Kuzbanian is required cell autonomously during notch signalling in the Drosophila wing

Development Genes and Evolution

Volumn 212, Issue 5, 2002, Pages 251-255

  Klein, Thomas ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Cell autonomy; Delta; Kuzbanian; Notch signalling; Wing development

Indexed keywords

LIGAND; METALLOPROTEINASE; NOTCH RECEPTOR;

ARTICLE; CONTROLLED STUDY; DROSOPHILA; FORELIMB; GENE ACTIVATION; GENE FUNCTION; HYPOTHESIS; LIMB DEVELOPMENT; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; SIGNAL TRANSDUCTION;

ANIMALS; DISINTEGRINS; DROSOPHILA; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; WING;

HEXAPODA;

EID: 0036935244     PISSN: 0949944X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00427-002-0233-4     Document Type: Article

References (17)

1. Brou C, Logeat F, Gupta N, Bessia C, LeBail O, Doedens JR, Cumano A, Roux P, Black RA, Israel A (2000) A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol Cell 5:207-216
2. Furriols M, Bray S (2001) A model response element detects Suppressor of Hairless-dependent molecular switch. Curr Biol 11:60-64
3. Klein T, Couso JP, Martinez-Arias A (1998) Wing development and specification of dorsal cell fates in the absence of apterous in Drosophila. Curr Biol 8:417-420
4. Li Y, Baker NE (2001) Proneural enhancement by Notch overcomes Suppressor-of-Hairless repressor function in the developing Drosophila eye. Curr Biol 11:330-338
5. Lieber T, Kidd S, Young M (2002) kuzbanian-mediated cleavage of Notch. Genes Dev 16:209-221
6. Logeat F, Bessia C, Brou C, Lebail O, Jarriault S, Seidah NG, Israel A (1998) The Notch 1 receptor is cleaved constitutively by a furin-like convertase. Proc Natl Acad Sci USA 95:8108-8112
7. Morel V, Schweisguth F (2000) Repression by Suppressor of Hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo. Genes Dev 14:377-388
8. Mumm JS, Kopan R (2000) Notch signaling: from the outside in. Dev Biol 228:151-165
9. Mumm JS, Schroeter EH, Saxena MS, Griesemer A, Tian X, Pan DJ, Ray WJ, Kopan R (2000) A ligand-induced extracellular cleavage regulates y-secretase-like proteolytic activation of Notch. Mol Cell 5:197-206
10. Pan D, Rubin GM (1997) Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell 90:271-280
11. Qi H, Rand MD, Wu X, Sestan N, Wang W, Rakic P, Xu T, Artavanis-Tsakonas S (1999) Processing of the notch ligand delta by the metalloprotease Kuzbanian. Science 283:91-94
12. Schroeter EH, Kisslinger JA, Kopan R (1998) Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 393:382-386
13. Shimizu K, Chiba S, Saito T, Takahashi T, Kumano K, Hamada Y, Hirai H (2002) Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain. EMBO J 21:294-302
14. Sotillos S, Roch F, Campuzano S (1997) The metalloprotease-disintegrin Kuzbanian participates in Notch activation and patterning of Drosophila imaginal discs. Development 124:4769-4779
15. Struhl G, Greenwald I (1999) Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature 398:522-525
16. Wen C, Metzstein MM, Greenwald I (1997) SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling. Development 124:4759-4767
17. Ye Y, Lukinova N, Fortini ME (1999) Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants. Nature 398:525-529