Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors

Journal of Medicinal Chemistry

Volumn 39, Issue 15, 1996, Pages 2971-2979

  Brown, George R ^a   Clarke, David S ^a   Foubister, Alan J ^a   Freeman, Susan ^a   Harrison, Peter J ^a   Johnson, Michael C ^a   Mallion, Keith B ^a   McCormick, John ^a   McTaggart, Fergus ^a   Reid, Alan C ^a   Smith, Graham J ^a   Taylor, Melvyn J ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 3 [4 (4 PYRIDYL)PHENYL]QUINUCLIDINE; 3 QUINUCLIDINOL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METOPROLOL; MEVALONIC ACID; QUINUCLIDINE DERIVATIVE; SQUALENE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHOLESTEROL SYNTHESIS; DOSE RESPONSE; DRUG POTENCY; DRUG SYNTHESIS; HYPERCHOLESTEROLEMIA; ISCHEMIC HEART DISEASE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICHOLESTEREMIC AGENTS; BINDING SITES; CHOLESTEROL; ENZYME INHIBITORS; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; MEVALONIC ACID; MICROSOMES, LIVER; MOLECULAR STRUCTURE; QUINUCLIDINES; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 8944244053     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950907l     Document Type: Article

References (29)

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