Design of inhibitors of scytalone dehydratase: Probing interactions with an asparagine carboxamide

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 12, 2002, Pages 4143-4154

  Basarab, Gregory S ^a,b   Jordan, Douglas B ^a   Gehret, Troy C ^a   Schwartz, Rand S ^a  

^a DUPONT COMPANY   (United States)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,5 DICHLOROPHENOXY) 1 PHENYLPROP 2 YLAMINE; 1 (2,5 DIFLUOROPHENOXY) 1 PHENYLPROP 2 YLAMINE; 2 CYANO N [2 (2,5 DIFLUOROPHENOXY) 1 METHYL 2 PHENYLETHYL]BUTANAMIDE; 2 PYRROLIDINONE; 3 METHYL 2 PHENYLAZIRIDINYL BISMETHYLETHOXYPHOSPHIN 1 ONE; 6,9 DIOXA 3 THIASPIRO[4.4]NONANECARBOXYLIC ACID; ASPARAGINE CARBOXAMIDE; ASPARAGINE DERIVATIVE; HYDROLYASE; HYDROLYASE INHIBITOR; N [1 (4 BROMOPHENYL)ETHYL] 2 OXOCYCLOPENTYLCARBOXAMIDE; N [2 (2,5 DICHLOROPHENOXY) 1 METHYL 2 PHENYLETHYL] 2 OXOCYCLOHEXYLCARBOXAMIDE; N [2 (2,5 DICHLOROPHENOXY) 1 METHYL 2 PHENYLETHYL] 2 OXOCYCLOPENTYLCARBOXAMIDE; N [2 (2,5 DICHLOROPHENOXY) 1 METHYL 2 PHENYLETHYL] 2 OXOPYRROLIDIN 3 YLCARBOXAMIDE; N [2 (2,5 DICHLOROPHENOXY) 1 METHYL 2 PHENYLETHYL] 4 METHYL 2 OXOPYRROLIDIN 3 YLCARBOXAMIDE; N [2 (2,5 DICHLOROPHENOXY) 1 METHYL 2 PHENYLETHYL][2 OXO(3 PIPERIDYL)]CARBOXAMIDE; N [2 (2,5 DICHLOROPHENOXY) 1 METHYL 2 PHENYLETHYL][4 OXO(3,2,3,5 TRIHYDROTHIENYL)]CARBOXAMIDE; N [2 (2,5 DICHLOROPHENOXY)ISOPROPYL] 2 OXOCYCLOPENTYLCARBOXAMIDE; N [2 (2,5 DIFLUOROPHENOXY) 1 METHYL 2 PHENYLETHYL] 2 OXOCYCLOHEXYLCARBOXAMIDE; N [2 (2,5 DIFLUOROPHENOXY) 1 METHYL 2 PHENYLETHYL] 2 OXOCYCLOPENTYLCARBOXAMIDE; N [2 (2,5 DIFLUOROPHENOXY) 1 METHYL 2 PHENYLETHYL] 2 OXOPYRROLIDIN 3 YLCARBOXAMIDE; N [2 (2,5 DIFLUOROPHENOXY) 1 METHYL 2 PHENYLETHYL] 4 METHYL 2 OXOPYRROLIDIN 3 YLCARBOXAMIDE; N [2 (2,5 DIFLUOROPHENOXY) 1 METHYL 2 PHENYLETHYL][2 OXO(3 PIPERIDYL)]CARBOXAMIDE; N [2 (2,5 DIFLUOROPHENOXY) 1 METHYL 2 PHENYLETHYL][4 OXO(3,2,3,5 TRIHYDROTHIENYL)]CARBOXAMIDE; PHENYLALANINE; SCYTALONE DEHYDRATASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRICITY; FUNGICIDAL ACTIVITY; HYDROGEN BOND; NONHUMAN; WILD TYPE;

AMIDES; ASPARAGINE; BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; FUNGAL PROTEINS; FUNGICIDES, INDUSTRIAL; HYDRO-LYASES; HYDROGEN BONDING; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036978283     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00272-9     Document Type: Article

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