Cyclosporin A-sensitive changes in mitochondrial glutathione are an early response to intrastriatal NMDA or forebrain ischemia in rats

Journal of Neurochemistry

Volumn 73, Issue 5, 1999, Pages 2214-2217

  Zaidan, Emad ^a   Nilsson, Michael ^b   Sims, Neil R ^a,c  

^a FLINDERS UNIVERSITY   (Australia)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c FLINDERS UNIVERSITY   (Australia)

Author keywords

Cyclosporin A; Excitotoxicity; Glutathione; Ischemia; Mitochondria; Mitochondrial permeability transition

Indexed keywords

CYCLOSPORIN A; GLUTATHIONE; N METHYL DEXTRO ASPARTIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN MITOCHONDRION; CONTROLLED STUDY; DRUG MECHANISM; GLUTATHIONE METABOLISM; MALE; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0032720041     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.02214.x     Document Type: Article

References (24)

1. Booth R. F. G. and Clark J. B. (1979) A method for the rapid separation of soluble and particulate components of rat brain synaptosomes. FEBS Lett. 107, 387-392.
2. Brown M. R. and Hedge G. A. (1972) Thyroid secretion in the unanaesthetised, stress-free rat and its suppression by pentobarbital. Neuroendocrinology 9, 158-174.
3. Friberg H., Ferrand-Drake M., Bengtsson F., Halestrap A. P., and Wieloch T. (1998) Cyclosporin A, but not FK-506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death. J. Neurosci. 18, 5151-5159.
4. Halestrap A. P., Kerr P. M., Javadov S., and Woodfield K.-Y. (1998) Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart. Biochim. Biophys. Acta 1366, 79-94.
5. Huang J. and Philbert M. A. (1995) Distribution of glutathione and glutathione-related enzyme systems in mitochondria and cytosol of cultured cerebellar astrocytes and granule cells. Brain Res. 680, 16-22.
6. 2 in vitro. Brain Res. 680, 16-22.
7. Kristián T. and Siesjö B. K. (1998) Calcium and ischemic cell death. Stroke 29, 705-718.
8. Lowry O. H., Rosebrough N. J., Farr A. L., and Randall R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
9. Meister A. (1995) Mitochondrial changes associated with glutathione deficiency. Biochim. Biophys. Acta 1271, 35-42.
10. Mignotte B. and Vayssiere J.-L. (1998) Mitochondria and apoptosis. Eur. J. Biochem. 252, 1-15.
11. Nicholls D. G. and Budd S. L. (1998) Mitochondria and neuronal glutamate. Biochim. Biophys. Acta 1366, 97-112.
12. Nieminen A. L., Petrie T. G., Lemasters J. J., and Selman W. R. (1996) Cyclosporin A delays mitochondrial depolarization induced by N-methyl-D-aspartate in cortical neurons: evidence of the mitochondrial permeability transition. Neuroscience 75, 993-997.
13. Pulsinelli W. A., Brierley J. B., and Plum F. (1982) Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann. Neurol. 11, 491-498.
14. Qin Z.-H., Wang Y., and Chase T. N. (1996) Stimulation of N-methyl-D-aspartate receptor induces apoptosis in rat brain. Brain Res. 725, 166-176.
15. Schinder A. F., Olson E. C., Spitzer N. C., and Montal M. (1996) Mitochondrial dysfunction is a primary event in glutamate neurotoxicity. J. Neurosci. 16, 5688-5697.
16. Shiga Y., Onodera H., Matsuo Y., and Kogure K. (1992) Cyclosporin A protects against ischemia-reperfusion injury in the brain. Brain Res. 595, 145-148.
17. Sims N. R. (1990) Rapid isolation of metabolically active mitochondria from rat brain and subregions using Percoll density gradient centrifugation. J. Neurochem. 55, 698-707.
18. Sims N. R. and Zaidan E. (1995) Biochemical changes associated with selective neuronal death following short-term cerebral ischaemia. Int. J. Biochem. Cell Biol. 27, 531-550.
19. Susin S. A., Zamzami N., and Kroemer G. (1998) Mitochondria as regulators of apoptosis: doubt no more. Biochim. Biophys. Acta 1366, 151-165.
20. Uchino H., Elmer E., Uchino K., and Lindvall O. (1995) Cyclosporin A dramatically ameliorates CA1 hippocampal damage following transient forebrain ischemia in the rat. Acta Physiol. Scand. 155, 469-471.
21. White R. J. and Reynolds I. J. (1996) Mitochondrial dysfunction in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure. J. Neurosci. 16, 5688-5697.
22. Zaidan E. and Sims N. R. (1994) The calcium content of mitochondria following short-term forebrain ischemia and recirculation in the rat. J. Neurochem. 63, 1812-1819.
23. Zaidan E. and Sims N. R. (1996) Alterations in the glutathione content of mitochondria following short-term forebrain ischemia in rats. Neurosci. Lett. 218, 75-78.
24. Zoratti M. and Szabo I. (1995) The mitochondrial permeability transition. Biochim. Biophys. Acta 1366, 151-165.