A 13-week subchronic intravaginal toxicity study of the novel broad-spectrum anti-HIV and spermicidal agent, N-[2-(1-cyclohexenyl)ethyl]-N′-[2-(5-bromopyridyl)]-thiourea (PHI-346) in mice

Toxicologic Pathology

Volumn 30, Issue 6, 2002, Pages 687-695

  D'Cruz, Smond J ^a,b   Waurzyniak, Barbara ^a   Uckun, Fatih M ^a  

^a PARKER HUGHES INSTITUTE   (United States)

^b Paradigm Pharmaceuticals   (United States)

Author keywords

13 week intravaginal; HIV AIDS; Microbicide; Nonnucleoside inhibitor; Spermicide

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; N [2 (1 CYCLOHEXENYL)ETHYL] N' [2 (5 BROMOPYRIDYL)]THIOUREA; PHI 346; RNA DIRECTED DNA POLYMERASE INHIBITOR; SPERMICIDAL AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CHEMISTRY; CONTROLLED STUDY; DRUG FORMULATION; FEMALE; HISTOPATHOLOGY; HUMAN IMMUNODEFICIENCY VIRUS 1; MICROEMULSION; MOUSE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; SURVIVAL; VAGINA DISEASE; WEIGHT GAIN;

ADMINISTRATION, INTRAVAGINAL; AMINOPYRIDINES; ANIMALS; ANTI-HIV AGENTS; BODY WEIGHT; CLINICAL CHEMISTRY TESTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FERTILITY; HEMATOLOGIC TESTS; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; MALE; MICE; MICE, INBRED STRAINS; REVERSE TRANSCRIPTASE INHIBITORS; SPERMATOCIDAL AGENTS; THIOUREA; TOXICITY TESTS;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0036867473     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/01926230290168551     Document Type: Article

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