GAGA mediates the enhancer blocking activity of the eve promoter in the Drosophila embryo

Genes and Development

Volumn 12, Issue 21, 1998, Pages 3325-3330

  Ohtsuki, Sumio ^a,b   Levine, Michael ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Human Frontiers Science Program

Author keywords

Drosophila embryo; Enhancer promoter interactions; GAGA; Insulators

Indexed keywords

ANIMAL CELL; ARTICLE; CELL INTERACTION; CHIMERA; DROSOPHILA; EMBRYO DEVELOPMENT; ENHANCER REGION; GENE CLUSTER; GENE LOCATION; GENE LOCUS; GENETIC REGULATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA INTERACTION; RETROPOSON;

ANIMALIA; DROSOPHILA; HEXAPODA;

EID: 0032213217     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.21.3325     Document Type: Article

References (37)

1. Arkhipova, I.R. 1995. Promoter elements in Drosophila melanogaster revealed by sequence analysis. Genetics 139: 1359-1369.
2. Bhat, K.M., G. Farkas, F. Karch, H. Gyurkovics, J. Gausz, and P. Schedl. 1996. The GAGA factor is required in the early Drosophila embryo not only for transcriptional regulation but also for nuclear division. Development 122: 1113-1124.
3. Burke, T.W. and J.T. Kadonaga. 1996. Drosophila TFIID binds to a conserved downsteam basal promoter element that is present in many TAT-box-deficient promoters. Genes & Dev. 10: 711-724.
4. _. 1997. The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila. Genes & Dev. 11: 3020-3031.
5. Cai, H. and M. Levine. 1995. Modulation of enhancer-promoter interactions by insulators in the Drosophila embryo. Nature 376: 533-536.
6. Choi, O.R. and J.D. Engel. 1988. Developmental regulation of beta-globin gene switching. Cell 55: 17-26.
7. Dorsett, D. 1993. Distance-independent inactivation of an enhancer by the suppressor of Hairy-wing DNA-binding protein of Drosophila. Genetics 134: 1135-1144.
8. Farkas, G., J. Gausz, M. Galloni, G. Reuter, H. Gyurkovics, and F. Karch. 1994. The Trithorax-like gene encodes the Drosophila GAGA factor. Nature 371: 806-808.
9. Foley, K.P. and J.D. Engel. 1992. Individual stage selector element mutations lead to reciprocal changes in β vs. ∈-globin gene transcription: Genetic confirmation of promoter competition during globin gene switching. Genes & Dev. 6: 730-744.
10. Gerasimova, T.I. and V.G. Corces. 1998. Polycomb and trithorax group proteins mediate the function of a chromatin insulator. Cell 92: 511-521.
11. Gerasimova, T.I., D.A. Gdula, D.V. Gerasimov, O. Simonova, and V.G. Corces. 1995. A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation. Cell 82: 587-597.
12. Geyer, P.K. 1997. The role of insulator elements in defining domains of gene expression. Curr. Opin. Genet. Dev. 7: 242-248.
13. Geyer, P.K. and V.G. Corces. 1992. DNA position-specific repression of transcription by a Drosophila zinc finger protein. Genes & Dev. 6: 1865-1873.
14. Gorman, M.J. and T.C. Kaufman. 1995. Genetic analysis of embryonic cis-acting regulatory elements of the Drosophila homeotic gene sex combs reduced. Genetics 140: 557-572.
15. Hagstrom, K., M. Muller, and P. Schedl. 1996. Fab-7 functions as a chromatin domain boundary to ensure proper segment specification by the Drosophila bithorax complex. Genes & Dev. 10: 3202-3215.
16. Henikoff, S. 1996. Dosage-dependent modification of position-effect variegation in Drosophila. BioEssays 18: 401-409.
17. Herault, Y., N. Fraudeau, J. Zakany, and D. Duboule. 1997. Ulnaless (Ul), a regulatory mutation inducing both loss-of-function and gain-of-function of posterior Hoxd genes. Development 124: 3493-3500.
18. Jiang, J., D. Kosman, Y.T. Ip, and M. Levine. 1991. The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos. Genes & Dev. 5: 1881-1891.
19. Kellum, R. and P. Schedl. 1991. A position-effect assay for boundaries of higher order chromosomal domains. Cell 72: 741-752.
20. _. 1992. A group of ses elements function as domain boundaries in an enhancer-blocking assay. Mol. Cell. Biol. 12: 2424-2431.
21. Laughon, A. and M.P. Scott. 1984. Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins. Nature 310: 25-31.
22. Martin, C.H., C.A. Mayeda, C.A. Davis, C.L. Ericsson, J.D. Knafels, D.R. Mathog, S.E. Celniker, E.B. Lewis, M.J. Palazzolo. 1995. Complete sequence of the bithorax complex of Drosophila. Proc. Natl. Acad. Sci. 92: 8398-8402.
23. Mihaly, J., J. Hogga, I. Gausz, H. Gyurkovics, and F. Karch. 1997. In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response element. Development 124: 1809-1820.
24. O'Donnell, K.H., C.T. Chen, and P.C. Wensink. 1994. Insulating DNA directs ubiquitous transcription of the Drosophila melanogaster alpha 1-tubulin gene. Mol. Cell. Biol. 14: 6398-6408.
25. Ohtsuki, S., M. Levine, and H.N. Cai. 1998. Different core promoters possess distinct regulatory activities in the Drosophila embryo. Genes & Dev. 12: 547-556.
26. Omichinski, J.G., P.V. Pedone, G. Felsenfcld, A.M. Gronenborn, and G.M. Clore. 1997. The solution structure of a specific GAGA factor-DNA complex reveals a modular binding mode. Nat. Struct. Biol. 4: 122-132.
27. Pick, L., A. Schier, M. Affolter, T. Schmidt-Glenewinkel, and W.J. Gehring. 1990. Analysis of the ftz upstream element: Germ layer-specific enhancers are independently autoregulated. Genes & Dev. 4: 1224-1239.
28. Schier, A.F. and W.J. Gehring. 1992. Direct homeodomain-DNA interaction in the autoregulation of the fushi tarazu gene. Nature 356: 804-807.
29. Scott, K.S. and P.K. Geyer. 1995. Effects of the su(Hw) insulator protein on the expression of the divergently transcribed Drosophila yolk protein genes. EMBO J. 14: 6258-6267.
30. Sharpe, J., S. Nonchev, A. Gould, J. Whiting, and R. Krumlauf. 1998. Selectivity, sharing and competitive interactions in the regulation of Hoxb genes. EMBO J. 17: 1788-1798.
31. Smale, S.T. 1997. Transcription initiation from TATA-less promoters within eukaryotic protein-coding genes. Biochim. Biophys. Acta. 1351: 73-88.
32. Small, S., A. Blair, and M. Levine. 1992. Regulation of even-skipped stripe 2 in the Drosophila embryo. EMBO J. 11: 4047-4057.
33. Tautz, D. and C. Pfeifle. 1989. A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma 98: 81-85.
34. Tsukiyama, T. and C. Wu. 1997. Chromatin remodeling and transcription. Curr. Opin. Genet. Dev. 7: 182-191.
35. Vasquez, J., G. Farkas, M. Gaszner, A. Udvardy, H. Muller, K. Hagstrom, H. Gyurkovics, L. Sipos, J. Gausz, M. Galloni, I. Hogga, F. Karch, and P. Schedl. 1993. Genetic and molecular analysis of chromatin domains. Cold Spring Harbor Symp. Quant. Biol. 58: 45-54.
36. Wilkins, R.C. and J.T. Lis. 1997. Dynamics of potentiation and activation: GAGA factor and its role in heat shock gene regulation. Nucleic Acids Res. 25: 3963-3968.
37. Zhou, J., S. Barolo, P. Szymanski, and M. Levine. 1996. The Fab-7 element of the bithorax complex attenuates enhancer-promoter interactions in the Drosophila embryo. Genes & Dev. 10: 3195-3201.