When comparative information leads us astray: The receptor-binding region of colicin E9

Journal of Molecular Evolution

Volumn 55, Issue 3, 2002, Pages 347-355

  Dorit, Robert L ^a,b   Riley, Margaret A ^b  

^a SMITH COLLEGE   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

Antibiotic resistance; Antimicrobial; Bacteriocin; Co1E9; Colicin; Drug design; In vitro design; Protein engineering

Indexed keywords

BACTERIAL PROTEIN; COLICIN; COLICIN E9; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BTUB PROTEIN, E COLI; CARRIER PROTEIN; ESCHERICHIA COLI PROTEIN; OUTER MEMBRANE PROTEIN; RECEPTOR; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIMICROBIAL ACTIVITY; ARTICLE; CELL LINE; CONTROLLED STUDY; ESCHERICHIA COLI; GENE LOCATION; GENE MUTATION; GENETIC ENGINEERING; NONHUMAN; PHENOTYPE; PHYLOGENY; PROTEIN FUNCTION; PROTEIN INTERACTION; RECEPTOR BINDING; TARGET CELL; BINDING SITE; BIOLOGY; CELL DIVISION; COMPARATIVE STUDY; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN TERTIARY STRUCTURE;

ANTI-INFECTIVE AGENTS; BASE SEQUENCE; BINDING SITES; CELL DIVISION; COLICINS; COMPARATIVE STUDY; COMPUTATIONAL BIOLOGY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, PEPTIDE; RECOMBINANT PROTEINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; ANTI-BACTERIAL AGENTS; BACTERIAL OUTER MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0037008844     PISSN: 00222844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00239-002-2331-3     Document Type: Article

References (29)

1. Quantification of tertiary structural conservation despite primary sequence drift in the globin fold
2. Characterization of the Co1E9-J plasmid and analysis of its genetic organization
3. Investigation of the specificity of the interaction between colicin E9 and its immunity protein by site-directed mutagenesis
4. Complete nucleotide sequence of the colicin E9 (cei) gene
5. The relations of protein sequence and structural conservation with function
6. Phylogeny of the serpin superfamily: Implications of patterns of amino acid conservation for structure and function
7. Bacteriocins, microcins and lantibiotics
8. The biology of E colicins: Paradigms and paradoxes
9. Molecular evolution of E colicin plasmids with emphasis on the endonuclease types
10. Conservation among HSP60 sequences in relation to structure, function, and evolution
11. Structural conservation in prokaryotic and eukaryotic potassium channels
12. Effective use of sequence correlation and conservation in fold recognition
13. Origins and evolutionary diversification of the nuclear receptor superfamily
14. DNA Polymerase active site is highly mutable: Evolutionary consequences
15. A 76 residue polypeptide of colicin E9 confers receptor specificity and inhibits the growth of vitamin B12-dependent E. coli 113/3 cells
16. Methods for studying colicins and their plasmids
17. Modular multidomain phosphoryl transfer proteins of bacteria
18. Positive selection for colicin diversity in bacteria
19. Molecular mechanisms of colicin evolution
20. Molecular mechanisms of bacteriocin evolution
21. A survey of Col plasmids in natural isolates of Escherichia coli and an investigation into the stability of Col-plasmid lineages
22. Ecology and evolution of bacteriocins
23. The neighbor-joining method: A new method for reconstructing phylogenetic trees
24. Structure-based redesign of the catalytic/metal binding site of Cfr101 restriction endonuclease reveals importance of spatial rather than sequence conservation of active centre residues
25. Nucleotide polymorphism in colicin E2 gene clusters: Evidence for nonneutral evolution
26. Positive selection and recombination: Major molecular mechanisms in colicin diversification
27. Peptidyl transferase: Ancient and exiguous
28. Sterol 14-demethylase P450 (CYP51) provides a breakthrough for the discussion on the evolution of cytochrome P450 gene superfamily