Evolutionary conserved sequences are required for the insulation of the vertebrate Hoxd complex in neural cells

Development

Volumn 129, Issue 23, 2002, Pages 5521-5528

  Kmita, Marie ^a   Tarchini, Basile ^a   Duboule, Denis ^a   Hérault, Yann ^b  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b CNRS   (France)

Author keywords

Gene regulation; Hox complex; Insulator; Mouse

Indexed keywords

CIS ACTING ELEMENT; CONTIG; DNA FRAGMENT; HOX PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; EMBRYO DEVELOPMENT; ENHANCER REGION; GENE ACTIVATION; GENE ACTIVITY; GENE CLUSTER; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENE STRUCTURE; GENETIC CONSERVATION; HOX GENE; MOLECULAR EVOLUTION; MOUSE; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PREVENTION; PRIORITY JOURNAL; REGULATORY SEQUENCE; TRANSCRIPTION REGULATION; VERTEBRATE;

ANIMALS; BASE SEQUENCE; CONSERVED SEQUENCE; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE TARGETING; GENES, REGULATOR; HOMEODOMAIN PROTEINS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; NEURONS; PROMOTER REGIONS (GENETICS); REGULATORY SEQUENCES, NUCLEIC ACID; TRANSCRIPTION, GENETIC;

ANIMALIA; VERTEBRATA;

EID: 0036924992     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.00151     Document Type: Article

References (48)

1. Barges, S., Mihaly, J., Galloni, M., Hagstrom, K., Muller, M., Shanower, G., Schedl, P., Gyurkovics, H. and Karch, F. (2000). The Fab-8 boundary defines the distal limit of the bithorax complex iab- 7 domain and insulates iab-7 from initiation elements and a PRE in the adjacent iab-8 domain. Development 127, 779-790.
2. Bastian, H., Gruss, P., Duboule, D. and Izpisua-Belmonte, J. C. (1992). The murine even-skipped-like gene Evx-2 is closely linked to the Hox-4 complex, but is transcribed in the opposite direction. Mamm. Genome 3, 241-243.
3. Beckers, J. and Duboule, D. (1998). Genetic analysis of a conserved sequence in the HoxD complex: regulatory redundancy or limitations of the transgenic approach? Dev. Dyn. 213, 1-11.
4. Bell, A. C., West, A. G. and Felsenfeld, G. (1999). The protein CTCF is required for the enhancer blocking activity of vertebrate insulators. Cell 98, 387-396.
5. Bell, A. C., West, A. G. and Felsenfeld, G. (2001). Insulators and boundaries: versatile regulatory elements in the eukaryotic genome. Science 291, 447-450.
6. Boulet, A. M., Lloyd, A. and Sakonju, S. (1991). Molecular definition of the morphogenetic and regulatory functions and the cis-regulatory elements of the Drosophila Abd-B homeotic gene. Development 111, 393-405.
7. Brulfert, A., Monnot, M. J. and Geraudie, J. (1998). Expression of two even-skipped genes eve1 and evx2 during zebrafish fin morphogenesis and their regulation by retinoic acid. Int. J. Dev. Biol. 42, 1117-1124.
8. Bulger, M., van Doorninck, J. H., Saitoh, N., Telling, A., Farrell, C., Bender, M. A., Felsenfeld, G., Axel, R., Groudine, M. and von Doorninck, J. H. (1999). Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. Proc. Natl. Acad. Sci. USA 96, 5129-5134.
9. Celniker, S. E., Sharma, S., Keelan, D. J. and Lewis, E. B. (1990). The molecular genetics of the bithorax complex of Drosophila: cis- regulation in the Abdominal-B domain. EMBO J. 9, 4277-4286.
10. Deschamps, J., van den Akker, E., Forlani, S., de Graaff, W., Oosterveen, T., Roelen, B. and Roelfsema, J. (1999). Initiation, establishment and maintenance of Hox gene expression patterns in the mouse. Int. J. Dev. Biol. 43, 635-650.
11. D'Esposito, M., Morelli, F., Acampora, D., Migliaccio, E., Simeone, A. and Boncinelli, E. (1991). EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5′ end of HOX4 locus on chromosome 2. Genomics 10, 43-50.
12. Dollé, P., Fraulob, V. and Duboule, D. (1994). Developmental expression of the mouse Evx-2 gene: relationship with the evolution of the HOM/Hox complex. Development Suppl., 143-153.
13. Duboule, D. (1998). Vertebrate hox gene regulation: clustering and/or colinearity? Curr. Opin. Genet. Dev. 8, 514-518.
14. Dupe, V., Davenne, M., Brocard, J., Dollé, P., Mark, M., Dierich, A., Chambon, P. and Rijli, F. M. (1997). In vivo functional analysis of the Hoxa-13′ retinoic acid response element (3′RARE). Development 124, 399-410.
15. Gerard, M., Chen, J. Y., Gronemeyer, H., Chambon, P., Duboule, D. and Zakany, J. (1996). In vivo targeted mutagenesis of a regulatory element required for positioning the Hoxd-11 and Hoxd-10 expression boundaries. Genes Dev. 10, 2326-2334.
16. Hérault, Y., Hraba-Renevey, S., van der Hoeven, F. and Duboule, D. (1996). Function of the Evx-2 gene in the morphogenesis of vertebrate limbs. EMBO J. 15, 6727-6738.
17. Hérault, Y., Beckers, J., Kondo, T., Fraudeau, N. and Duboule, D. (1998a). Genetic analysis of a Hoxd-12 regulatory element reveals global versus local modes of controls in the HoxD complex. Development 125, 1669-1677.
18. Hérault, Y., Rassoulzadegan, M., Cuzin, F. and Duboule, D. (1998b). Engineering chromosomes in mice through targeted meiotic recombination (TAMERE). Nat. Genet. 20, 381-384.
19. Kmita, M., Kondo, T. and Duboule, D. (2000a). Targeted inversion of a polar silencer within the HoxD complex re- allocates domains of enhancer sharing. Nat.. Genet. 26, 451-454.
20. Kmita, M., van der Hoeven, F., Zakany, J., Krumlauf, R. and Duboule, D. (2000b). Mechanisms of Hox gene colinearity: transposition of the anterior Hoxb1 gene into the posterior HoxD complex. Genes Dev. 14, 198-211.
21. Kmita, M., Fraudeau, N., Hérault, Y. and Duboule, D. (2002). Serial locus deletions and duplications in vivo suggests a mechanism for Hoxd genes colinearity in the making of digits. Nature (in press).
22. Knezevic, V., de Santo, R., Schughart, K., Huffstadt, U., Chiang, C., Mahon, K. A. and Mackem, S. (1997). Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop. Development 124, 4523-4536.
23. Kondo, T. and Duboule, D. (1999). Breaking colinearity in the mouse HoxD complex. Cell 97, 407-417.
24. Kondo, T., Zakany, J. and Duboule, D. (1998). Control of colinearity in AbdB genes of the mouse HoxD complex. Mol. Cell 1, 289-300.
25. Krumlauf, R. (1994). Hox genes in vertebrate development. Cell 78, 191-201.
26. McLain, K., Schreiner, C., Yager, K. L., Stock, J. L. and Potter, S. S. (1992). Ectopic expression of Hox-2.3 induces craniofacial and skeletal malformations in transgenic mice. Mech. Dev. 39, 3-16.
27. Mihaly, J., Hogga, I., Gausz, J., Gyurkovics, H. and Karch, F. (1997). In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response element. Development 124, 1809-1820.
28. Moran-Rivard, L., Kagawa, T., Saueressig, H., Gross, M. K., Burrill, J. and Goulding, M. (2001). Evx1 is a postmitotic determinant of v0 interneuron identity in the spinal cord. Neuron 29, 385-399.
29. Morgan, B. A., Izpisua-Belmonte, J. C., Duboule, D. and Tabin, C. J. (1992). Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations. Nature 358, 236-239.
30. Ohtsuki, S. and Levine, M. (1998). GAGA mediates the enhancer blocking activity of the eve promoter in the Drosophila embryo. Genes Dev. 12, 3325-3330.
31. Prioleau, M. N., Nony, P., Simpson, M. and Felsenfeld, G. (1999). An insulator element and condensed chromatin region separate the chicken beta-globin locus from an independently regulated erythroid-specific folate receptor gene. EMBO J. 18, 4035-4048.
32. Renucci, A., Zappavigna, V., Zakany, J., Izpisua-Belmonte, J. C., Burki, K. and Duboule, D. (1992). Comparison of mouse and human HOX-4 complexes defines conserved sequences involved in the regulation of Hox-4.4. EMBO J. 11, 1459-1468.
33. Rijli, F. M., Dollé, P., Fraulob, V., LeMeur, M. and Chambon, P. (1994). Insertion of a targeting construct in a Hoxd-10 allele can influence the control of Hoxd-9 expression. Dev. Dyn. 201, 366-377.
34. Saitoh, N., Bell, A. C., Recillas-Targa, F., West, A. G., Simpson, M., Pikaart, M. and Felsenfeld, G. (2000). Structural and functional conservation at the boundaries of the chicken beta-globin domain. EMBO J. 19, 2315-2322.
35. Sanchez-Herrero, E. (1991). Control of the expression of the bithorax complex genes abdominal-A and abdominal-B by cis-regulatory regions in Drosophila embryos. Development 111, 437-449.
36. Sharpe, J., Nonchev, S., Gould, A., Whiting, J. and Krumlauf, R. (1998). Selectivity, sharing and competitive interactions in the regulation of Hoxb genes. EMBO J. 17, 1788-1798.
37. Sordino, P., Duboule, D. and Kondo, T. (1996). Zebrafish Hoxa and Evx-2 genes: cloning, developmental expression and implications for the functional evolution of posterior Hox genes. Mech Dev. 59, 165-175.
38. Spitz, F., Gonzalez, F., Peichel, C., Vogt, T. F., Duboule, D. and Zakany, J. (2001). Large scale transgenic and cluster deletion analysis of the HoxD complex separate an ancestral regulatory module from evolutionary innovations. Genes Dev. 15, 2209-2214.
39. Sun, F. L. and Elgin, S. C. (1999). Putting boundaries on silence. Cell 99, 459-462.
40. Udvardy, A. (1999). Dividing the empire: boundary chromatin elements delimit the territory of enhancers. EMBO J. 18, 1-8.
41. van der Hoeven, F., Zakany, J. and Duboule, D. (1996). Gene transpositions in the HoxD complex reveal a hierarchy of regulatory controls. Cell 85, 1025-1035.
42. Vidal, F., Sage, J., Cuzin, F. and Rassoulzadegan, M. (1998). Cre expression in primary spermatocytes: a tool for genetic engineering of the germ line. Mol. Reprod. Dev. 51, 274-280.
43. Yokouchi, Y., Nakazato, S., Yamamoto, M., Goto, Y., Kameda, T., Iba, H. and Kuroiwa, A. (1995). Misexpression of Hoxa-13 induces cartilage homeotic transformation and changes cell adhesiveness in chick limb buds. Genes Dev. 9, 2509-2522.
44. Zakany, J. and Duboule, D. (1999). Hox genes and the making of sphincters. Nature 401, 761-762.
45. Zakany, J., Fromental-Ramain, C., Warot, X. and Duboule, D. (1997a). Regulation of number and size of digits by posterior Hox genes: a dose-dependent mechanism with potential evolutionary implications. Proc. Natl. Acad. Sci. USA 94, 13695-13700.
46. Zakany, J., Gerard, M., Favier, B. and Duboule, D. (1997b). Deletion of a HoxD enhancer induces transcriptional heterochrony leading to transposition of the sacrum. EMBO J. 16, 4393-4402.
47. Zhou, J. and Levine, M. (1999). A novel cis-regulatory element, the PTS, mediates an anti-insulator activity in the Drosophila embryo. Cell 99, 567-575.
48. Zhou, J., Ashe, H., Burks, C. and Levine, M. (1999). Characterization of the transvection mediating region of the abdominal- B locus in Drosophila. Development 126, 3057-3065.