-
1
-
-
0036098242
-
Tissue stem cells: Definition, plasticity, heterogeneity, self- organization and models - A conceptual approach
-
Loeffler M., Roeder I. Tissue stem cells: definition, plasticity, heterogeneity, self- organization and models - a conceptual approach. Cells Tissues Organs. 171:2002;8-26.
-
(2002)
Cells Tissues Organs
, vol.171
, pp. 8-26
-
-
Loeffler, M.1
Roeder, I.2
-
2
-
-
0036517883
-
How cells change their phenotype
-
Tosh D., Slack J.M. How cells change their phenotype. Nat Rev Mol Cell Biol. 3:2002;187-194.
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 187-194
-
-
Tosh, D.1
Slack, J.M.2
-
3
-
-
0036274772
-
Plasticity of marrow-derived stem cells
-
Krause D.S. Plasticity of marrow-derived stem cells. Gene Ther. 9:2002;754-758.
-
(2002)
Gene Ther
, vol.9
, pp. 754-758
-
-
Krause, D.S.1
-
4
-
-
0035967892
-
The evolving concept of a stem cell: Entity or function?
-
Blau H.M., Brazelton T.R., Weimann J.M. The evolving concept of a stem cell: entity or function? Cell. 105:2001;829-841.
-
(2001)
Cell
, vol.105
, pp. 829-841
-
-
Blau, H.M.1
Brazelton, T.R.2
Weimann, J.M.3
-
6
-
-
0032489651
-
Muscle regeneration by bone marrow-derived myogenic progenitors
-
Ferrari G., Cusella-De Angelis G., Coletta M., Paolucci E., Stornaiuolo A., Cossu G., Mavilio F. Muscle regeneration by bone marrow-derived myogenic progenitors. Science. 279:1998;1528-1530.
-
(1998)
Science
, vol.279
, pp. 1528-1530
-
-
Ferrari, G.1
Cusella-De Angelis, G.2
Coletta, M.3
Paolucci, E.4
Stornaiuolo, A.5
Cossu, G.6
Mavilio, F.7
-
7
-
-
0033593654
-
Turning brain into blood: A hematopoietic fate adopted by adult neural stem cells in vivo
-
Bjornson C.R., Rietze R.L., Reynolds B.A., Magli M.C., Vescovi A.L. Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo. Science. 283:1999;534-537.
-
(1999)
Science
, vol.283
, pp. 534-537
-
-
Bjornson, C.R.1
Rietze, R.L.2
Reynolds, B.A.3
Magli, M.C.4
Vescovi, A.L.5
-
8
-
-
0034595855
-
Generalized potential of adult neural stem cells
-
Clarke D.L., Johansson C.B., Wilbertz J., Veress B., Nilsson E., Karlstrom H., Lendahl U., Frisen J. Generalized potential of adult neural stem cells. Science. 288:2000;1660-1663.
-
(2000)
Science
, vol.288
, pp. 1660-1663
-
-
Clarke, D.L.1
Johansson, C.B.2
Wilbertz, J.3
Veress, B.4
Nilsson, E.5
Karlstrom, H.6
Lendahl, U.7
Frisen, J.8
-
9
-
-
0034531907
-
From marrow to brain: Expression of neuronal phenotypes in adult mice
-
Brazelton T.R., Rossi F.M., Keshet G.I., Blau H.M. From marrow to brain: expression of neuronal phenotypes in adult mice. Science. 290:2000;1775-1779.
-
(2000)
Science
, vol.290
, pp. 1775-1779
-
-
Brazelton, T.R.1
Rossi, F.M.2
Keshet, G.I.3
Blau, H.M.4
-
10
-
-
0034532106
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Turning blood into brain: Cells bearing neuronal antigens generated in vivo from bone marrow
-
Mezey E., Chandross K.J., Harta G., Maki R.A., McKercher S.R. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science. 290:2000;1779-1782.
-
(2000)
Science
, vol.290
, pp. 1779-1782
-
-
Mezey, E.1
Chandross, K.J.2
Harta, G.3
Maki, R.A.4
McKercher, S.R.5
-
11
-
-
0033598374
-
Dystrophin expression in the mdx mouse restored by stem cell transplantation
-
Gussoni E., Soneoka Y., Strickland C.D., Buzney E.A., Khan M.K., Flint A.F., Kunkel L.M., Mulligan R.C. Dystrophin expression in the mdx mouse restored by stem cell transplantation. Nature. 401:1999;390-394.
-
(1999)
Nature
, vol.401
, pp. 390-394
-
-
Gussoni, E.1
Soneoka, Y.2
Strickland, C.D.3
Buzney, E.A.4
Khan, M.K.5
Flint, A.F.6
Kunkel, L.M.7
Mulligan, R.C.8
-
12
-
-
0033406436
-
Hematopoietic potential of stem cells isolated from murine skeletal muscle
-
Jackson K.A., Mi T., Goodell M.A. Hematopoietic potential of stem cells isolated from murine skeletal muscle. Proc Natl Acad Sci USA. 96:1999;14482-14486.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 14482-14486
-
-
Jackson, K.A.1
Mi, T.2
Goodell, M.A.3
-
13
-
-
0035889138
-
Identification of a candidate human neurohematopoietic stem-cell population
-
Shih C.C., Weng Y., Mamelak A., LeBon T., Hu M.C., Forman S.J. Identification of a candidate human neurohematopoietic stem-cell population. Blood. 98:2001;2412-2422.
-
(2001)
Blood
, vol.98
, pp. 2412-2422
-
-
Shih, C.C.1
Weng, Y.2
Mamelak, A.3
LeBon, T.4
Hu, M.C.5
Forman, S.J.6
-
14
-
-
0035273648
-
Stem cell dogmas in the genomics era
-
Lemischka I. Stem cell dogmas in the genomics era. Rev Clin Exp Hematol. 5:2001;15-25.
-
(2001)
Rev Clin Exp Hematol
, vol.5
, pp. 15-25
-
-
Lemischka, I.1
-
15
-
-
0034537289
-
Cell biology. Stem cells: New excitement, persistent questions
-
Vogel G. Cell biology. Stem cells: new excitement, persistent questions. Science. 290:2000;1672-1674.
-
(2000)
Science
, vol.290
, pp. 1672-1674
-
-
Vogel, G.1
-
16
-
-
0035182533
-
Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations
-
Weissman I.L., Anderson D.J., Gage F. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu Rev Cell Dev Biol. 17:2001;387-403.
-
(2001)
Annu Rev Cell Dev Biol
, vol.17
, pp. 387-403
-
-
Weissman, I.L.1
Anderson, D.J.2
Gage, F.3
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17
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0035496938
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Bone marrow origin of hematopoietic progenitors and stem cells in murine muscle
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In this report, the nature and origin of muscle-resident cells that display haematopoietic differentiation capacity was examined using clonal culture and transplantation techniques. Colony assays identify differences in the types and incidence of bone marrow (BM) and muscle-derived colonies. Transplantation experiments demonstrate that both muscle-resident haematopoietic progenitors and cells capable of long-term haematopoietic engraftment are of BM, rather than muscle, origin. On the basis of these data and mobilisation studies, the authors propose that haematopoietic progenitors and stem cells resident in muscle tissue are of BM origin, but their transition from BM to muscle may be a slow process. These results place significant constraints on the interpretations, with respect to plasticity, of previous reports demonstrating that mononuclear cells harvested from murine skeletal muscle are capable of haematopoietic reconstitution.
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Kawada H., Ogawa M. Bone marrow origin of hematopoietic progenitors and stem cells in murine muscle. Blood. 98:2001;2008-2013. In this report, the nature and origin of muscle-resident cells that display haematopoietic differentiation capacity was examined using clonal culture and transplantation techniques. Colony assays identify differences in the types and incidence of bone marrow (BM) and muscle-derived colonies. Transplantation experiments demonstrate that both muscle-resident haematopoietic progenitors and cells capable of long-term haematopoietic engraftment are of BM, rather than muscle, origin. On the basis of these data and mobilisation studies, the authors propose that haematopoietic progenitors and stem cells resident in muscle tissue are of BM origin, but their transition from BM to muscle may be a slow process. These results place significant constraints on the interpretations, with respect to plasticity, of previous reports demonstrating that mononuclear cells harvested from murine skeletal muscle are capable of haematopoietic reconstitution.
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(2001)
Blood
, vol.98
, pp. 2008-2013
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Kawada, H.1
Ogawa, M.2
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18
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0037022328
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Muscle-derived hematopoietic stem cells are hematopoietic in origin
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Previous results from this group (Jackson et al. 1999 [53]) demonstrating that mononuclear cells from murine skeletal muscle had the capacity to repopulate the haematopoietic systems of lethally irradiated mice engendered tremendous excitement, as they raised the possibility that muscle stem cells had differentiative plasticity. Here, the authors present evidence that the muscle-resident cells with haematopoietic engraftment capacity are of haematopoietic origin. It thus appears that discussion of transdifferentiation or plasticity mechanism is unwarranted in this case; instead, a simple explanation of haematopoietic stem cell distribution throughout the body might suffice.
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McKinney-Freeman S.L., Jackson K.A., Camargo F.D., Ferrari G., Mavilio F., Goodell M.A. Muscle-derived hematopoietic stem cells are hematopoietic in origin. Proc Natl Acad Sci USA. 99:2002;1341-1346. Previous results from this group (Jackson et al. 1999 [53]) demonstrating that mononuclear cells from murine skeletal muscle had the capacity to repopulate the haematopoietic systems of lethally irradiated mice engendered tremendous excitement, as they raised the possibility that muscle stem cells had differentiative plasticity. Here, the authors present evidence that the muscle-resident cells with haematopoietic engraftment capacity are of haematopoietic origin. It thus appears that discussion of transdifferentiation or plasticity mechanism is unwarranted in this case; instead, a simple explanation of haematopoietic stem cell distribution throughout the body might suffice.
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(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 1341-1346
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McKinney-Freeman, S.L.1
Jackson, K.A.2
Camargo, F.D.3
Ferrari, G.4
Mavilio, F.5
Goodell, M.A.6
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19
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0036213260
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Cells with hemopoietic potential residing in muscle are itinerant bone marrow-derived cells
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The authors characterise the nature of cells within muscle that possess haematopoietic reconstitution activity and explore their site of origin. Their data suggest a reinterpretation of previously published conclusions and argue that muscle-derived haematopoietic activity does not derive from the transdifferentiation of muscle cells but rather from the presence of bone-marrow-derived haematopoietic cells residing in muscle.
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Issarachai S., Priestley G.V., Nakamoto B., Papayannopoulou T. Cells with hemopoietic potential residing in muscle are itinerant bone marrow-derived cells. Exp Hematol. 30:2002;366-373. The authors characterise the nature of cells within muscle that possess haematopoietic reconstitution activity and explore their site of origin. Their data suggest a reinterpretation of previously published conclusions and argue that muscle-derived haematopoietic activity does not derive from the transdifferentiation of muscle cells but rather from the presence of bone-marrow-derived haematopoietic cells residing in muscle.
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(2002)
Exp Hematol
, vol.30
, pp. 366-373
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Issarachai, S.1
Priestley, G.V.2
Nakamoto, B.3
Papayannopoulou, T.4
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20
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0037100322
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Analysis of the hematopoietic potential of muscle-derived cells in mice
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These authors use in vitro and in vivo approaches to confirm the existence of a haematopoietic repopulating cell in muscle tissue but argue it reflects the presence on bona fide haematopoietic cells in muscle tissue rather a novel activity of muscle cells. They further demonstrate that blood-forming cells are enriched in muscle relative to their frequency in peripheral blood.
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Geiger H., True J.M., Grimes B., Carroll E.J., Fleischman R.A., Van Zant G. Analysis of the hematopoietic potential of muscle-derived cells in mice. Blood. 100:2002;721-723. These authors use in vitro and in vivo approaches to confirm the existence of a haematopoietic repopulating cell in muscle tissue but argue it reflects the presence on bona fide haematopoietic cells in muscle tissue rather a novel activity of muscle cells. They further demonstrate that blood-forming cells are enriched in muscle relative to their frequency in peripheral blood.
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(2002)
Blood
, vol.100
, pp. 721-723
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Geiger, H.1
True, J.M.2
Grimes, B.3
Carroll, E.J.4
Fleischman, R.A.5
Van Zant, G.6
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21
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0037041427
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Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion
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This group, along with Ying et al. (2002) [22••], caution that plasticity of stem cells may be a function of cell fusion. They co-cultured bone marrow cells with embryonic stem (ES) cells to obtain cells morphologically similar to ES cells in three weeks. Upon appropriate growth factor cues, these cells differentiated and displayed the characteristics of cells from all three germ layers. However, ploidy and karyotypic analysis revealed that the cells were tetraploid. Further, when transplanted in SCID mice, these cells could give rise to tumours.
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Terada N., Hamazaki T., Oka M., Hoki M., Mastalerz D.M., Nakano Y., Meyer E.M., Morel L., Petersen B.E., Scott E.W. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature. 416:2002;542-545. This group, along with Ying et al. (2002) [22••], caution that plasticity of stem cells may be a function of cell fusion. They co-cultured bone marrow cells with embryonic stem (ES) cells to obtain cells morphologically similar to ES cells in three weeks. Upon appropriate growth factor cues, these cells differentiated and displayed the characteristics of cells from all three germ layers. However, ploidy and karyotypic analysis revealed that the cells were tetraploid. Further, when transplanted in SCID mice, these cells could give rise to tumours.
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(2002)
Nature
, vol.416
, pp. 542-545
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Terada, N.1
Hamazaki, T.2
Oka, M.3
Hoki, M.4
Mastalerz, D.M.5
Nakano, Y.6
Meyer, E.M.7
Morel, L.8
Petersen, B.E.9
Scott, E.W.10
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22
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0037041428
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Changing potency by spontaneous fusion
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In this report, the authors used neural stem cells in co-culture with embryonic stem cells, which led to cell fusion and generated tetraploid hybrid cells. The hybrid cells were pluripotent and contributed to three lineages in chimaeric mice. Although no abnormalities were detected in the chimaeric animals, this report prompted a re-evaluation of previously reported instances of transdifferentiation.
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Ying Q.L., Nichols J., Evans E.P., Smith A.G. Changing potency by spontaneous fusion. Nature. 416:2002;545-548. In this report, the authors used neural stem cells in co-culture with embryonic stem cells, which led to cell fusion and generated tetraploid hybrid cells. The hybrid cells were pluripotent and contributed to three lineages in chimaeric mice. Although no abnormalities were detected in the chimaeric animals, this report prompted a re-evaluation of previously reported instances of transdifferentiation.
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(2002)
Nature
, vol.416
, pp. 545-548
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Ying, Q.L.1
Nichols, J.2
Evans, E.P.3
Smith, A.G.4
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23
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0036129310
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Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations
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In this study, Morshead et al. have attempted to reproduce original dogma-challenging studies in which neural stem cells (NSCs) were shown to have haematopoietic engraftment capacity. Despite an extensive study, which used an assay sufficiently sensitive to detect haematopoietic engraftment from even a single stem cell, contribution of neurosphere-derived cells to haematopoiesis was not observed. The authors conclude that haematopoietic competence is unlikely to be a consistent property of intravenously infused NSCs. The authors suggest that genetic or epigenetic alterations may occur during extended in vitro culture and that rare transformation events may account for the neural-to-blood fate switch originally reported.
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Morshead C.M., Benveniste P., Iscove N.N., van der Kooy D. Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations. Nat Med. 8:2002;268-273. In this study, Morshead et al. have attempted to reproduce original dogma-challenging studies in which neural stem cells (NSCs) were shown to have haematopoietic engraftment capacity. Despite an extensive study, which used an assay sufficiently sensitive to detect haematopoietic engraftment from even a single stem cell, contribution of neurosphere-derived cells to haematopoiesis was not observed. The authors conclude that haematopoietic competence is unlikely to be a consistent property of intravenously infused NSCs. The authors suggest that genetic or epigenetic alterations may occur during extended in vitro culture and that rare transformation events may account for the neural-to-blood fate switch originally reported.
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(2002)
Nat Med
, vol.8
, pp. 268-273
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Morshead, C.M.1
Benveniste, P.2
Iscove, N.N.3
Van der Kooy, D.4
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24
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0035805055
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Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell
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Krause D.S., Theise N.D., Collector M.I., Henegariu O., Hwang S., Gardner R., Neutzel S., Sharkis S.J. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell. 105:2001;369-377.
-
(2001)
Cell
, vol.105
, pp. 369-377
-
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Krause, D.S.1
Theise, N.D.2
Collector, M.I.3
Henegariu, O.4
Hwang, S.5
Gardner, R.6
Neutzel, S.7
Sharkis, S.J.8
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25
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0033694301
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Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
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Lagasse E., Connors H., Al-Dhalimy M., Reitsma M., Dohse M., Osborne L., Wang X., Finegold M., Weissman I.L., Grompe M. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med. 6:2000;1229-1234.
-
(2000)
Nat Med
, vol.6
, pp. 1229-1234
-
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Lagasse, E.1
Connors, H.2
Al-Dhalimy, M.3
Reitsma, M.4
Dohse, M.5
Osborne, L.6
Wang, X.7
Finegold, M.8
Weissman, I.L.9
Grompe, M.10
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26
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0035810240
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Bone marrow cells regenerate infarcted myocardium
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Orlic D., Kajstura J., Chimenti S., Jakoniuk I., Anderson S.M., Li B., Pickel J., McKay R., Nadal-Ginard B., Bodine D.M., et al. Bone marrow cells regenerate infarcted myocardium. Nature. 410:2001;701-705.
-
(2001)
Nature
, vol.410
, pp. 701-705
-
-
Orlic, D.1
Kajstura, J.2
Chimenti, S.3
Jakoniuk, I.4
Anderson, S.M.5
Li, B.6
Pickel, J.7
McKay, R.8
Nadal-Ginard, B.9
Bodine, D.M.10
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27
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0034988491
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Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells
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Jackson K.A., Majka S.M., Wang H., Pocius J., Hartley C.J., Majesky M.W., Entman M.L., Michael L.H., Hirschi K.K., Goodell M.A. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest. 107:2001;1395-1402.
-
(2001)
J Clin Invest
, vol.107
, pp. 1395-1402
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Jackson, K.A.1
Majka, S.M.2
Wang, H.3
Pocius, J.4
Hartley, C.J.5
Majesky, M.W.6
Entman, M.L.7
Michael, L.H.8
Hirschi, K.K.9
Goodell, M.A.10
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28
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0035525779
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Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells
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In this study, the authors describe the isolation, purification, expansion and phenotypic characterisation of cells co-purifying with mesenchymal stem cells and termed as mesodermal progenitor cells from human BM. Retrovirally marked and clonally expanded mesodermal progenitor cells could be induced to differentiate to a range of mesenchymal and mesodermal cell types in vitro. Importantly, the authors show that mesodermal progenitor cells lost their plasticity upon differentiation. Detailed conditions for expansion and differentiation are described which form the basis for their experiments with murine, rat and human multipotent adult progenitor cells, as described in Jiang et al. (2002) [29••].
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Reyes M., Lund T., Lenvik T., Aguiar D., Koodie L., Verfaillie C.M. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood. 98:2001;2615-2625. In this study, the authors describe the isolation, purification, expansion and phenotypic characterisation of cells co-purifying with mesenchymal stem cells and termed as mesodermal progenitor cells from human BM. Retrovirally marked and clonally expanded mesodermal progenitor cells could be induced to differentiate to a range of mesenchymal and mesodermal cell types in vitro. Importantly, the authors show that mesodermal progenitor cells lost their plasticity upon differentiation. Detailed conditions for expansion and differentiation are described which form the basis for their experiments with murine, rat and human multipotent adult progenitor cells, as described in Jiang et al. (2002) [29••].
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(2001)
Blood
, vol.98
, pp. 2615-2625
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Reyes, M.1
Lund, T.2
Lenvik, T.3
Aguiar, D.4
Koodie, L.5
Verfaillie, C.M.6
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29
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0037019337
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Pluripotency of mesenchymal stem cells derived from adult marrow
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These studies show that the cells co-purifying with mesenchymal stem cells can, after approximately 30 doublings in culture, give rise to cells termed multipotent adult progenitor cells that resemble embryonic stem cells. Multipotent adult progenitor cells appear stable in culture and can contribute to a very broad spectrum of mature cell populations. The nature of the 'founding' cell that gives rise to multipotent adult progenitor cells remains unclear. Multipotent adult progenitor cells may be adult cells that dedifferentiate in culture to become multipotent, or may instead represent a rare class of quasi-universal stem cells that persist throughout the body. The fact that starting populations of primary cells must be cultured at length before multipotent adult progenitor cell activity is apparent tends to argue that they are an artefact of culture. This may not prejudice their use in cell-based therapy, providing sufficient caution is taken to ensure their long-term stability.
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Jiang Y., Jahagirdar B.N., Reinhardt R.L., Schwartz R.E., Keene C.D., Ortiz-Gonzalez X.R., Reyes M., Lenvik T., Lund T., Blackstad M., et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 418:2002;41-49. These studies show that the cells co-purifying with mesenchymal stem cells can, after approximately 30 doublings in culture, give rise to cells termed multipotent adult progenitor cells that resemble embryonic stem cells. Multipotent adult progenitor cells appear stable in culture and can contribute to a very broad spectrum of mature cell populations. The nature of the 'founding' cell that gives rise to multipotent adult progenitor cells remains unclear. Multipotent adult progenitor cells may be adult cells that dedifferentiate in culture to become multipotent, or may instead represent a rare class of quasi-universal stem cells that persist throughout the body. The fact that starting populations of primary cells must be cultured at length before multipotent adult progenitor cell activity is apparent tends to argue that they are an artefact of culture. This may not prejudice their use in cell-based therapy, providing sufficient caution is taken to ensure their long-term stability.
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(2002)
Nature
, vol.418
, pp. 41-49
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Jiang, Y.1
Jahagirdar, B.N.2
Reinhardt, R.L.3
Schwartz, R.E.4
Keene, C.D.5
Ortiz-Gonzalez, X.R.6
Reyes, M.7
Lenvik, T.8
Lund, T.9
Blackstad, M.10
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30
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0036106054
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Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells
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In this report, the authors extend their studies with multipotent adult progenitor cells and describe details of hepatocytic differentiation of multipotent adult progenitor cells.
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Schwartz R.E., Reyes M., Koodie L., Jiang Y., Blackstad M., Lund T., Lenvik T., Johnson S., Hu W.S., Verfaillie C.M. Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest. 109:2002;1291-1302. In this report, the authors extend their studies with multipotent adult progenitor cells and describe details of hepatocytic differentiation of multipotent adult progenitor cells.
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(2002)
J Clin Invest
, vol.109
, pp. 1291-1302
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Schwartz, R.E.1
Reyes, M.2
Koodie, L.3
Jiang, Y.4
Blackstad, M.5
Lund, T.6
Lenvik, T.7
Johnson, S.8
Hu, W.S.9
Verfaillie, C.M.10
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31
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0036322544
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Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain
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This is the latest of the reports on multipotent adult progenitor cells. The authors describe the discovery of multipotent adult progenitor-cell-like cells from neural and muscle tissue and their differentiation to multiple lineages. This study indicates that potentially plastic cells isolated from various tissues could probably be derivatives of or are itinerant multipotent adult progenitor cells resident in these tissues.
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Jiang Y., Vaessen B., Lenvik T., Blackstad M., Reyes M., Verfaillie C. Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. Exp Hematol. 30:2002;896. This is the latest of the reports on multipotent adult progenitor cells. The authors describe the discovery of multipotent adult progenitor-cell-like cells from neural and muscle tissue and their differentiation to multiple lineages. This study indicates that potentially plastic cells isolated from various tissues could probably be derivatives of or are itinerant multipotent adult progenitor cells resident in these tissues.
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(2002)
Exp Hematol
, vol.30
, pp. 896
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Jiang, Y.1
Vaessen, B.2
Lenvik, T.3
Blackstad, M.4
Reyes, M.5
Verfaillie, C.6
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32
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0033756981
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Stem cell plasticity in mammals and transdetermination in Drosophila: Common themes?
-
Wei G., Schubiger G., Harder F., Muller A.M. Stem cell plasticity in mammals and transdetermination in Drosophila: common themes? Stem Cells. 18:2000;409-414.
-
(2000)
Stem Cells
, vol.18
, pp. 409-414
-
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Wei, G.1
Schubiger, G.2
Harder, F.3
Muller, A.M.4
-
33
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0036255131
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Not your father's planarian: A classic model enters the era of functional genomics
-
Newmark P.A., Alvarado A.S. Not your father's planarian: a classic model enters the era of functional genomics. Nat Rev Genet. 3:2002;210-219.
-
(2002)
Nat Rev Genet
, vol.3
, pp. 210-219
-
-
Newmark, P.A.1
Alvarado, A.S.2
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34
-
-
0035810962
-
Mammalian postmitotic nuclei reenter the cell cycle after serum stimulation in newt/mouse hybrid myotubes
-
Velloso C.P., Simon A., Brockes J.P. Mammalian postmitotic nuclei reenter the cell cycle after serum stimulation in newt/mouse hybrid myotubes. Curr Biol. 11:2001;855-858.
-
(2001)
Curr Biol
, vol.11
, pp. 855-858
-
-
Velloso, C.P.1
Simon, A.2
Brockes, J.P.3
-
35
-
-
0035923683
-
Mammalian myotube dedifferentiation induced by newt regeneration extract
-
In this report, the authors show that extracts from regenerating newt limbs could induce cell cycle re-entry in 25% of postmitotic newt myotubes and 18% of murine myotubes. The dedifferentiation was accompanied by reduction in myogenic proteins and cellular cleavage. These results indicate the innate ability of postmitotic differentiated cells to sense and respond to exogenous dedifferentiating factors from microenvironment.
-
McGann C.J., Odelberg S.J., Keating M.T. Mammalian myotube dedifferentiation induced by newt regeneration extract. Proc Natl Acad Sci USA. 98:2001;13699-13704. In this report, the authors show that extracts from regenerating newt limbs could induce cell cycle re-entry in 25% of postmitotic newt myotubes and 18% of murine myotubes. The dedifferentiation was accompanied by reduction in myogenic proteins and cellular cleavage. These results indicate the innate ability of postmitotic differentiated cells to sense and respond to exogenous dedifferentiating factors from microenvironment.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 13699-13704
-
-
McGann, C.J.1
Odelberg, S.J.2
Keating, M.T.3
-
36
-
-
0034622930
-
Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells
-
Kondo T., Raff M. Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science. 289:2000;1754-1757.
-
(2000)
Science
, vol.289
, pp. 1754-1757
-
-
Kondo, T.1
Raff, M.2
-
37
-
-
0024381667
-
Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD
-
Weintraub H., Tapscott S.J., Davis R.L., Thayer M.J., Adam M.A., Lassar A.B., Miller A.D. Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. Proc Natl Acad Sci USA. 86:1989;5434-5438.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 5434-5438
-
-
Weintraub, H.1
Tapscott, S.J.2
Davis, R.L.3
Thayer, M.J.4
Adam, M.A.5
Lassar, A.B.6
Miller, A.D.7
-
38
-
-
0033672199
-
Molecular basis of transdifferentiation of pancreas to liver
-
Shen C.N., Slack J.M., Tosh D. Molecular basis of transdifferentiation of pancreas to liver. Nat Cell Biol. 2:2000;879-887.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 879-887
-
-
Shen, C.N.1
Slack, J.M.2
Tosh, D.3
-
39
-
-
0034637103
-
Inhibition of adipogenesis by Wnt signaling
-
Ross S.E., Hemati N., Longo K.A., Bennett C.N., Lucas P.C., Erickson R.L., MacDougald O.A. Inhibition of adipogenesis by Wnt signaling. Science. 289:2000;950-953.
-
(2000)
Science
, vol.289
, pp. 950-953
-
-
Ross, S.E.1
Hemati, N.2
Longo, K.A.3
Bennett, C.N.4
Lucas, P.C.5
Erickson, R.L.6
MacDougald, O.A.7
-
40
-
-
0035545995
-
Pax6 lights-up the way for eye development
-
Ashery-Padan R., Gruss P. Pax6 lights-up the way for eye development. Curr Opin Cell Biol. 13:2001;706-714.
-
(2001)
Curr Opin Cell Biol
, vol.13
, pp. 706-714
-
-
Ashery-Padan, R.1
Gruss, P.2
-
41
-
-
0037025198
-
Reversion of B cell commitment upon loss of Pax5 expression
-
In an extension of their earlier work, this laboratory uses a conditional knockout strategy to demonstrate a requirement for Pax5 to both initiate and maintain a B lymphoid transcription programme.
-
Mikkola I., Heavey B., Horcher M., Busslinger M. Reversion of B cell commitment upon loss of Pax5 expression. Science. 297:2002;110-113. In an extension of their earlier work, this laboratory uses a conditional knockout strategy to demonstrate a requirement for Pax5 to both initiate and maintain a B lymphoid transcription programme.
-
(2002)
Science
, vol.297
, pp. 110-113
-
-
Mikkola, I.1
Heavey, B.2
Horcher, M.3
Busslinger, M.4
-
42
-
-
0037099497
-
Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells
-
Many studies of experimentally induced cell-type switching use transformed cell lines, making it difficult to exclude the possibility that the observed plasticity is a function of transformation per se. Using primary GM-committed progenitors, these authors show that ectopic expression of a single transcription factor (GATA-1) achieves a radical reprogramming of cell fate output. Importantly, clone marking and daughter cell experiments identified lineage switching rather than differential cell output as the mechanism of altered lineage output. Whether transdifferentiation or dedifferentiation of GM-progenitors underlies GATA-1-mediated cell-type reprogramming is not clear from these studies.
-
Heyworth C., Pearson S., May G., Enver T. Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells. EMBO J. 21:2002;3770-3781. Many studies of experimentally induced cell-type switching use transformed cell lines, making it difficult to exclude the possibility that the observed plasticity is a function of transformation per se. Using primary GM-committed progenitors, these authors show that ectopic expression of a single transcription factor (GATA-1) achieves a radical reprogramming of cell fate output. Importantly, clone marking and daughter cell experiments identified lineage switching rather than differential cell output as the mechanism of altered lineage output. Whether transdifferentiation or dedifferentiation of GM-progenitors underlies GATA-1-mediated cell-type reprogramming is not clear from these studies.
-
(2002)
EMBO J
, vol.21
, pp. 3770-3781
-
-
Heyworth, C.1
Pearson, S.2
May, G.3
Enver, T.4
-
43
-
-
0037013877
-
Essential and instructive roles of GATA factors in eosinophil development
-
In this study, enforced expression of GATA-1 in primary CD34 positive human myeloid progenitors derived from umbilical cord blood promotes eosinophil commitment and supports their terminal differentiation. These data argue for an instructive role for GATA-1 in eosinophil commitment.
-
Hirasawa R., Shimizu R., Takahashi S., Osawa M., Takayanagi S., Kato Y., Onodera M., Minegishi N., Yamamoto M., Fukao K., et al. Essential and instructive roles of GATA factors in eosinophil development. J Exp Med. 195:2002;1379-1386. In this study, enforced expression of GATA-1 in primary CD34 positive human myeloid progenitors derived from umbilical cord blood promotes eosinophil commitment and supports their terminal differentiation. These data argue for an instructive role for GATA-1 in eosinophil commitment.
-
(2002)
J Exp Med
, vol.195
, pp. 1379-1386
-
-
Hirasawa, R.1
Shimizu, R.2
Takahashi, S.3
Osawa, M.4
Takayanagi, S.5
Kato, Y.6
Onodera, M.7
Minegishi, N.8
Yamamoto, M.9
Fukao, K.10
-
44
-
-
0037062515
-
In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells
-
Highly purified rat hepatic oval stem cells were transdifferentiated into pancreatic cells upon culturing in high-glucose medium. The transdifferentiated cells secrete insulin, express pancreatic molecular markers and even self-assemble to form three-dimensional islet-cell-like clusters. Further, these islet-like clusters displayed ability to reverse hyperglycemia in diabetic NOD/SCID mouse model, indicating their possible use in therapy of diabetes.
-
Yang L., Li S., Hatch H., Ahrens K., Cornelius J.G., Petersen B.E., Peck A.B. In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells. Proc Natl Acad Sci USA. 99:2002;8078-8083. Highly purified rat hepatic oval stem cells were transdifferentiated into pancreatic cells upon culturing in high-glucose medium. The transdifferentiated cells secrete insulin, express pancreatic molecular markers and even self-assemble to form three-dimensional islet-cell-like clusters. Further, these islet-like clusters displayed ability to reverse hyperglycemia in diabetic NOD/SCID mouse model, indicating their possible use in therapy of diabetes.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 8078-8083
-
-
Yang, L.1
Li, S.2
Hatch, H.3
Ahrens, K.4
Cornelius, J.G.5
Petersen, B.E.6
Peck, A.B.7
-
45
-
-
0035899505
-
Purification of a pluripotent neural stem cell from the adult mouse brain
-
This study reports that prospectively isolated primary neural stem cells (NSCs), when co-cultured with differentiating myotubes in vitro, could differentiate into myocytes and express some myogenic proteins. The differentiation of NSC to muscle-like cells occurs at a frequency as high as 50%. The probability of fusion is not addressed, however.
-
Rietze R.L., Valcanis H., Brooker G.F., Thomas T., Voss A.K., Bartlett P.F. Purification of a pluripotent neural stem cell from the adult mouse brain. Nature. 412:2001;736-739. This study reports that prospectively isolated primary neural stem cells (NSCs), when co-cultured with differentiating myotubes in vitro, could differentiate into myocytes and express some myogenic proteins. The differentiation of NSC to muscle-like cells occurs at a frequency as high as 50%. The probability of fusion is not addressed, however.
-
(2001)
Nature
, vol.412
, pp. 736-739
-
-
Rietze, R.L.1
Valcanis, H.2
Brooker, G.F.3
Thomas, T.4
Voss, A.K.5
Bartlett, P.F.6
-
46
-
-
0036333788
-
The meso-angioblast: A multipotent, self-renewing cell that originates from the dorsal aorta and differentiates into most mesodermal tissues
-
Quail or mouse embryonic aorta transplanted into host chick embryos gave rise to multiple mesodermal tissues including blood, cartilage, bone smooth, skeletal and cardiac muscle. Culturing on fibroblastic feeder layers allowed clonal proliferation, acquisition of unlimited lifespan and retention of multipotency. The cells exhibited haemo-angioblastic cell surface markers. The authors term these vessel-associated cells 'meso-angioblasts' and speculate that they participate in postembryonic mesoderm development. Although the authors have provided compelling evidence for the existence of postnatal stem cells with these properties relatively early in the lifetime of an organism, it remains unclear to what extent such persist into adulthood proper.
-
Minasi M.G., Riminucci M., De Angelis L., Borello U., Berarducci B., Innocenzi A., Caprioli A., Sirabella D., Baiocchi M., De Maria R., et al. The meso-angioblast: a multipotent, self-renewing cell that originates from the dorsal aorta and differentiates into most mesodermal tissues. Development. 129:2002;2773-2783. Quail or mouse embryonic aorta transplanted into host chick embryos gave rise to multiple mesodermal tissues including blood, cartilage, bone smooth, skeletal and cardiac muscle. Culturing on fibroblastic feeder layers allowed clonal proliferation, acquisition of unlimited lifespan and retention of multipotency. The cells exhibited haemo-angioblastic cell surface markers. The authors term these vessel-associated cells 'meso-angioblasts' and speculate that they participate in postembryonic mesoderm development. Although the authors have provided compelling evidence for the existence of postnatal stem cells with these properties relatively early in the lifetime of an organism, it remains unclear to what extent such persist into adulthood proper.
-
(2002)
Development
, vol.129
, pp. 2773-2783
-
-
Minasi, M.G.1
Riminucci, M.2
De Angelis, L.3
Borello, U.4
Berarducci, B.5
Innocenzi, A.6
Caprioli, A.7
Sirabella, D.8
Baiocchi, M.9
De Maria, R.10
-
47
-
-
0036225224
-
Hematopoiesis and stem cells: Plasticity versus developmental heterogeneity
-
Orkin S.H., Zon L.I. Hematopoiesis and stem cells: plasticity versus developmental heterogeneity. Nat Immunol. 3:2002;323-328.
-
(2002)
Nat Immunol
, vol.3
, pp. 323-328
-
-
Orkin, S.H.1
Zon, L.I.2
-
48
-
-
0035499267
-
Stem cells, cancer, and cancer stem cells
-
Reya T., Morrison S.J., Clarke M.F., Weissman I.L. Stem cells, cancer, and cancer stem cells. Nature. 414:2001;105-111.
-
(2001)
Nature
, vol.414
, pp. 105-111
-
-
Reya, T.1
Morrison, S.J.2
Clarke, M.F.3
Weissman, I.L.4
-
49
-
-
0032504051
-
Loops, lineage, and leukemia
-
Enver T., Greaves M. Loops, lineage, and leukemia. Cell. 94:1998;9-12.
-
(1998)
Cell
, vol.94
, pp. 9-12
-
-
Enver, T.1
Greaves, M.2
-
50
-
-
0036261049
-
Malignant biphasic uterine tumours: Carcinosarcomas or metaplastic carcinomas?
-
McCluggage W.G. Malignant biphasic uterine tumours: carcinosarcomas or metaplastic carcinomas? J Clin Pathol. 55:2002;321-325.
-
(2002)
J Clin Pathol
, vol.55
, pp. 321-325
-
-
McCluggage, W.G.1
-
51
-
-
0036561903
-
Malignant teratocarcinosarcoma of the nose and paranasal sinuses
-
Gadban H, Talmon Y, Samet A, Cohen I: Malignant teratocarcinosarcoma of the nose and paranasal sinuses. Harefuah 2002, 141: 430-432, 499.
-
(2002)
Harefuah
, vol.141
, pp. 430-432
-
-
Gadban H1
Talmon Y2
Samet A3
Cohen, I.4
-
52
-
-
0037186519
-
Monoclonal mice generated by nuclear transfer from mature B and T donor cells
-
Using nuclei derived from adult B and T lymphocytes, these authors provide an unequivocal demonstration that a terminally differentiated cell can be reprogrammed to produce an adult animal.
-
Hochedlinger K., Jaenisch R. Monoclonal mice generated by nuclear transfer from mature B and T donor cells. Nature. 415:2002;1035-1038. Using nuclei derived from adult B and T lymphocytes, these authors provide an unequivocal demonstration that a terminally differentiated cell can be reprogrammed to produce an adult animal.
-
(2002)
Nature
, vol.415
, pp. 1035-1038
-
-
Hochedlinger, K.1
Jaenisch, R.2
-
53
-
-
0033406436
-
Hematopoietic potential of stem cells isolated from murine skeletal muscle
-
Jackson K.A., Mi T., Goodell M.A. Hematopoietic potential of stem cells isolated from murine skeletal muscle. Proc Natl Acad Sci USA. 96:1999;14482-14486.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 14482-14486
-
-
Jackson, K.A.1
Mi, T.2
Goodell, M.A.3
-
54
-
-
0037183884
-
Little evidence for developmental plasticity of adult hematopoietic stem cells
-
10.1126/science.1074807
-
Wagers AJ, Sherwood RI, Christensen JL, Weissman IL: Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 2002, 10.1126/science.1074807.
-
(2002)
Science
-
-
Wagers, A.J.1
Sherwood, R.I.2
Christensen, J.L.3
Weissman, I.L.4
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