L-arginyl-3,4-spermidine is neuroprotective in several in vitro models of neurodegeneration and in vivo ischaemia without suppressing synaptic transmission

British Journal of Pharmacology

Volumn 137, Issue 8, 2002, Pages 1255-1268

  Morrison III, Barclay ^a   Pringle, Ashley K ^a   McManus, Terence ^a   Ellard, John ^b   Bradley, Mark ^b   Signorelli, Francesco ^a   Iannotti, Fausto ^a   Sundstrom, Lars E ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Excitotoxicity; Free radical; Hippocampus; Ischaemia; Nitric oxide; Organotypic; Polyamine; Superoxide; Tissue culture

Indexed keywords

1 ARGINYL 3,4 SPERMIDINE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; POLYAMINE; SPERMIDINE DERIVATIVE; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN SLICE; COMBINATORIAL LIBRARY; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; ENZYME INHIBITION; EVOKED RESPONSE; FOREBRAIN; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; NERVE CELL LESION; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPTIC TRANSMISSION;

ANIMALS; ARGININE; CELL DEATH; CELL HYPOXIA; CELLS, CULTURED; HIPPOCAMPUS; ISCHEMIA; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR; SPERMIDINE; SYNAPTIC TRANSMISSION;

EID: 0036945109     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704986     Document Type: Article

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