The mevalonate pathway during acute tubular injury: Selected determinants and consequences

American Journal of Pathology

Volumn 161, Issue 2, 2002, Pages 681-692

  Zager, Richard A ^a,c   Shah, Vallabh O ^b   Shah, Hemangini V ^b   Zager, Philip G ^b   Johnson, Ali C M ^a   Hanson, Sherry ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MESSENGER RNA; MEVALONIC ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG;

ACUTE KIDNEY FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DISEASE PREDISPOSITION; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE DAMAGE; MALE; METABOLIC REGULATION; MOUSE; NONHUMAN; PRENYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0036966284     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64224-1     Document Type: Article

References (43)

1. Zager RA, Burkhart KM, Johnson A, Sacks B: Increased proximal tubular cholesterol content: implications for cell injury and the emergence of "acquired cytoresistance." Kidney Int 1999, 56:1788-1797
2. Zager RA, Kalhorn T: Changes in free and esterified cholesterol: hallmarks of acute tubular injury and acquired cytoresistance. Am J Pathol 2000, 157:1007-1016
3. Zager RA, Johnson A, Anderson K, Wright S: Cholesterol ester accumulation: an immediate consequence of acute ischemic renal injury. Kidney Int 2001, 59: 1750-1761
4. Zager RA, Andoh T, Bennett WM: Renal cholesterol accumulation: a durable response following acute and subacute renal insults. Am J Pathol 2001, 159:743-752
5. Zager RA, Johnson AC: Renal cortical cholesterol accumulation: an integral component of the systemic stress response. Kidney Int 2001, 60:2229-2310
6. Zager RA, Johnson A, Hanson S, dela Rosa V: Altered cholesterol localization and caveolin expression during the evolution of acute renal failure. Kidney Int (in press)
7. Zager RA: Plasma membrane cholesterol: a critical determinant of cellular energetics and tubular resistance to attack. Kidney Int 2000, 58:193-205
8. Zager RA: P glycoprotein-mediated cholesterol cycling: a potentially important determinant of proximal tubular cell viability. Kidney Int 2001, 60:944-956
9. Honda N, Hishida A, Ikuma K, Yonemura K: Acquired resistance to acute renal failure. Kidney Int 1987, 31:1233-1238
10. Nath KA, Haggard JJ, Croatt AJ, Grande JP, Poss KD, Alam J: The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo. Am J Pathol 2000, 156:1527-1535
11. Leung N, Croatt AJ, Haggard JJ, Grande JP, Nath KA: Acute cholestatic liver disease protects against glycerol-induced acute renal failure in the rat. Kidney Int 2001, 60:1047-1057
12. Nath KA, Balla G, Vercellotti GM, Balla J, Jacob HS, Levitt MD, Rosenberg ME: Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat. J Clin Invest 1992, 90:267-270
13. Zager RA, Baltes LA: Progressive renal insufficiency induces increasing protection against ischemic acute renal failure J Lab Clin Med 1984, 103:511-523
14. Zager RA, Baltes LA, Sharma HM, Jurkowitz MS: Responses of the ischemic acute renal failure kidney to additional ischemic events. Kidney Int 1984, 26:689-700
15. Goldstein JL, Brown MS: Regulation of the mevalonate pathway. Nature 1990, 343:425-430
16. Bjorkhem I, Lund E, Rudling M: Coordinate regulation of cholesterol, 7α hydroxylase, and HMG-CoA reductase in the liver. Subcellular Biochemistry, vol 28, Cholesterol: Its Functions and Metabolism in Biology and Medicine. Edited by R Bittman, New York, Plenum Press, 1997
17. Edwards PA, Tabor D, Kast HR, Venkateswaran A: Regulation of gene expression by SREBP and SCAP Biochim Biophys Acta 2000, 1529: 103-113
18. Thewke D, Kramer M, Sinensky MS: Transcriptional homeostatic control of membrane lipid composition Biochemical Biophys Res Commun 2000, 273:1-4
19. Shimano H: Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes. Prog Lipid Res 2001, 40:439-452
20. Sakai J, Rawson RB: The sterol regulatory element-binding protein pathway: control of lipid homeostasis through regulated intracellular transport. Curr Opin Lipidol 2001, 12:261-266
21. Nohturfft A, DeBose-Boyd RA, Scheek S, Goldstein JL, Brown MS: Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi. Proc Natl Acad Sci USA 1999, 96:11235-11240
22. Brown MS, Goldstein JL: A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc Natl Acad Sci USA 1999, 96:11041-11048
23. Edwards PA, Ericsson J: Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway. Annu Rev Biochem 1999, 68:157-185
24. Jackson SM, Ericsson J, Edwards PA: Signaling molecules derived from the cholesterol biosynthetic pathway. Subcellular Biochemistry, vol 28. Cholesterol: Its Functions and Metabolism in Biology and Medicine. Edited by R Bittman New York, Plenum Press, 1997
25. Xia Z, Tan MM, Wong WW, Dimitroulakos J, Minden MD, Penn LZ: Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells. Leukemia 2001, 15:1398-1407
26. McGuire TF, Sebti SM: Geranylgeraniol potentiates lovastatin inhibition of oncogenic H-Ras processing and signaling while preventing cytotoxicity. Oncogene 1997, 14:305-312
27. Limura O, Vrtovsnik F, Terzi F, Friedlander G: HMG-CoA reductase inhibitors induce apoptosis in mouse proximal tubular cells in primary culture. Kidney Int 1997; 52:962-972
28. Padayatty SJ, Marcelli M, Shao TC, Cunningham GR: Lovastatin-induced apoptosis in prostate stromal cells. J Clin Endocrinol Metab 1997, 82:1434-1439
29. Stark Jr WW, Blaskovich MA, Johnson BA, Qian Y, Vasudevan A, Pitt B, Hamilton AD, Sebto SM, Davies P: Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells. Am J Physiol 1998, 275:L55-L63.
30. Zager RA: Heme protein induced tubular cytoresistance: expression at the plasma membrane level. Kidney Int 1995, 47:1336-1345
31. Zager RA: Rhabdomyolysis and myohemoglobinuric acute renal failure. Kidney Int 1996, 49:314-326
32. Zager RA, Johnson AC, Hanson SY, Wasse M: Parenteral iron formulations: a comparative toxicologic analysis and mechanism of cell injury. Am J Kidney Dis 2002, 40:90-103
33. Ryan MJ, Johnson G, Kirk J, Fuerstenberg SM, Zager RA, Torok-Storb B: HK-2: an immortalized proximal tubule epithelial cell line from normal human kidney. Kidney Int 1994, 45:48-57
34. Iwata M, Herrington JB, Zager RA: Protein synthesis inhibition induces cytoresistance in cultured proximal tubular (HK-2) cells. Am J Physiol 1995, 268:F1154-F1163
35. Petras SF, Lindsey S, Harwood Jr HJ: HMG-CoA reductase regulation: use of structurally diverse first half-reaction squalene synthetase inhibitors to characterize the site of mevalonate-derived nonsterol regulator production in cultured IM-9 cells. J Lipid Res 1999, 40:24-38
36. Ravid T, Doolman R, Avner R, Harats D, Roitelman J: The ubiquitinproteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem 2000, 275:35840-35847
37. Bush KT, Goldberg AL, Nigam SK: Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance. J Biol Chem 1997, 272:9086-9092
38. Volloch V, Mosser DD, Massie B: Sherman MY: Reduced thermotolerance in aged cells results from a loss of an hsp72-mediated control of JNK signaling pathway. Cell Stress Chaperones 1998, 3:265-271
39. Utz PJ, Anderson P: Life and death decisions: regulation of apoptosis by proteolysis of signaling molecules. Cell Death Differ 2000, 7:589-602
40. Ou J, Tu H, Shan B, Luk A, DeBose-Boyd RA, Bashmakov Y, Goldstein JL, Brown MS: Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR. Proc Natl Acad Sci USA 2001, 98:6027-6032
41. Fantl WJ, Johnson DE, Williams LT: Signaling by receptor tyrosine kinases. Annu Rev Biochem 1993, 62:453-481
42. Deora AA, Win T, Vanhaesebroeck B, Lander HM: A redox triggered ras-effector interaction. Recruitment of phosphatidylinositil 3′-kinase to Ras by redox stress. J Biol Chem 1998, 273:29923-29928
43. Aikawa R, Komuro I, Yamazaki T, Zou Y, Kudoh S, Tanaka M, Shiojima I, Hiroi Y, Yazaki Y: Oxidative stress activates extracellular signal-regulated kinase through Src and Ras in cultured cells. J Clin Invest 1997, 100:1813-1821