Structure and function of the BAH-containing domain of Orc1p in epigenetic silencing

EMBO Journal

Volumn 21, Issue 17, 2002, Pages 4600-4611

  Zhang, Zhiguo ^a   Hayashi, Mariko K ^a   Merkel, Olaf ^a   Stillman, Bruce ^a   Xu, Rui Ming ^a  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

Chromatin; Gene expression; Inheritance; Mating type; Origin recognition complex

Indexed keywords

BROMINE DERIVATIVE; CIS ACTING ELEMENT; PROTEIN; PROTEIN ORCP1; PROTEIN SIR3P; PROTEIN SIR4P; SILENT INFORMATION REGULATOR PROTEIN 2; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CHROMATIN; COMPLEX FORMATION; CRYSTAL STRUCTURE; GENE LOCUS; GENE MUTATION; GENE SILENCING; GENE STRUCTURE; GENETIC TRANSCRIPTION; HML GENE; HMR GENE; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; SILENT GENE; TELOMERE;

AMINO ACID SEQUENCE; BINDING SITES; CHROMATIN; CRYSTALLOGRAPHY, X-RAY; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENE SILENCING; HISTONE DEACETYLASES; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; ORIGIN RECOGNITION COMPLEX; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0037009519     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf468     Document Type: Article

References (41)

1. ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex
2. Yeast origin recognition complex functions in transcription silencing and DNA replication
3. The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing
4. The yeast HML I silencer defines a heterochromatin domain boundary by directional establishment of silencing
5. Connections between transcriptional activators, silencers, and telomeres as revealed by functional analysis of a yeast DNA-binding protein
6. The BAH (bromo-adjacent homology) domain: A link between DNA methylation, replication and transcriptional regulation
7. Acetylation of the yeast histone H4 N-terminus regulates its binding to heterochromatin protein SIR3
8. Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast
9. Roles for ORC in M phase and S phase
10. RNA polymerase III and RNA polymerase II promoter complexes are heterochromatin barriers in Saccharomyces cerevisiae
11. The boundaries of the silenced HMR domain in Saccharomyces cerevisiae
12. Deciphering NAD-dependent deacetylases
13. The role of Sas2, an acetyltransferase homologue of Saccharomyces cerevisiae, in silencing and ORC function
14. The origin recognition complex, SIR1, and the S phase requirement for silencing
15. The Sir1 protein's association with a silenced chromosome domain
16. A region of the Sir1 protein dedicated to recognition of a silencer and required for interaction with the Orc1 protein in Saccharomyces cerevisiae
17. The molecular biology of the SIR proteins
18. Yeast heterochromatin: Regulation of its assembly and inheritance by histones
19. Diverse and dynamic functions of the Sir silencing complex
20. Spreading of transcriptional repressor SIR3 from telomeric heterochromatin
21. Genetic evidence for an interaction between SIR3 and histone H4 in the repression of the silent mating loci in Saccharomyces cerevisiae
22. Genetic analysis of Rap1p/Sir3p interactions in telomeric and HML silencing in Saccharomyces cerevisiae
23. Silencers and domains of generalized repression
24. Silencing and heritable domains of gene expression
25. Silencing of genes at non-telomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap 1 protein
26. Nucleosome structure of the yeast CHA1 promoter: Analysis of activation-dependent chromatin remodeling of an RNA-polymerase-II-transcribed gene in TBP and RNA pol II mutants defective in vivo in response to acidic activators
27. Multiple interactions in Sir protein recruitment by Raplp at silencers and telomeres in yeast
28. Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes
29. Epigenetic inheritance of transcriptional states in S. cerevisiae
30. Yeast histone deposition protein Asf1p requires Hir proteins and PCNA for heterochromatic silencing
31. Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin
32. The Sir2 protein family: A novel deacetylase for gene silencing and more
33. Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements
34. Two classes of sir3 mutants enhance the sirl mutant mating defect and abolish telomeric silencing in Saccharomyces cerevisiae
35. SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast
36. Epigenetic switching of transcriptional states: cis- and trans-acting factors affecting establishment of silencing at the HMR locus in Saccharomyces cerevisiae
37. Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing
38. The RCAF complex mediates chromatin assembly during DNA replication and repair
39. De novo nucleosome assembly: New pieces in an old puzzle
40. PCNA connects DNA replication to epigenetic inheritance in yeast
41. Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase