Identification of cysteines involved in ligand binding to the human melatonin MT2 receptor

European Journal of Pharmacology

Volumn 449, Issue 1-2, 2002, Pages 29-38

  Mseeh, Faika ^a   Gerdin, Matthew J ^a   Dubocovich, Margarita L ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Cysteine; HEK 293 cell; Melatonin MT1 receptor, human; Melatonin MT2 receptor, human; Site directed mutagenesis; Thiol agents

Indexed keywords

2 IODOMELATONIN; ALANINE; CELL SURFACE RECEPTOR; CYSTEINE; DISULFIDE; DITHIOTHREITOL; GUANINE NUCLEOTIDE BINDING PROTEIN; MELATONIN RECEPTOR; N ETHYLMALEIMIDE; ALKYLATING AGENT; CELL RECEPTOR; COMPLEMENTARY DNA; DIAGNOSTIC AGENT; EPITOPE; FLAG PEPTIDE; LIGAND; MELATONIN; PEPTIDE; THIOL DERIVATIVE;

ALKYLATION; AMINO ACID SUBSTITUTION; ARTICLE; BINDING ASSAY; BINDING SITE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DISULFIDE BOND; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; RECEPTOR AFFINITY; RECEPTOR DENSITY; SITE DIRECTED MUTAGENESIS; CHEMISTRY; CONFOCAL MICROSCOPY; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM;

ALKYLATING AGENTS; CYSTEINE; DITHIOTHREITOL; DNA, COMPLEMENTARY; EPITOPES; ETHYLMALEIMIDE; HUMAN; IMMUNOHISTOCHEMISTRY; LIGANDS; MELATONIN; MICROSCOPY, CONFOCAL; MUTAGENESIS, SITE-DIRECTED; PEPTIDES; RECEPTORS, CELL SURFACE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SULFHYDRYL COMPOUNDS; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFECTION; HUMANS; RECEPTORS, MELATONIN;

EID: 0037008248     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)01903-9     Document Type: Article

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