메뉴 건너뛰기




Volumn 51, Issue 12, 2002, Pages 3486-3491

Mechanisms of the triglyceride- and cholesterol-lowering effect of fenofibrate in hyperlipidemic type 2 diabetic patients

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; FENOFIBRATE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LOW DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MESSENGER RNA; SCAVENGER RECEPTOR; TRIACYLGLYCEROL;

EID: 0036894367     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.12.3486     Document Type: Article
Times cited : (120)

References (46)
  • 1
    • 0034106942 scopus 로고    scopus 로고
    • Regulation of lipid and lipoprotein metabolism by PPAR activators
    • Gervois P, Torra I, Fruchart J, Staels B: Regulation of lipid and lipoprotein metabolism by PPAR activators. Clin Chem Lab Med 38:3-11, 2000
    • (2000) Clin Chem Lab Med , vol.38 , pp. 3-11
    • Gervois, P.1    Torra, I.2    Fruchart, J.3    Staels, B.4
  • 2
    • 0030747895 scopus 로고    scopus 로고
    • Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-α in humans: No alteration in adipose tissue of obese and NIDDM patients
    • Auboeuf D, Rieusset J, Fajas L, Vallier P, Frering V, Riou JP, Staels B, Auwerx J, Laville M, Vidal H: Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-α in humans: No alteration in adipose tissue of obese and NIDDM patients. Diabetes 46:1319-1327, 1997
    • (1997) Diabetes , vol.46 , pp. 1319-1327
    • Auboeuf, D.1    Rieusset, J.2    Fajas, L.3    Vallier, P.4    Frering, V.5    Riou, J.P.6    Staels, B.7    Auwerx, J.8    Laville, M.9    Vidal, H.10
  • 3
    • 0031934477 scopus 로고    scopus 로고
    • Monitoring of PPAR alpha protein expression in human tissue by the use of PPAR alpha specific MAbs
    • Su J, Simmons C, Wisely B, Ellis B, Winegar D: Monitoring of PPAR alpha protein expression in human tissue by the use of PPAR alpha specific MAbs. Hybridoma 17:47-53, 1998
    • (1998) Hybridoma , vol.17 , pp. 47-53
    • Su, J.1    Simmons, C.2    Wisely, B.3    Ellis, B.4    Winegar, D.5
  • 5
    • 0036510359 scopus 로고    scopus 로고
    • Nuclear receptor peroxisome proliferator-activated receptor alpha is expressed in resting murine lymphocytes
    • Jones D, Ding X, Daynes R: Nuclear receptor peroxisome proliferator-activated receptor alpha is expressed in resting murine lymphocytes. J Biol Chem 277:6838-6845, 2002
    • (2002) J Biol Chem , vol.277 , pp. 6838-6845
    • Jones, D.1    Ding, X.2    Daynes, R.3
  • 7
    • 0020533327 scopus 로고
    • Effects of clofibrate, bezafibrate, fenofibrate and probucol on plasma lipolytic enzymes in normolipidaemic subjects
    • Heller F, Harvengt C: Effects of clofibrate, bezafibrate, fenofibrate and probucol on plasma lipolytic enzymes in normolipidaemic subjects. Eur J Clin Pharmacol 23:57-63, 1983
    • (1983) Eur J Clin Pharmacol , vol.23 , pp. 57-63
    • Heller, F.1    Harvengt, C.2
  • 8
    • 0035900749 scopus 로고    scopus 로고
    • Regulation of lipoprotein lipase by the oxysterol receptors LXR alpha and LXR beta
    • Zhang Y, Repa J, Gauthier K, Mangelsdorf D: Regulation of lipoprotein lipase by the oxysterol receptors LXR alpha and LXR beta. J Biol Chem 276:43018-43024, 2001
    • (2001) J Biol Chem , vol.276 , pp. 43018-43024
    • Zhang, Y.1    Repa, J.2    Gauthier, K.3    Mangelsdorf, D.4
  • 9
    • 0024474642 scopus 로고
    • Apolipoproteins C-II C-III metabolism in hypertryglyceridemic patients: Effect of a drastic triglyceride reduction by combined diet restriction and fenofibrate administration
    • Malmendier C, Lontie J, Delcroix C, Dubois D, Magot T, De Roy L: Apolipoproteins C-II and C-III metabolism in hypertryglyceridemic patients: Effect of a drastic triglyceride reduction by combined diet restriction and fenofibrate administration. Atherosclerosis 77:139-149, 1989
    • (1989) Atherosclerosis , vol.77 , pp. 139-149
    • Malmendier, C.1    Lontie, J.2    Delcroix, C.3    Dubois, D.4    Magot, T.5    De Roy, L.6
  • 10
    • 0035924635 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha activation and high-density lipoprotein metabolism
    • Fruchart J: Peroxisome proliferator-activated receptor alpha activation and high-density lipoprotein metabolism. Am J Cardiol 88 (Suppl.):24N-29N, 2001
    • (2001) Am J Cardiol , vol.88 , Issue.SUPPL.
    • Fruchart, J.1
  • 13
    • 0034672677 scopus 로고    scopus 로고
    • Cellular and physiological roles of SR-BI, a lipoprotein receptor which mediates selective lipid uptake
    • Trigatti B, Rigotti A, Braun A: Cellular and physiological roles of SR-BI, a lipoprotein receptor which mediates selective lipid uptake. Biochim Biophys Acta 1529:276-286, 2000
    • (2000) Biochim Biophys Acta , vol.1529 , pp. 276-286
    • Trigatti, B.1    Rigotti, A.2    Braun, A.3
  • 14
    • 0032797141 scopus 로고    scopus 로고
    • The ABC's of cholesterol efflux
    • Young S, Fielding C: The ABC's of cholesterol efflux. Nat Genet 22:316-318, 1999
    • (1999) Nat Genet , vol.22 , pp. 316-318
    • Young, S.1    Fielding, C.2
  • 17
    • 0019214136 scopus 로고
    • Increased ketonaemia in hyperthyroidism: Evidence for a beta-adrenergic mechanism
    • Beylot M, Riou JP, Bienvenu F, Momex R: Increased ketonaemia in hyperthyroidism: Evidence for a beta-adrenergic mechanism. Diabetologia 19:505-510, 1980
    • (1980) Diabetologia , vol.19 , pp. 505-510
    • Beylot, M.1    Riou, J.P.2    Bienvenu, F.3    Momex, R.4
  • 18
    • 0035049890 scopus 로고    scopus 로고
    • Effects of isoenergetic high-carbohydrate compared with high-fat diets on human cholesterol synthesis and expression of key genes of cholesterol metabolism
    • Vidon C, Boucher P, Cachefo A, Peroni O, Diraison F, Beylot M: Effects of isoenergetic high-carbohydrate compared with high-fat diets on human cholesterol synthesis and expression of key genes of cholesterol metabolism. Am J Clin Nutr 73:878-884, 2001
    • (2001) Am J Clin Nutr , vol.73 , pp. 878-884
    • Vidon, C.1    Boucher, P.2    Cachefo, A.3    Peroni, O.4    Diraison, F.5    Beylot, M.6
  • 20
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipids from animal tissues
    • Folch J, Lees M, Sloane-Stanley GH: A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497-509, 1957
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane-Stanley, G.H.3
  • 21
    • 0031033070 scopus 로고    scopus 로고
    • Measuring lipogenesis and cholesterol synthesis in humans with deuterated water: Use of simple gas chromatography mass spectrometry techniques
    • Diraison F, Pachiaudi C, Beylot M: Measuring lipogenesis and cholesterol synthesis in humans with deuterated water: Use of simple gas chromatography mass spectrometry techniques. J Mass Spectrom 32:81-86, 1997
    • (1997) J Mass Spectrom , vol.32 , pp. 81-86
    • Diraison, F.1    Pachiaudi, C.2    Beylot, M.3
  • 22
    • 4243190715 scopus 로고
    • Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol
    • Morrison WR, Smith L: Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol. J Lipid Res 5:600-608, 1964
    • (1964) J Lipid Res , vol.5 , pp. 600-608
    • Morrison, W.R.1    Smith, L.2
  • 23
    • 0031887281 scopus 로고    scopus 로고
    • Role of human liver lipogenesis and reesterification in triglycerides secretion and in FFA reesterification
    • Diraison F, Beylot M: Role of human liver lipogenesis and reesterification in triglycerides secretion and in FFA reesterification. Am J Physiol 274:E321-E327, 1998
    • (1998) Am J Physiol , vol.274
    • Diraison, F.1    Beylot, M.2
  • 24
    • 0032079888 scopus 로고    scopus 로고
    • Assay of low deuterium enrichment of water by isotopic exchange with [U-13C]acetone and gas chromatography mass spectrometry
    • Yang D, Diraison F, Beylot M, Brunegraber DZ, Samols MA, Anderson VE, Brunenbraber H: Assay of low deuterium enrichment of water by isotopic exchange with [U-13C]acetone and gas chromatography mass spectrometry. Anal Biochem 258:315-321, 1998
    • (1998) Anal Biochem , vol.258 , pp. 315-321
    • Yang, D.1    Diraison, F.2    Beylot, M.3    Brunegraber, D.Z.4    Samols, M.A.5    Anderson, V.E.6    Brunenbraber, H.7
  • 25
    • 0014385564 scopus 로고
    • Isolation of mononuclear cells and granulocytes from human blood: Isolation of mononuclear cells by one centrifugation and of granulcytes by combining centrifugation and sedimentation at 1g
    • Boyum A: Isolation of mononuclear cells and granulocytes from human blood: Isolation of mononuclear cells by one centrifugation and of granulcytes by combining centrifugation and sedimentation at 1g. Scand J Clin Lab Invest 21 (Suppl. 97):77-89, 1968
    • (1968) Scand J Clin Lab Invest , vol.21 , Issue.SUPPL. 97 , pp. 77-89
    • Boyum, A.1
  • 26
    • 0032434850 scopus 로고    scopus 로고
    • Effects of dietary cholesterol on LDL-receptor, HMG-CoA reductase and LDL receptor-related protein (LRP) mRNA expression in healthy humans
    • Boucher P, Lorgeril M, Salen P, Crozier P, Delaye J, Vallon JJ, Geyssant A, Dante R: Effects of dietary cholesterol on LDL-receptor, HMG-CoA reductase and LDL receptor-related protein (LRP) mRNA expression in healthy humans. Lipids 33:1177-1186, 1998
    • (1998) Lipids , vol.33 , pp. 1177-1186
    • Boucher, P.1    Lorgeril, M.2    Salen, P.3    Crozier, P.4    Delaye, J.5    Vallon, J.J.6    Geyssant, A.7    Dante, R.8
  • 27
    • 0031568947 scopus 로고    scopus 로고
    • The use of reverse transcription competitive polymerase chain reaction to investigate the in vivo regulation of gene expression in small tissue samples
    • Auboeuf D, Vidal H: The use of reverse transcription competitive polymerase chain reaction to investigate the in vivo regulation of gene expression in small tissue samples. Anal Biochem 245:141-148, 1997
    • (1997) Anal Biochem , vol.245 , pp. 141-148
    • Auboeuf, D.1    Vidal, H.2
  • 28
    • 0029888309 scopus 로고    scopus 로고
    • In vivo determination of plasma cholesterol and fatty acids synthesis with deuterated water: Determination of the average number of deuterium incorporated
    • Diraison F, Pachiaudi C, Beylot M: In vivo determination of plasma cholesterol and fatty acids synthesis with deuterated water: determination of the average number of deuterium incorporated. Metab Clin Exp 45:817-821, 1996
    • (1996) Metab Clin Exp , vol.45 , pp. 817-821
    • Diraison, F.1    Pachiaudi, C.2    Beylot, M.3
  • 31
    • 0000926146 scopus 로고
    • Interaction between free fatty acids and insulin in the acute control of VLDL production in humans
    • Lewis G, Uffelman K, Szeto L, Weller B, Steiner G: Interaction between free fatty acids and insulin in the acute control of VLDL production in humans. J Clin Invest 96:135-140, 1995
    • (1995) J Clin Invest , vol.96 , pp. 135-140
    • Lewis, G.1    Uffelman, K.2    Szeto, L.3    Weller, B.4    Steiner, G.5
  • 32
    • 0018864840 scopus 로고
    • Regulation of hepatic fatty acids oxidation and ketone body production
    • McGarry JD, Foster D: Regulation of hepatic fatty acids oxidation and ketone body production. Annu Rev Biochem 49:395-420, 1980
    • (1980) Annu Rev Biochem , vol.49 , pp. 395-420
    • McGarry, J.D.1    Foster, D.2
  • 33
    • 0015394538 scopus 로고
    • Uptake of individual free fatty acids by skeletal muscle and liver in man
    • Hagenfeldt L, Wahren J, Pemon B, Rof L: Uptake of individual free fatty acids by skeletal muscle and liver in man. J Clin Invest 51:2324-2330, 1972
    • (1972) J Clin Invest , vol.51 , pp. 2324-2330
    • Hagenfeldt, L.1    Wahren, J.2    Pemon, B.3    Rof, L.4
  • 34
    • 0016441118 scopus 로고
    • Inhibition of hormone stimulated lipolysis by clofibrate: A possible mechanism for its hypolipidemic action
    • D'Costa M, Angel A: Inhibition of hormone stimulated lipolysis by clofibrate: A possible mechanism for its hypolipidemic action. J Clin Invest 55:138-148, 1975
    • (1975) J Clin Invest , vol.55 , pp. 138-148
    • D'Costa, M.1    Angel, A.2
  • 35
    • 0029994543 scopus 로고    scopus 로고
    • Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
    • Schoonjans K, Staels B, Auwerx J: Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res 37:907-925, 1996
    • (1996) J Lipid Res , vol.37 , pp. 907-925
    • Schoonjans, K.1    Staels, B.2    Auwerx, J.3
  • 36
    • 0035024343 scopus 로고    scopus 로고
    • A potent PPAR alpha agonist stimulates mitochondrial fatty acid beta-oxidation in liver and skeletal muscles
    • Minnich A, Tian N, Byan L, Bilder G: A potent PPAR alpha agonist stimulates mitochondrial fatty acid beta-oxidation in liver and skeletal muscles. Am J Physiol 280:E270-E279, 2001
    • (2001) Am J Physiol , vol.280
    • Minnich, A.1    Tian, N.2    Byan, L.3    Bilder, G.4
  • 37
    • 0036224157 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-α regulates fatty acid utilization in primary human skeletal muscle cells
    • Muoio D, Way J, Tanner C, Winegar DA, Kliewer SA, Houmard JA, Kraus WE, Dohm GL: Peroxisome proliferator-activated receptor-α regulates fatty acid utilization in primary human skeletal muscle cells. Diabetes 51:901-909, 2002
    • (2002) Diabetes , vol.51 , pp. 901-909
    • Muoio, D.1    Way, J.2    Tanner, C.3    Winegar, D.A.4    Kliewer, S.A.5    Houmard, J.A.6    Kraus, W.E.7    Dohm, G.L.8
  • 38
    • 0015950319 scopus 로고
    • Limitations of acetate as a substrate for measuring cholesterol synthesis in liver
    • Dietschy JM, McGarry JD: Limitations of acetate as a substrate for measuring cholesterol synthesis in liver. J Biol Chem 249:52-58, 1974
    • (1974) J Biol Chem , vol.249 , pp. 52-58
    • Dietschy, J.M.1    McGarry, J.D.2
  • 39
    • 0028212483 scopus 로고
    • LDL receptor and HMGCoA-reductase gene expression in human mononuclear leukocytes is regulated coordinately and parallels gene expression in liver
    • Powell E, Kroon P: LDL receptor and HMGCoA-reductase gene expression in human mononuclear leukocytes is regulated coordinately and parallels gene expression in liver. J Clin Invest 93:2168-2174, 1994
    • (1994) J Clin Invest , vol.93 , pp. 2168-2174
    • Powell, E.1    Kroon, P.2
  • 41
    • 0034623288 scopus 로고    scopus 로고
    • Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor
    • Costet P, Luo Y, Wang N, Tall A: Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J Biol Chem 275:28240-28245, 2000
    • (2000) J Biol Chem , vol.275 , pp. 28240-28245
    • Costet, P.1    Luo, Y.2    Wang, N.3    Tall, A.4
  • 42
    • 0034637128 scopus 로고    scopus 로고
    • ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR
    • Schwartz K, Lawn R, Wade D: ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR. Biochem Biophys Res Commun 274:794-802, 2000
    • (2000) Biochem Biophys Res Commun , vol.274 , pp. 794-802
    • Schwartz, K.1    Lawn, R.2    Wade, D.3
  • 44
    • 0035816609 scopus 로고    scopus 로고
    • The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor
    • Luo Y, Liang C, Tall A: The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor. J Biol Chem 276:24767-27773, 2001
    • (2001) J Biol Chem , vol.276 , pp. 24767-27773
    • Luo, Y.1    Liang, C.2    Tall, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.