DNA and the immune system

Annals of Internal Medicine

Volumn 126, Issue 2, 1997, Pages 169-171

  Pisetsky, David S ^a,b  

^a DUKE UNIVERSITY   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; DNA; DNA VACCINE;

AUTOIMMUNITY; EDITORIAL; ETIOLOGY; IMMUNE SYSTEM; IMMUNITY; IMMUNOMODULATION; IMMUNOSTIMULATION; PRIORITY JOURNAL;

EID: 0031026644     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-126-2-199701150-00015     Document Type: Editorial

References (20)

1. Pisetsky DS. The immunologie properties of DNA. J Immunol. 1996: 156: 421-3.
2. Emlen W, Pisetsky DS, Taylor RP. Antibodies to DNA. A perspective. Arthritis Rheum. 1986: 29: 1417-26.
3. Madaio MP, Hodder S, Schwarte RS, Stellar BD. Responsiveness of autoimmune and normal mice to nucleic add antigens. J Immunol. 1984: 132: 872-6.
4. Tokunaga T, Yamamoto H, Shimada S, Abe H, Fukuda T, Fujisawa Y, et al. Antitumor activity of deoxyribonudeic acid fraction from Mycotecferium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. J Natl Cancer Inst. 1984: 72: 955-62.
5. Yamamoto S, Kuramoto E, Shimada S, Tokunaga T. In vitro augmentation of natural killer cell activity and production of interferon-α /β and -γ with deoxyribonudeic acid fraction from Mycobacterium bovis BCG. Jpn J Cancer Res. 1988: 79: 866-73.
6. Mashiba H, Matsunaga K, Tomoda H, Furusawa M, Jimi S, Tokunaga T. In vitro augmentation of natural killer activity of peripheral blood cells from cancer patients by a DNA fraction from Mycooacterium bovis BCG. Jpn J Med Sci Biol. 1988: 41: 197-202.
7. Tokunaga T, Yano O, Kuramoto E, Kimura Y, Yamamoto T, Kataoka T, et al. Synthetic oligonucleotides with particular base sequences from the cDNA encoding proteins of Mycobacterium bovis BCG induce interfé rons and activate natural killer cells. Microbiol Immunol. 1992: 36: 55-66.
8. Messina JP, Gilkeson GS, Pisetsky DS. Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. J Immunol. 1991: 147: 1759-64.
9. Krieg AM, Yi AK, Matson S, Waldschmidt TJ, Bishop GA, Teasdale R, et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature. 1995: 374: 546-9.
10. Klinman DM, Yi AK, Beaucage SL, Conover J, Krieg AM. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon 7. Proc Natl Acad Sci USA. 1996: 93: 2879-83.
11. Hergersberg M. Biological aspects of cytosine methylation in eukaryotic cells. Experientia. 1991; 47: 1171-85.
12. Haines DS. Strauss Kl, Gillespie DH. Cellular response to double-stranded RNA. J Cell Biochem. 1991; 46: 9-20.
13. Karounos DG, Grudier JP, Pisetsky DS. Spontaneous expression of antibodies to DNA of various species origin in sera of normal subjects and patients with systemic lupus erythematosus. J Immunol. 1988: 140: 451-5.
14. Robertson CR. Gilkeson GS, Ward MM. Pisetsky DS. Patterns of heavy and light chain utilization in the antibody response to single-stranded bacterial DNA in normal human subjects and patients with systemic lupus erythematosus. Clin Immunol Immunopathol. 1992: 62: 25-32.
15. Gilkeson GS, Rippen AM, Pisetsky DS. Induction of cross-reactive antidsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA. J Clin Invest. 1995: 95: 1398-402.
16. Zhao Q, Temsamani J, ladarola PL. Jiang Z, Agrawal S. Effect of different chemically modified oligodeoxynudeotides on immune stimulation. Biochem Pharmacol. 1996: 51: 173-82.
17. Tang DC, DeVit M, Johnston SA. Genetic immunization is a simple method for eliciting an immune response. Nature. 1992: 356: 152-4.
18. Ulmer JB, Donnelly II, Parker SE, Rhodes GH, Feigner PL, Dwarki VJ, et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science. 1993: 259: 1745-8.
19. Raz E, Tighe H. Sato Y, Con- M, Dudler JA, Roman M, et al. Preferential induction of a Th, immune response and inhibition of spedfic IgE antibody formation by plasmid DNA immunization. Proc Natl Acad Sd U S A. 1996: 93: 5141-5.
20. Sato Y, Roman M, Tighe H, Lee D, Corr M, Nguyen MD, et al. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science. 1996; 273: 352-4.