How many pathways are available for nuclear protein import in cells

Acta Histochemica et Cytochemica

Volumn 35, Issue 6, 2002, Pages 435-440

  Yoneda, Yoshihiro ^a   Kametaka, Ai ^a   Sekimoto, Toshihiro ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Importin; Nuclear localization signal; Nuclear pore complex; Ran; Semi intact cells

Indexed keywords

CARRIER PROTEIN; CELL PROTEIN; CELL RECEPTOR; GUANOSINE TRIPHOSPHATASE; KARYOPHERIN; NUCLEAR PROTEIN; RAN PROTEIN; RNA; SMAD PROTEIN; STAT PROTEIN;

CELL COMMUNICATION; CELL NUCLEUS; CELL NUCLEUS MEMBRANE; CELL TRANSPORT; CYTOPLASM; EUKARYOTIC CELL; MACROMOLECULE; NUCLEAR LOCALIZATION SIGNAL; NUCLEAR PORE COMPLEX; NUCLEOCYTOPLASMIC TRANSPORT; PROTEIN FUNCTION; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION;

EUKARYOTA;

EID: 0036942821     PISSN: 00445991     EISSN: None     Source Type: Journal    
DOI: 10.1267/ahc.35.435     Document Type: Review

References (30)

1. Adam, S. A., Steme-Marr, R. and Gerace, L. (1991) In vitro nuclear protein import using permeabilized cells. Methods Cell Biol. 35; 469-482.
2. Conti, E., Uy, M., Leighton, L.,Blobel,G. and Kuriyan,J. (1998) Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha. Cell 94; 193-204.
3. Dingwall, C. and Laskey, R. A. (1991) Nuclear targeting sequences - a consensus? Trends Biochem. Sci. 16; 478-481.
4. Fagotto, F., Gluck, U. and Gumbiner, B. M. (1998) Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of β-catenin. Curr. Biol. 8; 181-190.
5. Floer, M., Blobel, G. and Rexach, M. (1997) Disassembly of RanGTP-karyopherin beta complex, an intermediate in nuclear protein import. J.. Biol. Chem. 272; 19538-19546.
6. Görlich, D., Henklein, P., Laskey, R. A. and Hartmann, E. (1996) A 41 amino acid motif in importin-α confers binding to importinβ and hence transit into the nucleus. EMBO J. 15; 1810-1817.
7. Görlich, D. and Mattaj, I. W. (1996) Nucleocytoplasmic transport. Science 271; 1513-1518.
8. Görlich, D., Pante, N., Kutay, U., Aebi, U. and Bischoff, F. R. (1996) Identification of different roles for RanGDP and RanGTP in nuclear protein import. EMBO J. 15; 5584-5594.
9. Görlich, D. and Kutay, U. (1999) Transport between the cell nucleus and cytoplasm. Annu. Rev. Cell Dev. Biol. 15; 607-660.
10. Imamoto, N., Shimamoto, T., Kose, S., Takao, T., Tachibana, T., Matsubae, M., Sekimoto, T., Shimonishi, Y. and Yoneda, Y. (1995) The nuclear pore-targeting complex binds to nuclear pores after association with a karyophile. FEBS Lett. 368; 415-419.
11. Imamoto, N., Shimamoto, T., Takao, T., Tachibana, T., Kose, S., Matsubae, M., Sekimoto, T., Shimonishi, Y. and Yoneda, Y. (1995) In vivo evidence for involvement of a 58 kDa component of nuclear pore-targeting complex in nuclear protein import. EMBO J. 14; 3617-3626.
12. Imamoto, N., Tachibana, T., Matsubae, M. and Yoneda, Y. (1995) A karyophilic protein forms a stable complex with cytoplasmic components prior to nuclear pore binding. J. Biol. Chem. 270;8559-8565.
13. Jakel, S. and Görlich, D. (1998) Importin β, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. EMBO J. 17; 4491-4502.
14. Kamei, Y., Yuba, S., Nakayama, T. and Yoneda, Y. (1999) Three distinct classes of the α-subunit of the nuclear pore-targeting complex (importin-α) are differentially expressed in adult mouse tissues. J. Histochem. Cytochem. 47; 363-372.
15. Kurisaki, A., Kose, S., Yoneda, Y., Heldin, C.-H. and Moustakas, A. (2001) Transforming growth factor-β induces nuclear import of Smad3 in an importin-β1 and Ran-dependent manner. Mol. Biol. Cell 12; 1079-1091.
16. Kutay, U., Bischoff, F. R., Kostka, S. Kraft, R. and Görlich, D. (1997) Export of importin a from the nucleus is mediated by a specific nuclear transport factor. Cell 90; 1061-1071.
17. Lounsbury, K. M. and Macara, I. G. (1997) Ran-binding protein 1 (RanBP1) forms a ternary complex with Ran and karyopherin beta and reduces Ran GTPase-activating protein (RanGAP) inhibition by karyopherin beta. J. Biol. Chem. 272; 551-555.
18. Miyamoto, Y., Imamoto, N., Sekimoto, T., Tachibana, T., Seki, T., Tada, S., Enomoto, T. and Yoneda, Y. (1997) Differential modes of nuclear localization signal (NLS) recognition by three distinct classes of NLS receptors. J. Biol. Chem. 272; 26375-26381.
19. Miyamoto, Y., Hieda, M., Harreman, M. T., Fukumoto, M., Saiwaki, T., Hodel, A. E., Corbett, A. H. and Yoneda, Y. (2002) Importin α can migrate into the nucleus in an importin β- and Ran-independent manner. EMBO J. 21; 5833-5842.
20. Nagoshi, E., Imamoto, N., Sato, R. and Yoneda, Y. (1999)Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin β with HLH-Zip. Mol. Biol. Cell 10; 2221-2233.
21. Nagoshi, E. and Yoneda, Y. (2001) Dimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin β. Mol. Cell. Biol. 21; 2779-2789.
22. Nemergut, M. E. and Macara, I. G. (2000) Nuclear import of the ran exchange factor, RCC1, is mediated by at least two distinct mechanism. J. Cell Biol. 149; 835-850.
23. Nigg, E. A. (1997) Nucleocytoplasmic transport: signals, mechanisms and regulation. Nature 386; 779-787.
24. Pollard, V. W., Michael, W. M., Nakielny, S., Siomi, M. C., Wang, F. and Dreyfuss, G. (1996) A novel receptor-mediated nuclear protein import pathway. Cell 86; 985-994.
25. Rexach, M. and Blobel, G. (1995) Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins. Cell 83; 683-692.
26. Sekimoto, T., Imamoto, N., Nakajima, K., Hirano, T. and Yoneda, Y. (1997) Extracellular signal-dependent nuclear import of Statl is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rchl. EMBO J. 16; 7067-7077.
27. Welch, K., Franke, J., Köhler, M. and Macara, I. G. (1999) RanBP3 contains an unusual nuclear localization signal that is imported preferentially by importin-α3. Mol. Cell. Biol. 19; 8400-8411.
28. Yano, R., Oakes, M. L., Tabb, M. M. and Nomura, M. (1994) Yeast Srplp has homology to armadillo/plakoglobin/β-catenin and participates in apparently multiple nuclear functions including the maintenance of the nucleolar structure. Proc. Natl. Acad. Sci. U S A 91; 6880-6884.
29. Yokoya, F., Imamoto, N., Tachibana, T. and Yoneda, Y. (1999) β-catenin can be transported into the nucleus in a Ran-unassisted manner. Mol. Biol. Cell 10; 1119-1131.
30. Yoneda, Y. (2000) Nucleocytoplasmic protein traffic and its significance to cell function. Genes Cells 5; 777-787.