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Volumn 4, Issue 6, 1998, Pages 409-419

Increased sensitivity of the antiestrogen-resistant MCF-7/LY2 human breast carcinoma cell line to apoptosis induced by the novel microtubule stabilizing agent (+)-discodermolide

Author keywords

(+) discodermolide; Apoptosis; Flow cytometry; Paclitaxel; Pulsed field gel electrophoresis

Indexed keywords

ANTIESTROGEN; DISCODERMOLIDE; DNA FRAGMENT; ESTROGEN RECEPTOR; PACLITAXEL; STABILIZING AGENT; TAMOXIFEN;

EID: 0032417609     PISSN: 1075122X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1524-4741.1998.460409.x     Document Type: Article
Times cited : (9)

References (40)
  • 1
    • 0027968083 scopus 로고
    • Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer
    • Spencer CM, Faulds D. Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer. Drugs 1994;48:794-847.
    • (1994) Drugs , vol.48 , pp. 794-847
    • Spencer, C.M.1    Faulds, D.2
  • 2
    • 0029563137 scopus 로고
    • Docetaxel (Taxotere): An effective agent in the management of second-line breast cancer
    • van Oosterom AT. Docetaxel (Taxotere): an effective agent in the management of second-line breast cancer. Semin Oncol 1995;22:22-28.
    • (1995) Semin Oncol , vol.22 , pp. 22-28
    • Van Oosterom, A.T.1
  • 3
    • 0030272619 scopus 로고    scopus 로고
    • Computational and molecular modeling evaluation of the structural basis for tubulin polymerization inhibition by colchicine site agents
    • ter Haar E, Rosenkranz HS, Hamel E, Day BW. Computational and molecular modeling evaluation of the structural basis for tubulin polymerization inhibition by colchicine site agents. Bioorg Med Chem 1996;4:1659-71.
    • (1996) Bioorg Med Chem , vol.4 , pp. 1659-1671
    • Ter Haar, E.1    Rosenkranz, H.S.2    Hamel, E.3    Day, B.W.4
  • 4
    • 0029965342 scopus 로고    scopus 로고
    • Direct tubulin polymerization perturbation contributes significantly to the induction of micronuclei in vivo
    • ter Haar E, Day BW, Rosenkranz HS. Direct tubulin polymerization perturbation contributes significantly to the induction of micronuclei in vivo. Mutat Res 1996;350:331-37.
    • (1996) Mutat Res , vol.350 , pp. 331-337
    • Ter Haar, E.1    Day, B.W.2    Rosenkranz, H.S.3
  • 5
    • 0025160288 scopus 로고
    • Discodermolide - A new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta
    • Correction: J Org Chem 1991;56:1346
    • Gunasekera SP, Gunasekera M, Longley RE, Schulte GK. Discodermolide - a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta. J Org Chem 1990;55:4912-15. Correction: J Org Chem 1991;56:1346.
    • (1990) J Org Chem , vol.55 , pp. 4912-4915
    • Gunasekera, S.P.1    Gunasekera, M.2    Longley, R.E.3    Schulte, G.K.4
  • 6
    • 0030039669 scopus 로고    scopus 로고
    • Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol
    • ter Haar E, Kowalski RJ, Hamel E, et al. Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol. Biochemistry 1996;35:423-30.
    • (1996) Biochemistry , vol.35 , pp. 423-430
    • Ter Haar, E.1    Kowalski, R.J.2    Hamel, E.3
  • 7
    • 0030761586 scopus 로고    scopus 로고
    • The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol®) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells
    • Kowalski RJ, Giannakakou P, Gunasekera SP, Longley RE, Day BW, Hamel E. The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol®) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells. Mol Pharmacol 1997;52:613-22.
    • (1997) Mol Pharmacol , vol.52 , pp. 613-622
    • Kowalski, R.J.1    Giannakakou, P.2    Gunasekera, S.P.3    Longley, R.E.4    Day, B.W.5    Hamel, E.6
  • 8
    • 0031932291 scopus 로고    scopus 로고
    • The potent microtubule-stabilizing agent (+)-discodermolide induces apoptosis in human breast carcinoma cells -preliminary comparisons to paclitaxel
    • erratum: 369-70
    • Balachandran R, ter Haar E, Welsh MJ, Grant SG, Day BW. The potent microtubule-stabilizing agent (+)-discodermolide induces apoptosis in human breast carcinoma cells -preliminary comparisons to paclitaxel. Anticancer Drugs 1998;9:67-76 (erratum: 369-70).
    • (1998) Anticancer Drugs , vol.9 , pp. 67-76
    • Balachandran, R.1    Ter Haar, E.2    Welsh, M.J.3    Grant, S.G.4    Day, B.W.5
  • 10
    • 1842301715 scopus 로고    scopus 로고
    • Differential activity of Cremophor EL and paclitaxel in patients' tumor cells and human carcinoma cell lines in vitro
    • Csoka K, Dhar S, Fridborg H, Larsson R, Nygren P. Differential activity of Cremophor EL and paclitaxel in patients' tumor cells and human carcinoma cell lines in vitro. Cancer 1997;79:1225-33.
    • (1997) Cancer , vol.79 , pp. 1225-1233
    • Csoka, K.1    Dhar, S.2    Fridborg, H.3    Larsson, R.4    Nygren, P.5
  • 11
    • 0021927466 scopus 로고
    • Selection and characterization of a breast cancer cell line resistant to the antiestrogen LY 117018
    • Bronzert DA, Greene GL, Lippman ME. Selection and characterization of a breast cancer cell line resistant to the antiestrogen LY 117018. Endocrinology 1985;117:1409-17.
    • (1985) Endocrinology , vol.117 , pp. 1409-1417
    • Bronzert, D.A.1    Greene, G.L.2    Lippman, M.E.3
  • 12
    • 0029980263 scopus 로고    scopus 로고
    • Cytostatic and cytotoxic action of the antitumor agent Z-1,1-dichloro-2,3-diphenylcyclopropane in three human breast cancer cell lines
    • ter Haar E, Day BW. Cytostatic and cytotoxic action of the antitumor agent Z-1,1-dichloro-2,3-diphenylcyclopropane in three human breast cancer cell lines. Anticancer Res 1996; 16:1107-15.
    • (1996) Anticancer Res , vol.16 , pp. 1107-1115
    • Ter Haar, E.1    Day, B.W.2
  • 13
    • 0022641791 scopus 로고
    • Use of two MCF-7 cell variants to evaluate the growth regulatory potential of estrogen-induced products
    • Davidson NE, Bronzert DA, Chambon P, Gelmann EP, Lippman ME. Use of two MCF-7 cell variants to evaluate the growth regulatory potential of estrogen-induced products. Cancer Res 1986;46:1904-8.
    • (1986) Cancer Res , vol.46 , pp. 1904-1908
    • Davidson, N.E.1    Bronzert, D.A.2    Chambon, P.3    Gelmann, E.P.4    Lippman, M.E.5
  • 14
    • 0023879109 scopus 로고
    • Ligand-modulated regulation of progesterone receptor messenger ribonucleic acid and protein in human breast cancer cell lines
    • Read LD, Snider CE, Miller JS, Greene GL, Katzenel-lenbogen BS. Ligand-modulated regulation of progesterone receptor messenger ribonucleic acid and protein in human breast cancer cell lines. Mol Endocrinol 1988;2:263-71.
    • (1988) Mol Endocrinol , vol.2 , pp. 263-271
    • Read, L.D.1    Snider, C.E.2    Miller, J.S.3    Greene, G.L.4    Katzenel-lenbogen, B.S.5
  • 15
    • 0023856239 scopus 로고
    • Estrogens and growth factors induce the mRNA of the 52K-procathepsin-D secreted by breast cancer cells
    • Cavailles V, Augereau P, Garcia M, Rochefort H. Estrogens and growth factors induce the mRNA of the 52K-procathepsin-D secreted by breast cancer cells. Nucleic Acids Res 1988;16:1903-19.
    • (1988) Nucleic Acids Res , vol.16 , pp. 1903-1919
    • Cavailles, V.1    Augereau, P.2    Garcia, M.3    Rochefort, H.4
  • 16
    • 0025214532 scopus 로고
    • Compared effects of GnRH analogs and 4-hydroxytamoxifen on growth and steroid receptors in antiestrogen sensitive and resistant MCF-7 breast cancer cell sublines
    • Neri C, Berthois Y, Schatz B, Drieu K, Martin PM. Compared effects of GnRH analogs and 4-hydroxytamoxifen on growth and steroid receptors in antiestrogen sensitive and resistant MCF-7 breast cancer cell sublines. Breast Cancer Res Treat 1990;15:85-93.
    • (1990) Breast Cancer Res Treat , vol.15 , pp. 85-93
    • Neri, C.1    Berthois, Y.2    Schatz, B.3    Drieu, K.4    Martin, P.M.5
  • 17
    • 0025191263 scopus 로고
    • Characterization of the estrogen receptor in two antiestrogen-resistant cell lines, LY2 and T47D
    • Mullick A, Chambon P. Characterization of the estrogen receptor in two antiestrogen-resistant cell lines, LY2 and T47D. Cancer Res 1990;50:333-38.
    • (1990) Cancer Res , vol.50 , pp. 333-338
    • Mullick, A.1    Chambon, P.2
  • 19
    • 0026775668 scopus 로고
    • Tamoxifen-resistant human breast cancer cell growth: Inhibition by thioridazine, pimozide and the calmodulin antagonist, W-13
    • Strobl JS, Peterson VA. Tamoxifen-resistant human breast cancer cell growth: inhibition by thioridazine, pimozide and the calmodulin antagonist, W-13. J Pharmacol Exp Therapeut 1992;263:186-93.
    • (1992) J Pharmacol Exp Therapeut , vol.263 , pp. 186-193
    • Strobl, J.S.1    Peterson, V.A.2
  • 20
    • 0028365131 scopus 로고
    • A survey of human breast cancer sensitivity to growth inhibition by calmodulin antagonists in tissue culture
    • Strobl JS, Peterson VA, Woodfork KA. A survey of human breast cancer sensitivity to growth inhibition by calmodulin antagonists in tissue culture. Biochem Pharmacol 1994;47: 2157-61.
    • (1994) Biochem Pharmacol , vol.47 , pp. 2157-2161
    • Strobl, J.S.1    Peterson, V.A.2    Woodfork, K.A.3
  • 22
    • 0030067040 scopus 로고    scopus 로고
    • Changes in insulin-like growth factor-I receptor expression and binding protein secretion associated with tamoxifen resistance and estrogen independence in human breast cancer cells in vitro
    • McCotter D, van den Berg HW, Boylan M, McKibben B. Changes in insulin-like growth factor-I receptor expression and binding protein secretion associated with tamoxifen resistance and estrogen independence in human breast cancer cells in vitro. Cancer Lett 1996;99:239-45.
    • (1996) Cancer Lett , vol.99 , pp. 239-245
    • McCotter, D.1    Van Den Berg, H.W.2    Boylan, M.3    McKibben, B.4
  • 23
    • 0026073718 scopus 로고
    • Mouse micronucleus tests with known and suspect spindle poisons: Results from two laboratories
    • Adler ID, Kliesch U, van Hummelen P, Kirsch-Volders M. Mouse micronucleus tests with known and suspect spindle poisons: results from two laboratories. Mutagenesis 1991;6:47-53.
    • (1991) Mutagenesis , vol.6 , pp. 47-53
    • Adler, I.D.1    Kliesch, U.2    Van Hummelen, P.3    Kirsch-Volders, M.4
  • 24
    • 0027972061 scopus 로고
    • Differential induction of etoposide-mediated apoptosis in human leukemia HL-60 and K562 cells
    • Ritke MK, Rusnak JM, Lazo JS, et al. Differential induction of etoposide-mediated apoptosis in human leukemia HL-60 and K562 cells. Mol Pharmacol 1994;46:605-11.
    • (1994) Mol Pharmacol , vol.46 , pp. 605-611
    • Ritke, M.K.1    Rusnak, J.M.2    Lazo, J.S.3
  • 25
    • 0026492817 scopus 로고
    • Features of apoptotic cells applicable for gel electrophoresis and flow cytometry
    • Darzynkiewicz Z, Bruno S, Del Bino G, et al. Features of apoptotic cells applicable for gel electrophoresis and flow cytometry. Cytometry 1992;13:795-808.
    • (1992) Cytometry , vol.13 , pp. 795-808
    • Darzynkiewicz, Z.1    Bruno, S.2    Del Bino, G.3
  • 27
    • 0028505014 scopus 로고
    • Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides
    • Hung DT, Nerenberg JB, Schreiber SL. Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides. Chem Biol 1994;1:67-71.
    • (1994) Chem Biol , vol.1 , pp. 67-71
    • Hung, D.T.1    Nerenberg, J.B.2    Schreiber, S.L.3
  • 28
    • 0030020158 scopus 로고    scopus 로고
    • Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death
    • Jordan MA, Wendell K, Gardiner S, Derry WB, Copp H, Wilson L. Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death. Cancer Res 1996;56:816-25.
    • (1996) Cancer Res , vol.56 , pp. 816-825
    • Jordan, M.A.1    Wendell, K.2    Gardiner, S.3    Derry, W.B.4    Copp, H.5    Wilson, L.6
  • 29
    • 0027217084 scopus 로고
    • Apoptotic cell death in epithelial cells: Cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation
    • Oberhammer F, Wilson JW, Dive C, et al. Apoptotic cell death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J 1993;12:3679-84.
    • (1993) EMBO J , vol.12 , pp. 3679-3684
    • Oberhammer, F.1    Wilson, J.W.2    Dive, C.3
  • 31
    • 0030846513 scopus 로고    scopus 로고
    • Cellular targets of the anti-breast cancer agent Z-1,1-dichloro-2,3-diphenylcyclopropane: Type II estrogen binding sites and tubulin
    • ter Haar E, Hamel E, Balachandran R, Day BW. Cellular targets of the anti-breast cancer agent Z-1,1-dichloro-2,3-diphenylcyclopropane: type II estrogen binding sites and tubulin. Anticancer Res 1997;17:1861-69.
    • (1997) Anticancer Res , vol.17 , pp. 1861-1869
    • Ter Haar, E.1    Hamel, E.2    Balachandran, R.3    Day, B.W.4
  • 32
    • 0027858856 scopus 로고
    • Total synthesis of the immunosuppressive agent (-)-discodermolide
    • Nerenberg JB, Hung DT, Somers PK, Schreiber SL. Total synthesis of the immunosuppressive agent (-)-discodermolide. J Am Chem Soc 1993;115:12621-22.
    • (1993) J Am Chem Soc , vol.115 , pp. 12621-12622
    • Nerenberg, J.B.1    Hung, D.T.2    Somers, P.K.3    Schreiber, S.L.4
  • 34
    • 0029860912 scopus 로고    scopus 로고
    • Synthesis of discodermolides useful for investigating microtubule binding and stabilization
    • Hung DT, Nerenberg JB, Schreiber SL. Synthesis of discodermolides useful for investigating microtubule binding and stabilization. J Am Chem Soc 1996;118:11054-80.
    • (1996) J Am Chem Soc , vol.118 , pp. 11054-11080
    • Hung, D.T.1    Nerenberg, J.B.2    Schreiber, S.L.3
  • 35
    • 0028070358 scopus 로고
    • 1 phase by interference with spindle formation without affecting other microtubule functions during anaphase and telophase
    • 1 phase by interference with spindle formation without affecting other microtubule functions during anaphase and telophase. Cancer Res 1994;54:4355-61.
    • (1994) Cancer Res , vol.54 , pp. 4355-4361
    • Long, B.H.1    Fairchild, C.R.2
  • 36
    • 0030113284 scopus 로고    scopus 로고
    • (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest
    • Hung DT, Chen J, Schreiber SL. (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest. Chem Biol 1996;3:287-93.
    • (1996) Chem Biol , vol.3 , pp. 287-293
    • Hung, D.T.1    Chen, J.2    Schreiber, S.L.3
  • 37
    • 0028793720 scopus 로고
    • Enhanced interaction between tubulin and microtubule-associated protein 2 via inhibition of MAP kinase and cdc2 kinase by paclitaxel
    • Nishio K, Arioka H, Ishida T, et al. Enhanced interaction between tubulin and microtubule-associated protein 2 via inhibition of MAP kinase and cdc2 kinase by paclitaxel. Int J Cancer 1995;63:688-93.
    • (1995) Int J Cancer , vol.63 , pp. 688-693
    • Nishio, K.1    Arioka, H.2    Ishida, T.3
  • 38
    • 0029964257 scopus 로고    scopus 로고
    • Taxol induces bcl-2 phosphorylation and death of prostate cancer cells
    • Haldar S, Chintapalli J, Croce CM. Taxol induces bcl-2 phosphorylation and death of prostate cancer cells. Cancer Res 1996;56:1253-55.
    • (1996) Cancer Res , vol.56 , pp. 1253-1255
    • Haldar, S.1    Chintapalli, J.2    Croce, C.M.3
  • 39
    • 0031035693 scopus 로고    scopus 로고
    • Bcl2 is the guardian of microtubule integrity
    • Haldar S, Basu A, Croce CM. Bcl2 is the guardian of microtubule integrity. Cancer Res 1997;57:229-33.
    • (1997) Cancer Res , vol.57 , pp. 229-233
    • Haldar, S.1    Basu, A.2    Croce, C.M.3
  • 40
    • 0029913172 scopus 로고    scopus 로고
    • Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway
    • Blagosklonny MV, Schulte T, Nguyen P, Trepel J, Neckers LM. Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway. Cancer Res 1996;56:1851-54.
    • (1996) Cancer Res , vol.56 , pp. 1851-1854
    • Blagosklonny, M.V.1    Schulte, T.2    Nguyen, P.3    Trepel, J.4    Neckers, L.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.