoma gene product
7. Regulation of cellular proliferation and intimal formation following balloon injury in atherosclerotic rabbit arteries
8. Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo
9. Pharmacokinetics of antisense oligodeoxyribonucleotides (cyclin B1 and CDC 2 kinase) in the vessel wall in vivo: Enhanced therapeutic utility for restenosis by HVJ-liposome delivery
10. Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty
11. Effects of antisense c-myb oligonucleotides on vascular smooth muscle cell proliferation and response to vessel wall injury
12. Expression and function of a recombinant endothelial nitric oxide synthase gene in porcine coronary arteries
13. Fas ligand gene transfer to the vessel wall inhibits neointima formation and overrides the adenovirus-mediated T cell response
14. Adenovirus-mediated delivery of Fas ligand inhibits intimal hyperplasia after balloon injury in immunologically primed animals
15. Antisense oligonucleotide inhibition of PDGFR-beta receptor subunit expression directs suppression of intimal thickening
16. A DNA controlled-release coating for gene transfer: Transfection in skeletal and cardiac muscle
17. Gene transfection using biodegradable nanospheres: Results in tissue culture and a rat osteotomy model
18. Localized, direct plasmid gene delivery in vivo: Prolonged therapy results in reproducible tissue regeneration
19. DNA delivery from polymer matrices for tissue engineering
20. Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy
21. Marked inflammatory sequelae to implantation of biodegradable and nonbiodegradable polymers in porcine coronary arteries
22. Sustained local delivery of dexamethasone by a novel intravascular eluting stent to prevent restenosis in the porcine coronary injury model
23. Elution of DNA from agarose gels after electrophoresis
24. Bis-intercalation of homodimeric thiazole orange dye derivatives in DNA
25. Improved cationic lipid formulations for in vivo gene therapy
26. Polymerase chain reaction cloning of related genes