Cyclosporin A in blood and brain tissue following intra-carotid injections in normal and stroke-induced rats

Brain Research

Volumn 943, Issue 1, 2002, Pages 1-8

  Vachon, Pascal ^a,b   Beaudry, Francis ^a   Marier, Jean Francois ^a,b   Ste Marie, Line ^c   Montgomery, Jane ^c  

^a MDS Inc   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Cyclosporin A; Focal cerebral ischemia; Neuroprotection; Pharmacokinetics

Indexed keywords

CYCLOSPORIN A;

ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; CAROTID ARTERY OBSTRUCTION; CAVA VEIN; COMMON CAROTID ARTERY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; EXTERNAL CAROTID ARTERY; HEMISPHERE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY;

ANIMALS; BRAIN; CAROTID ARTERY, COMMON; CEREBROVASCULAR ACCIDENT; CYCLOSPORINE; INFARCTION, MIDDLE CEREBRAL ARTERY; INJECTIONS, INTRA-ARTERIAL; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0037024967     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)02413-7     Document Type: Article

References (34)

1. Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats
2. Permeability of the blood-brain barrier to the immunosuppressive cyclic peptide Cyclosporin A
3. Physiologic modeling of cyclosporin kinetics in rat and man
4. Neuroprotective actions of FK506 in experimental stroke: In vivo evidence against an antiexcitotoxic mechanism
5. Restrictive transport of a lipid-soluble peptide (cyclosporin) through the blood-brain barrier
6. Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity
7. Cyclosporin, but not FK506, protects mitochondria and neurons against hypoglycemia damage and implicates the mitochondrial permeability transition in cell death
8. Apoptosis in neuronal cells: Role of caspases
9. Quantitative analysis of cerebral microvascular hemodynamics with T2-weighted dynamic MR imaging
10. The immunosuppressants cyclosporine A and FK506 equally ameliorate brain damage due to 30-min middle cerebral artery occlusion in hyperglycemic rats
11. Pharmacokinetic changes of cyclosporin after intravenous and oral administration to rats with uranyl nitrate-induced acute renal failure
12. Influence of blood components on the tissue uptake indices of cyclosporin in rats
13. Effects of intracarotid arterial injection of Cyclosporin A and spontaneous hypothermia on brain damage incurred after a long period of global ischemia
14. Cyclosporin enhances survival, ameliorates brain damage, and prevents secondary mitochondrial dysfunction after a 30-minute period of transient cerebral ischemia
15. Calcineurin is a common target of cyclophilin-cyclosporin A and FkBP-FK506 complexes
16. Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion
17. The role of lipoproteins in exchange and transfer of cyclosporin - Results from in vitro investigations
18. Distribution and transfer of cyclosporin among the various human lipoprotein classes
19. Release of cytochrome c from mitochondria to cytosol in gerbil hippocampal CA1 neurons after transient forebrain ischemia
20. Cyclosporin A delays mitochondrial depolarization induced by N-methyl-D-aspartate in cortical neuron: Evidence of the mitochondrial permeability transition
21. Mitochondrial porin required for ischemia-induced mitochondrial dysfunction and neuronal damage
22. In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of Cyclosporin A at the blood-brain barrier
23. Cyclosporin A protects against ischemia-reperfusion in the brain
24. Transport of Cyclosporin A across the brain capillary cell monolayer by P-glycoprotein
25. Hydroxyl radical production in the cortex and striatum in a rat model of focal cerebral ischemia
26. Decrease in oral bioavailability of Cyclosporin A by coadministration of probucol in rats
27. Cyclosporin A attenuates acute mitochondrial dysfunction following traumatic brain injury
28. Focal cerebral ischemia in the rat: Description of technique and early neuropathological consequences following middle cerebral artery occlusion
29. Physiologically based pharmacokinetics of Cyclosporin A: Reevaluation of dose-non-linear kinetics in rats
30. Dose-dependent pharmacokinetics of Cyclosporin A in rats: Events in tissues
31. Amelioration of Cyclosporin A of brain damage in transient forebrain ischemia in the rat
32. Posttreatment with the immunosuppressant Cyclosporin A in transient focal ischemia
33. Cyclosporin A-sensitive changes in mitochondrial glutathione are early response to intrastriatal NMDA or forebrain ischemia in rats
34. Injected cytochrome c induces apoptosis