메뉴 건너뛰기




Volumn 19, Issue 3, 2002, Pages 295-299

p38 mitogen activated protein kinase as a therapeutic target for Alzheimer's disease

Author keywords

Alzheimer's disease; MAP kinase (MAPK); Neurofibrillary tangles (NFTs); P38; Tau

Indexed keywords

AMYLOID BETA PROTEIN; CYTOKINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; TAU PROTEIN;

EID: 0036922447     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:19:3:295     Document Type: Review
Times cited : (29)

References (37)
  • 3
    • 0035208849 scopus 로고    scopus 로고
    • Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis
    • Atzori C., Ghetti B., Piva R., Srinivasan A. N., Zolo P., Delisle M. B., et al. (2001) Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis. J. Neuropathol. Exp. Neurol. 60, 1190-1197.
    • (2001) J. Neuropathol. Exp. Neurol. , vol.60 , pp. 1190-1197
    • Atzori, C.1    Ghetti, B.2    Piva, R.3    Srinivasan, A.N.4    Zolo, P.5    Delisle, M.B.6
  • 4
    • 0030426902 scopus 로고    scopus 로고
    • Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function
    • Badger A. M., Bradbeer J. N., Votta B., Lee J. C., Adams J. L., and Griswold D. E. (1996) Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J. Pharmacol. Exp. Therap. 279, 1453-1461.
    • (1996) J. Pharmacol. Exp. Therap. , vol.279 , pp. 1453-1461
    • Badger, A.M.1    Bradbeer, J.N.2    Votta, B.3    Lee, J.C.4    Adams, J.L.5    Griswold, D.E.6
  • 5
    • 0035124607 scopus 로고    scopus 로고
    • Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia
    • Barone F. C., Irving E. A., Ray A. M., Lee J. C., Kassis S., Kumar S., et al. (2001) Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia. Med. Res. Rev. 21, 129-145.
    • (2001) Med. Res. Rev. , vol.21 , pp. 129-145
    • Barone, F.C.1    Irving, E.A.2    Ray, A.M.3    Lee, J.C.4    Kassis, S.5    Kumar, S.6
  • 6
    • 0037090078 scopus 로고    scopus 로고
    • Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia
    • Branger J., van den Blink B., Weijer S., Madwed J., Bos C. L., Gupta A., et al. (2002) Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia. J. Immunol. 168, 4070-4077.
    • (2002) J. Immunol. , vol.168 , pp. 4070-4077
    • Branger, J.1    Van den Blink, B.2    Weijer, S.3    Madwed, J.4    Bos, C.L.5    Gupta, A.6
  • 7
    • 0037181485 scopus 로고    scopus 로고
    • Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases in intact cells
    • Buee-Scherrer V. and Goedert M. (2002) Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases in intact cells. FEBS Lett. 515, 151-154.
    • (2002) FEBS Lett. , vol.515 , pp. 151-154
    • Buee-Scherrer, V.1    Goedert, M.2
  • 8
    • 0026075602 scopus 로고
    • Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene
    • Chartier-Harlin M. C., Crawford F., Houlden H., Warren A., Hughes D., Fidani L., et al. (1991) Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene. Nature 353, 844-846.
    • (1991) Nature , vol.353 , pp. 844-846
    • Chartier-Harlin, M.C.1    Crawford, F.2    Houlden, H.3    Warren, A.4    Hughes, D.5    Fidani, L.6
  • 9
    • 0035943345 scopus 로고    scopus 로고
    • A portrait of Alzheirmer secretases - New features and familiar faces
    • Esler W. P. and Wolfe M. S. (2001) A portrait of Alzheirmer secretases - New features and familiar faces. Science 293, 1449-1454.
    • (2001) Science , vol.293 , pp. 1449-1454
    • Esler, W.P.1    Wolfe, M.S.2
  • 10
    • 0035659377 scopus 로고    scopus 로고
    • Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies
    • Ferrer I., Blanco R., Carmona M., and Puig B. (2001) Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies. J. Neural Transm. 108, 1397-1415.
    • (2001) J. Neural Transm. , vol.108 , pp. 1397-1415
    • Ferrer, I.1    Blanco, R.2    Carmona, M.3    Puig, B.4
  • 11
    • 0035000643 scopus 로고    scopus 로고
    • Suppression of the clinical and cyotkine response to endotoxin by RWJ-67657, a p38 mitogen-activated protein-kinase inhibitor, in healthy human volunteers
    • Fijen J. W., Zijlstra J. G., De Boer P., Spanjersberg R., Cohen Tervaert J. W., Van der Werf T. S., et al. (2001) Suppression of the clinical and cyotkine response to endotoxin by RWJ-67657, a p38 mitogen-activated protein-kinase inhibitor, in healthy human volunteers. Clin. Exp. Immunol. 124, 16-20.
    • (2001) Clin. Exp. Immunol. , vol.124 , pp. 16-20
    • Fijen, J.W.1    Zijlstra, J.G.2    De Boer, P.3    Spanjersberg, R.4    Cohen Tervaert, J.W.5    Van der Werf, T.S.6
  • 12
    • 0026088977 scopus 로고
    • Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
    • Goate A., Chartier-Harlin M. C., Mullan M., Brown J., Crawford F., Fidani L., et al. (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349, 704-706.
    • (1991) Nature , vol.349 , pp. 704-706
    • Goate, A.1    Chartier-Harlin, M.C.2    Mullan, M.3    Brown, J.4    Crawford, F.5    Fidani, L.6
  • 13
    • 0030963035 scopus 로고    scopus 로고
    • Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases
    • Goedert M., Hasegawa M., Jakes R., Lawler S., Cuenda A., and Cohen P. (1997) Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases. FEBS Lett. 409, 57-62.
    • (1997) FEBS Lett. , vol.409 , pp. 57-62
    • Goedert, M.1    Hasegawa, M.2    Jakes, R.3    Lawler, S.4    Cuenda, A.5    Cohen, P.6
  • 15
    • 0032850020 scopus 로고    scopus 로고
    • p38 MAPK signalling cascades in inflammatory disease
    • Herlaar E. and Brown Z. (1999) p38 MAPK signalling cascades in inflammatory disease. Mol. Med. Today 5, 439-447.
    • (1999) Mol. Med. Today , vol.5 , pp. 439-447
    • Herlaar, E.1    Brown, Z.2
  • 16
    • 0036230270 scopus 로고    scopus 로고
    • Pathways of inflammatory activation in Alzheimer's disease: Potential targets for disease modifying drugs
    • Hull M., Lieb K., and Fiebich B. L. (2002) Pathways of inflammatory activation in Alzheimer's disease: Potential targets for disease modifying drugs. [review]. Curr. Med. Chem. 9, 83-88.
    • (2002) Curr. Med. Chem. , vol.9 , pp. 83-88
    • Hull, M.1    Lieb, K.2    Fiebich, B.L.3
  • 18
    • 0033230886 scopus 로고    scopus 로고
    • Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform
    • Ishihara T., Hong M., Zhang B., Nakagawa Y., Lee M. K., Trojanowski J. Q., and Lee V. M. (1999) Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. Neuron 24, 751-762.
    • (1999) Neuron , vol.24 , pp. 751-762
    • Ishihara, T.1    Hong, M.2    Zhang, B.3    Nakagawa, Y.4    Lee, M.K.5    Trojanowski, J.Q.6    Lee, V.M.7
  • 19
    • 0035134081 scopus 로고    scopus 로고
    • Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice
    • Ishihara T., Zhang B., Higuchi M., Yoshiyama Y., Trojanowski J. Q., and Lee V. M. (2001) Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice. Am. J. Pathol. 158, 555-562.
    • (2001) Am. J. Pathol. , vol.158 , pp. 555-562
    • Ishihara, T.1    Zhang, B.2    Higuchi, M.3    Yoshiyama, Y.4    Trojanowski, J.Q.5    Lee, V.M.6
  • 20
    • 0031934170 scopus 로고    scopus 로고
    • Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models
    • Jackson J. R., Bolognese B., Hillegass L., Kassis S., Adams J., Griswold D. E., et al. (1998) Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models. J. Pharmacol. Exp. Ther. 284, 687-692.
    • (1998) J. Pharmacol. Exp. Ther. , vol.284 , pp. 687-692
    • Jackson, J.R.1    Bolognese, B.2    Hillegass, L.3    Kassis, S.4    Adams, J.5    Griswold, D.E.6
  • 21
    • 0028605318 scopus 로고
    • A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
    • Lee J. C., McDonnell P. C., Gallagher T. F., Kumar S., Green D., McNulty D., et al. (1994) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372, 739-746.
    • (1994) Nature , vol.372 , pp. 739-746
    • Lee, J.C.1    McDonnell, P.C.2    Gallagher, T.F.3    Kumar, S.4    Green, D.5    McNulty, D.6
  • 23
    • 17944382037 scopus 로고    scopus 로고
    • Enhanced neurofibrillary degeneration in transgenic mice expressing mutant Tau and APP
    • Lewis J., Dickson D. W., Lin W.-L., Chrisholm L., Corral A., Jones G., et al. (2001) Enhanced neurofibrillary degeneration in transgenic mice expressing mutant Tau and APP. Science 293, 1487-1491.
    • (2001) Science , vol.293 , pp. 1487-1491
    • Lewis, J.1    Dickson, D.W.2    Lin, W.-L.3    Chrisholm, L.4    Corral, A.5    Jones, G.6
  • 24
    • 0032526423 scopus 로고    scopus 로고
    • Beta-amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes
    • McDonald D. R., Bamberger M. E., Combs C. K., and Landreth G. E. (1998) Beta-amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes. J. Neurosci. 18, 4451-4460.
    • (1998) J. Neurosci. , vol.18 , pp. 4451-4460
    • McDonald, D.R.1    Bamberger, M.E.2    Combs, C.K.3    Landreth, G.E.4
  • 25
    • 0034767903 scopus 로고    scopus 로고
    • Polymorphisms in inflammatory genes and the risk of Alzheimer disease
    • McGeer P. L. and McGeer E. G. (2001) Polymorphisms in inflammatory genes and the risk of Alzheimer disease. Arch. Neurol. 58, 1790-1792.
    • (2001) Arch. Neurol. , vol.58 , pp. 1790-1792
    • McGeer, P.L.1    McGeer, E.G.2
  • 26
    • 0025950987 scopus 로고
    • A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease
    • Murrell J., Farlow M., Ghetti B., and Benson M. D. (1991) A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science 254, 97-99.
    • (1991) Science , vol.254 , pp. 97-99
    • Murrell, J.1    Farlow, M.2    Ghetti, B.3    Benson, M.D.4
  • 27
    • 0028831582 scopus 로고
    • Relative roles of plaques and tangles in the dementia of Alzheimer's disease: Correlations using three sets of neuropathological criteria
    • Nagy Z., Esiri M. M., Jobst K. A., Morris J. H., King E. M., McDonald B., et al. (1995) Relative roles of plaques and tangles in the dementia of Alzheimer's disease: Correlations using three sets of neuropathological criteria. Dementia 6, 21-31.
    • (1995) Dementia , vol.6 , pp. 21-31
    • Nagy, Z.1    Esiri, M.M.2    Jobst, K.A.3    Morris, J.H.4    King, E.M.5    McDonald, B.6
  • 28
    • 0038117796 scopus 로고    scopus 로고
    • Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
    • Naslund J., Haroutunian V., Mohs R., Davis K. L., Davies P., Greengard P., et al. (2000) Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA 283, 1571-1577.
    • (2000) JAMA , vol.283 , pp. 1571-1577
    • Naslund, J.1    Haroutunian, V.2    Mohs, R.3    Davis, K.L.4    Davies, P.5    Greengard, P.6
  • 30
    • 0034067992 scopus 로고    scopus 로고
    • Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: Differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta
    • Reynolds C. H., Betts J. C., Blackstock W. P., Nebreda A. R., and Anderton B. H. (2000) Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: Differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta. J. Neurochem. 74, 1587-1595.
    • (2000) J. Neurochem. , vol.74 , pp. 1587-1595
    • Reynolds, C.H.1    Betts, J.C.2    Blackstock, W.P.3    Nebreda, A.R.4    Anderton, B.H.5
  • 31
    • 0029101491 scopus 로고
    • Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
    • Rogaev E. I., Sherrington R., Rogaeva E. A., Levesque G., Ikeda M., Liang Y., et al. (1995) Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376, 775-778.
    • (1995) Nature , vol.376 , pp. 775-778
    • Rogaev, E.I.1    Sherrington, R.2    Rogaeva, E.A.3    Levesque, G.4    Ikeda, M.5    Liang, Y.6
  • 33
    • 0036580703 scopus 로고    scopus 로고
    • Activation of c-jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition
    • Savage M. J., Lin Y.-G., Ciallella J. R., Flood C. G., and Scott R. W. (2002) Activation of c-jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition. J. Neurosci. 22, 3376-3385.
    • (2002) J. Neurosci. , vol.22 , pp. 3376-3385
    • Savage, M.J.1    Lin, Y.-G.2    Ciallella, J.R.3    Flood, C.G.4    Scott, R.W.5
  • 34
    • 0007692414 scopus 로고    scopus 로고
    • In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis
    • Sheng J. G., Ito K., Skinner R. D., Mrak R. E., Rovnaghi C. R., Van Eldik L. J., et al. (1996) In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis. Neurobiol. Aging 17, 761-766.
    • (1996) Neurobiol. Aging , vol.17 , pp. 761-766
    • Sheng, J.G.1    Ito, K.2    Skinner, R.D.3    Mrak, R.E.4    Rovnaghi, C.R.5    Van Eldik, L.J.6
  • 35
    • 0034814057 scopus 로고    scopus 로고
    • Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer's disease: Potential significance for tau protein phosphorylation
    • Sheng J. G., Jones R. A., Zhou X. Q., McGinness J. M., Van Eldik L. J., Mrak R. E., et al. (2001) Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer's disease: Potential significance for tau protein phosphorylation. Neurochem. Int. 39, 341-348.
    • (2001) Neurochem. Int. , vol.39 , pp. 341-348
    • Sheng, J.G.1    Jones, R.A.2    Zhou, X.Q.3    McGinness, J.M.4    Van Eldik, L.J.5    Mrak, R.E.6
  • 36
    • 0029004341 scopus 로고
    • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
    • Sherrington R., Rogaev E. I., Liang Y., Rogaeva E. A., Levesque G., Ikeda M., et al. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760.
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1    Rogaev, E.I.2    Liang, Y.3    Rogaeva, E.A.4    Levesque, G.5    Ikeda, M.6
  • 37
    • 0033782845 scopus 로고    scopus 로고
    • Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-r elated events in Alzheimer disease
    • Zhu X., Rottkamp C. A., Boux H., Takeda A., Perry G., and Smith M. A. (2000) Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-r elated events in Alzheimer disease. J. Neuropathol. Exp. 59, 880-888.
    • (2000) J. Neuropathol. Exp. , vol.59 , pp. 880-888
    • Zhu, X.1    Rottkamp, C.A.2    Boux, H.3    Takeda, A.4    Perry, G.5    Smith, M.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.