Design, synthesis, conformational analysis, and biological studies of urotensin-II lactam analogues

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 12, 2002, Pages 3731-3739

  Grieco, Paolo ^a   Carotenuto, Alfonso ^b   Patacchini, Riccardo ^c   Maggi, Carlo A ^c   Novellino, Ettore ^a   Rovero, Paolo ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

^c Menarini Ricerche SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DISULFIDE; HISTIDYLASPARTYL CYCLO(DIAMINOPROPIONIC ACID PHENYLALANYLTRYPTOPHYLLYSYLTYROSYLASPARTIC ACID)VALINE; HISTIDYLASPARTYL CYCLO(DIAMINOPROPIONIC ACID PHENYLALANYLTRYPTOPHYLLYSYLTYROSYLGLUTAMIC ACID)VALINE; HISTIDYLASPARTYL CYCLO(LYSYLPHENYLALANYLTRYPTOPHYLLYSYLTYROSYLASPARTIC ACID)VALINE; HISTIDYLASPARTYL CYCLO(LYSYLPHENYLALANYLTRYPTOPHYLLYSYLTYROSYLGLUTAMIC ACID)VALINE; HISTIDYLASPARTYL CYCLO(ORNITHYLPHENYLALANYLTRYPTOPHYLLYSYLTYROSYLASPARTIC ACID)VALINE; LACTAM DERIVATIVE; LYSINE; NEUROPEPTIDE; PHENYLALANINE; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; MOLECULAR MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION; THORACIC AORTA;

ANIMALS; AORTA; DRUG DESIGN; DRUG STABILITY; HUMANS; LACTAMS; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES, CYCLIC; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; UROTENSINS; VASOCONSTRICTOR AGENTS;

EID: 0036976236     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00372-3     Document Type: Article

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