A disulfide bond between conserved cysteines in the extracellular loops of the human VIP receptor is required for binding and activation

FEBS Letters

Volumn 412, Issue 1, 1997, Pages 141-143

  Knudsen, Sanne Møller ^a   Tams, Jeppe Wegener ^a   Wulff, Birgitte S ^b   Fahrenkrug, Jan ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

Author keywords

G protein coupled receptor; Site directed mutagenesis

Indexed keywords

ALANINE; CYCLIC AMP; CYSTEINE; DITHIOTHREITOL; IODINE 125; SERINE; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CELL LINE; CONTROLLED STUDY; DISULFIDE BOND; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS;

BINDING, COMPETITIVE; CELL LINE; CYCLIC AMP; CYSTEINE; DISULFIDES; DITHIOTHREITOL; HUMANS; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; VASOACTIVE INTESTINAL PEPTIDE;

EID: 0001552169     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(97)00714-X     Document Type: Article

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