Activation of peroxisome proliferator-activated receptor-γ inhibits apoptosis induced by serum deprivation in LLC-PK1 cells

Experimental Nephrology

Volumn 10, Issue 5-6, 2002, Pages 393-401

  Haraguchi, Kazutaka ^a   Shimura, Hiroki ^a   Onaya, Toshimasa ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Apoptosis; LLC PK1 cells; Peroxisome proliferator activated receptor ; Troglitazone

Indexed keywords

15 DEOXY GAMMA12,14 PROSTAGLANDIN J2; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ADENOSINE TRIPHOSPHATE; AGAROSE; CASPASE 3; DNA FRAGMENT; FAT; FATTY ACID; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PIRINIXIC ACID; PROSTAGLANDIN DERIVATIVE; ROSIGLITAZONE; TROGLITAZONE; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ASSAY; CELL CLONING; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; ELECTRON MICROSCOPY; ENZYME ACTIVATION; FLUORESCENCE MICROSCOPY; KIDNEY CELL; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SERUM;

ADENOSINE TRIPHOSPHATE; ANDROSTADIENES; ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELL SURVIVAL; CHROMANS; CULTURE MEDIA, SERUM-FREE; ENZYME INHIBITORS; LLC-PK1 CELLS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SWINE; THIAZOLES; THIAZOLIDINEDIONES; TRANSCRIPTION FACTORS;

EID: 0036972130     PISSN: 10187782     EISSN: None     Source Type: Journal    
DOI: 10.1159/000065303     Document Type: Article

References (39)

1. Tisher CC, Madsen KM: Anatomy of the kidney; in Brenner BM (ed): The Kidney. Philadelphia, Saunders, 1998, vol 1, pp 21-35.
2. Harrison DJ: Cell death in the diseased glomerulus. Histopathology 1988;12:679-683.
3. Lieberthal W, Koh JS, Levine JS: Necrosis and apoptosis in acute renal failure. Semin Nephrol 1998;18:505-518.
4. Fan S, Wang JA, Yuan RQ, Rockwell S, Andres S, Zlatapolskiy A, Goldberg ID, Rosen EM: Scatter factor protects epithelial and carcinoma cells against apoptosis induced by DNA-damaging agents. Oncogene 1998;17:131-141.
5. Thomas SE, Andoh TF, Pichler RH, Shankland SJ, Couser WG, Bennett WM, John RJ: Accelerated apoptosis characterizes cyclosporine-associated interstitial fibrosis. Kidney Int 1998;53:897-908.
6. Coles HS, Burne JF, Raff MC: Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor. Development 1993;118:777-784.
7. Tontonoz P, Hu E, Spiegelman B: Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor γ. Curr Opin Gene Dev 1995;5:571-576.
8. Buchanan TA, Meehan WP, Jeng YY, Yang D, Chan TM, Nadler JL, Scott S, Rude RK, Hsueh WA: Blood pressure lowering by pioglitazone. J Clin Invest 1995;96:354-360.
9. Tontonoz P, Laszio N, Alvarez JGA, Thomazy VA, Evans RM: PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 1998;93:241-252.
10. 2. J Biol Chem 1999;274:17042-17048.
11. Fulgencio JP, Kohl C, Girard J, Pegorier JP: Troglitazone inhibits fatty acid oxidation and esterification, and gluconeogenesis in isolated hepatocytes from starved rats. Diabetes 1996;45:1556-1562.
12. Guan Y, Zhang Y, Davis L, Breyer MD: Expression of peroxisome proliferator-activated receptors in urinary tract of rabbit and human. Am J Physiol 1997;273:F1013-F1022.
13. Imano E, Kanda T, Nakatani Y, Nishida T, Arai K, Motomura M, Kajimoto Y, Yamasaki Y, Hori M: Effect of troglitazone on microalbuminuria in patients with incipient diabetic nephropathy. Diabetes Care 1998;21:2135-2139.
14. Fujii M, Takemura R, Yamaguchi M, Hasegawa G, Shigeta H, Nakano K, Kondo M: Troglitazone (CS-045) ameliorates albuminuria in streptozotocin-induced diabetic rats. Metabolism 1997;46:981-983.
15. Isshiki K, Haneda M, Koya K, Maeda S, Kikkawa R: Troglitazone prevents the activation of protein kinase C and mitogen-activated protein kinase in diabetic glomeruli and mesangial cells cultured in high glucose. Diabetes 1998;47 (suppl):A51.
16. Ohta K, Endo T, Haraguchi K, Hershman JM, Onaya T: Ligands for peroxisome proliferator-activated receptor-γ inhibit growth and induces apoptosis of human papillary thyroid carcinoma cells. J Clin Endocrinol Metab 2001;86:2170-2177.
17. Haraguchi K, Shimura H, Ling Lin, Saito T, Endo T, Onaya T: Differentiation of rat preadipocytes is accompanied by expression of thyrotropin receptor. Endocrinology 1996;137:3200-3205.
18. Vankatachalam MA, Patel YJ, Kreisberg JI, Weinberg JM: Energy thresholds that determine membrane integrity and injury in a renal epithelial cell line (LLC-PK1). J Clin Invest 1988;81:745-758.
19. Nicolls DG: Bioenergetics: An Introduction to the Chemiosmotic Theory. London, Academic Press, 1982, pp 1-90.
20. Tilly JL, Hsueh AJW: Microscale autoradiographic method for the qualitative and quantitative analysis of apoptotic DNA fragmentation. J Cell Physiol 1993;154:519-526.
21. Haraguchi K, Shimura H, Kawaguchi A, Ikeda M, Endo T, Onaya T: Effects of thyrotropin on the proliferation and differentiation of cultured rat preadipocytes. Thyroid 1999;6:623-629.
22. Manniatis T, Fritch EF, Sambrook J: Extraction, purification and analysis of messenger RNA from eukaryotic cells; in Noran C (ed): Molecular Cloning; A Laboratory Manual. Cold Spring Harbor, Cold Spring Harbor Laboratory Press, 1982, vol 1, pp 187-210.
23. Shimabukuro M, Zhou YT, Levi M, Unger RH: Fatty-acid-induced β-cell apoptosis: A link between obesity and diabetes. Proc Natl Acad Sci USA 1998;95:2498-2502.
24. Lee WN, Lim S, Bassilian S, Bergner EA, Edmond J: Fatty acid cycling in human hepatoma cells and the effects of troglitazone. J Biol Chem 1998;273:20928-20934.
25. Hull RN, Cherry WR, Weaver GW: The origin and characteristics of a pig kidney cell strain LLK-PK1. In Vitro 1976;12:670-677.
26. Ma LJ, Marantoni C, Linton MR, Fazio S, Fogo AB: Peroxisome proliferator-activated receptor-γ agonist troglitazone protects against nondiabetic glomerulosclerosis in rats. Kidney Int 2001;59:1899-1910.
27. Guan YF, Breyen MD: Peroxisome proliferator-activated receptors (PPARs): Novel therapeutic targets in renal disease. Kidney Int 2001;60:14-30.
28. Zhang B, Berger J, Zou G, Elbrecht A, Subarna B, White-Carrington B, Szalkowski D, Moller ED: Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor γ. J Biol Chem 1996;271:31771-31774.
29. Franke TF, Kaplan DR, Cantley LC, Toker A: Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 1997;275:665-668.
30. Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME: Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 1997;275:661-665.
31. Franke TF, Kaplan DR, Cantley LC: PI3K: Downstream AKTion blocks apoptosis. Cell 1997;88:435-437.
32. Downward J: Signal transduction regulatory S6 kinase. Science 1994;371:378-379.
33. Peraldi P, Xu M, Spiegelman BM: Thiazolidinediones block tumor necrosis factor-α-induced inhibition of insulin signaling. J Clin Invest 1997;100:1863-1869.
34. Nobes CD, Reppas JB, Markus A, Tolkovsky AM: Active p21Ras is sufficient for rescue of NGF-dependent rat sympathetic neurons. Neuroscience 1996;70:1067-1069.
35. Tudan C, Jackson JK, Blanis L, Delech SL, Burt HM: Inhibition of TNFα-induced neutrophil apoptosis by crystals of calcium pyrophosphate dihydrate is mediated by the extracellular signal-regulated kinases and phosphatidylinositol-3-kinase/Akt pathways upstream of Caspase 3. J Immunol 2000;165:5798-5806.
36. Chou CC, Yung BY: Increased stability of nucleophosmin/B23 in antiapoptotic effect of ras during serum deprivation. Mol Pharmacol 2001;59:38-45.
37. Shichiri M, Yokokura M, Marumo F, Hirata Y: Endothelin-1 inhibits apoptosis of vascular smooth muscle cells induced by nitric oxide and serum deprivation via MAP kinase pathway. Arterioscler Thromb Vasc Biol 2000;20: 989-997.
38. Sparagna GC, Hickson-Bick DL: Cardiac fatty acid metabolism and the induction of apoptosis. Am J Med Sci 1999;318:15-21.
39. Chen Q, Galleano M, Cederman AI: Cytotoxicity and apoptosis produced by arachidonic acid in Hep G2 cells overexpressing human cytochrome P4502E1. J Biol Chem 1997;272:14532-14541.