N-glucuronidation of nicotine and cotinine in human: Formation of cotinine glucuronide in liver microsomes and lack of catalysis by 10 examined UDP-glucuronosyltransferases

Drug Metabolism and Disposition

Volumn 30, Issue 9, 2002, Pages 991-996

  Ghosheh, Omar ^a   Hawes, Edward M ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COTININE; COTININE GLUCURONIDE; GLUCURONOSYLTRANSFERASE; NICOTINE; RECOMBINANT ENZYME; TRIFLUOPERAZINE; UNCLASSIFIED DRUG; COTININE N GLUCURONIDE; COTININE N-GLUCURONIDE; DRUG DERIVATIVE; GLUCURONIC ACID; GLUCURONIDE; NICOTINE N GLUCURONIDE; NICOTINE N-GLUCURONIDE; RECOMBINANT PROTEIN;

ARTICLE; CATALYSIS; CIGARETTE SMOKING; CONTROLLED STUDY; DRUG GLUCURONIDATION; DRUG METABOLISM; DRUG URINE LEVEL; ENZYME SUBSTRATE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; ISOTOPE LABELING; LIVER METABOLISM; LIVER MICROSOME; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; STANDARD; IN VITRO STUDY; KINETICS; METABOLISM; STEREOISOMERISM;

CATALYSIS; COTININE; GLUCURONATES; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMAN; IN VITRO; KINETICS; MICROSOMES, LIVER; NICOTINE; RECOMBINANT PROTEINS; STEREOISOMERISM; SUPPORT, NON-U.S. GOV'T; HUMANS;

EID: 0036707617     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.9.991     Document Type: Article

References (22)

1. Nicotine metabolic profile in man: Comparison of cigarette smoking and transdermal nicotine
2. Sources of variability in nicotine and cotinine levels with use of nicotine nasal spray, transdermal nicotine and cigarette smoking
3. Comparative N-glucuronidation kinetics of ketotifen and amitriptyline by expressed human UDP-glucuronosyltransferases and liver microsomes
4. Evidence for urinary excretion of glucuronide conjugates of nicotine, cotinine and trans-3′-hydroxycotinine in smokers
5. Characterization of the glucuronide conjugate of cotinine: A previously unidentified major metabolite of nicotine in smokers' urine
6. Enantiomeric purity of nicotine in tobacco smoke condensate
7. Characterization of a probe substrate and an inhibitor of UDP-glucuronosyltransferase IA4 activity in human liver microsomes and cDNA-expressed UGT-enzymes
8. Formation of the quaternary ammoniumlinked glucuronide of nicotine in human liver microsomes: Identification and stereoselectivity in the kinetics
9. Expressed human UGT1.4 protein catalyzes the formation of quaternary ammonium-linked glucuronides
10. Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3
11. Glucuronidation of amines and hydroxylated xenobiotics and endobiotics catalyzed by expressed human UGT1.4 protein
12. N-Glucuronidation of xenobiotics symposium, glucuronidation of amine substrates by purified and expressed UDP-glucuronosyltransferase proteins [ASPET Symposium]
13. A study of the optical activity of smoke nicotines
14. Protein measurement with the Folin phenol reagent
15. Synthesis and characterization of quaternary ammonium-linked glucuronide metabolites of drugs with aliphatic tertiary amine group
16. A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes
17. Characterization of multiple products of cytochrome P450 2A6-catalyzed cotinine metabolism
18. Role of human cytochrome P450 2A6 in C-oxidation of nicotine
19. Characterization of CYP 2A6 involved in 3′-hydroxylation of cotinine in human liver microsomes
20. Human UDP-glucuronosyltransferases: Metabolism, expression and disease
21. Synthesis and identification of the quaternary ammonium-linked glucuronide of 1-phenylimidazole in human liver microsomes and investigation of the human UDP-glucuronosyltransferases involved
22. Quaternary ammonium-linked glucuronidation of 1-substituted imidazoles: Studies of human UDP-glucuronosyltransferases involved and substrate specificities