A mycobacterial iron chelator, desferri-exochelin, induces hypoxia-inducible factors 1 and 2, NIP3, and vascular endothelial growth factor in cancer cell lines

Cancer Research

Volumn 62, Issue 23, 2002, Pages 6924-6927

  Wen Chong, Tsung ^a   Horwitz, Lawrence D ^b   Moore, John W ^a   Sowter, Heidi M ^a   Harris, Adrian L ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEFEROXAMINE; DESFERRI EXOCHELIN; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 2; IRON; IRON CHELATE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VASCULOTROPIN;

ARTICLE; BREAST TUMOR; CANCER CELL; CANCER THERAPY; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG POTENCY; ENDOTHELIUM CELL; FEMALE; GENE TARGETING; GROWTH INHIBITION; HUMAN; HUMAN CELL; HYPOXIA; MYCOBACTERIUM; PRIORITY JOURNAL; TUMOR CELL;

ADENOCARCINOMA; ANGIOGENESIS INHIBITORS; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BREAST NEOPLASMS; CELL DIVISION; CHO CELLS; CRICETINAE; DEFEROXAMINE; DNA-BINDING PROTEINS; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; IRON CHELATING AGENTS; LYMPHOKINES; MEMBRANE PROTEINS; NUCLEAR PROTEINS; PEPTIDES, CYCLIC; PROTO-ONCOGENE PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0036897079     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Semenza, G. L. HIF-1 and mechanisms of hypoxia sensing. Curr. Opin. Cell Biol., 13: 167-171, 2001.
2. Wang, G. L., and Semenza, G. L. Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: Implications for models of hypoxia signal transduction. Blood, 82: 3610-3615, 1993.
3. Wenger, R. H. Mammalian oxygen sensing, signalling, and gene regulation. J. Exp. Biol., 203 (Pt. 8): 1253-1263, 2000.
4. 2 sensing. Science (Wash. DC), 292: 464-468, 2001.
5. 2-regulated prolyl hydroxylation. Science (Wash. DC), 292: 468-472, 2001.
6. Gobin, J., Moore, C. H., Reeve, J. R., Wong, D. K., Gibson, B. W., and Horwitz, M. A. Iron acquisition by Mycobacterium tuberculosis: Isolation and characterization of a family of iron-binding exochelins. Proc. Natl. Acad. Sci. USA, 92: 5189-5193, 1995.
7. Gobin, J., and Horwitz, M. A. Exochelins of Mycobacterium tuberculosis remove iron from human iron-binding proteins and donate iron to mycobactins in the M. tuberculosis cell wall. J. Exp. Med., 183: 1527-1532, 1996.
8. Gobin, J., Wong, D. K., Gibson, B. W., and Horwitz, M. A. Characterization of exochelins of the Mycobacterium bovis type strain and BCG substrains. Infect. Immun., 67: 2035-2039, 1999.
9. Horwitz, L. D., Sherman, N. A., Kong, Y., Pike, A. W., Gobin, J., Fennessey, P. V., and Horwitz, M. A. Lipophilic siderophores of Mycobacterium tuberculosis prevent cardiac reperfusion injury. Proc. Natl. Acad. Sci. USA, 95: 5263-5268, 1998.
10. Pahl, P. M. B., Yan. X-D., Hodges, Y. K., Rosenthal, E. A., Horwitz, M. A., and Horwitz, L. D. An exochelin of Mycobacterium tuberculosis reversibly arrests growth of human vascular smooth muscle cells in vitro. J. Biol. Chem., 275: 17821-17826, 2000.
11. Pahl, P. M. B., Horwitz, M. A., Horwitz, K. B., and Horwitz, L. D. Desferri-exochelin induces death by apoptosis in human breast cancer cells but does not kill normal breast cells. Breast Cancer Res. Treat., 69: 69-79, 2001.
12. Bruick, R. K. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc. Natl. Acad. Sci. USA, 97: 9082-9087, 2000.
13. Wood, S. M., Wiesener, M. S., Yeates, K. M., Okada, N., Pugh, C. W., Maxwell, P. H., and Ratcliffe, P. J. Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 α-subunit (HIF-1α). Characterization of hif-1α-dependent and -independent hypoxia-inducible gene expression. J. Biol. Chem., 273: 8360-8368, 1998.
14. Sowter, H. M., Ratcliffe, P. J., Watson, P., Greenberg, A. H., and Harris, A. L. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res., 61: 6669-6673, 2001.
15. Koong, A. C., Denko, N. C., Hudson, K. M., Schindler, C., Swiersz, L., Koch, C., Evans, S., Ibrahim, H., Le, Q. T., Terris, D. J., and Giaccia, A. J. Candidate genes for the hypoxic tumor phenotype. Cancer Res., 60: 883-887, 2000.
16. Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W., and Giaccia, A. J. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature (Lond.), 379: 88-91, 1996.
17. Dong, Z., Venkatachalam, M. A., Wang, J., Patel, Y., Saikumar, P., Semenza, G. L., Force, T., and Nishiyama, J. Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia: HIF-1-independent mechanisms. J. Biol. Chem., 276: 18702-18709, 2001.
18. Maxwell, P. H., Wiesener, M. S., Chang, G. W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., and Ratcliffe, P. J. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature (Lond.), 399: 271-275, 1999.