Hematopoiesis and stem cells: Plasticity versus development heterogeneity

Nature Immunology

Volumn 3, Issue 4, 2002, Pages 323-328

  Orkin, Stuart H ^a   Zon, Leonard I ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; ANIMAL CELL; CELL DIFFERENTIATION; CELL HETEROGENEITY; CELL POPULATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; MOUSE; NONHUMAN; PLASTICITY; PRIORITY JOURNAL; REVIEW;

ANIMALS; CELL DIFFERENTIATION; ENDOTHELIUM, VASCULAR; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; MESODERM; YOLK SAC;

EID: 0036225224     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni0402-323     Document Type: Review

References (71)

1. Development of the hematopoietic system
2. Diversification of haematopoietic stem cells to specific lineages
3. Bone morphogenetic protein-4 (BMP-4) is required for mesoderm formation and patterning in the mouse
4. The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning
5. Relationship between vasculogenesis, angiogenesis, and haemopoiesis during avian ontogeny
6. A common precursor for hematopoietic and endothelial cells
7. The SCL gene specifies haemangioblast development from early mesoderm
8. A common precursor for primitive erythropoiesis and definitive hematopoiesis
9. Clonal analysis of differentiating embryonic stem cells reveals a hematopoietic progenitor with primitive erythroid an adult lymphoid-myeloid potential
10. Erythropoiesis and lymphopoiesis in the chick yolk-sac-embryo chimeras: Contribution of yolk sac and intraembryonic stem cells
11. Bipotential primitive-definitive hematopoietic progenitors in the vertebrate embryo
12. Intraembryonic origin of hepatic hematopoiesis in Xenopus laevis
13. Dual contribution of embryonic ventral blood island and dorsal lateral plate mesoderm during ontogeny of hemopoietic cells in Xenopus laevis
14. An early pre-liver intraembryonic source of CFU-S in the developing mouse
15. Evidence for the hemogenic capacity of endothelium
16. Tissue cultures of young mammalian embryos
17. + hematopoietic cells in the early human embryo
18. Cbfa2 is required for the formation of intra-aortic hematopoietic clusters
19. Ontogeny of the haemopoietic system: Yolk sac origin of in vivo and in vitro colony forming cells in the developing mouse embryo
20. Hemopoietic stem cells in murine embryonic yolk sac and peripheral blood
21. Definitive hematopoiesis is autonomously initiated by the AGM region
22. Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac
23. In vivo repopulating hematopoietic stem cells are present in the murine yolk sac at day 9.0 postcoitus
24. Murine yolk sac and bone marrow hematopoietic cells with high proliferative potential display different capacities for producing colony-forming cells ex vivo
25. Generation of definitive hematopoietic stem cells from murine early yolk sac and paraaortic splanchnopleures by aorta-gonad-mesonephros region-derived stromal cells
26. Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo
27. Distinct origins of adult and embryonic blood in Xenopus
28. The origin of lymphoid stem cells studied in chick yolk sac-embryo chimaeras
29. Functional heterogeneity of the hematopoietic microenvironment: Rare stromal elements maintain long-term repopulating stem cells
30. - progenitors to maintain primitive function and immunophenotype in vitro
31. Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs
32. Bone morphogenetic proteins regulate the developmental program of human hematopoietic stem cells
33. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation
34. Winged-helix, Hedgehog and Bmp genes are differentially expressed in distinct cell layers of the murine yolk sac
35. Role of members of the Wnt gene family in human hematopoiesis
36. Signaling through the interaction of membrane-restricted stem cell factor and c-kit receptor tyrosine kinase: Genetic evidence for a differential role in erythropoiesis
37. Stromal support augments extended long-term ex vivo expansion of hemopoietic progenitor cells
38. 2-integrins and selectins
39. null mice
40. CXCR-4 desensitization is associated with tissue localization of hemopoietic progenitor cells
41. In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos
42. Manipulation of the angiopoietic/hemangiopoietic commitment in the avian embryo
43. Intraaortic hemopoietic cells are derived from endothelial cells during ontogeny
44. The splanchnopleura/AGM region is the prime site for the generation of multipotent hemopoietic precursors, in the mouse embryo
45. Blood-borne seeding by hematopoietic and endothelial precursors from the allantois
46. CD34 expression patterns during early mouse development are related to modes of blood vessel formation and reveal additional sites of hematopoiesis
47. Gridlock signalling pathway fashions the first embryonic artery
48. Translating stem and progenitor cell biology to the clinic: Barriers and opportunities
49. Hematopoietic potential of stem cells isolated from murine skeletal muscle
50. Dystrophin expression in the mdx mouse restored by stem cell transplantation
51. Purified hematopoietic stem cells can differentiate to hepatocytes in vivo
52. Stem cell alchemy
53. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell
54. Transplanted adult bone marrow cells repair myocardial infarcts in mice
55. Bone marrow cells regenerate infarcted myocardium
56. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells
57. Mobilized bone marrow cells repair the infarcted heart, improving function and survival
58. Hemopoietic lineage switch: v-raf oncogene converts Eμ-myc transgenic B cells into macrophages
59. Plasticity of hematopoietic cells
60. Bone marrow origin of hematopoietic progenitors and stem cells in murine muscle
61. Muscle-derived hematopoietic stem cells are hematopoietic in origin
62. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
63. Physiological migration of hematopoietic stem and progenitor cells
64. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo
65. Reversible expression of CD34 by murine hematopoietic stem cells
66. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells
67. Stromal bone marrow cells and the hematopoietic microenvironment
68. Multilineage potential of adult human mesenchymal stem cells