Are nitric oxide synthases new players in the pathophysiology of fulminant hepatic failure?

Journal of Hepatology

Volumn 37, Issue 5, 2002, Pages 678-680

  Moreau, Richard ^a  

^a BEAUJON HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CASPASE 3; CASPASE 8; CASPASE 9; CITRULLINE; CYCLIC GMP; CYTOKINE; FAS LIGAND; GAMMA INTERFERON; GUANYLATE CYCLASE; HEMOPROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ARTHRITIS; COLITIS; EDITORIAL; GENE OVEREXPRESSION; HEMORRHAGIC SHOCK; HEPATITIS B; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIVER FAILURE; MYOCARDITIS; NEPHRITIS; NEUROTRANSMISSION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; ENZYMOLOGY; HUMAN; LIVER; METABOLISM; NOTE;

HUMANS; LIVER; LIVER FAILURE; NITRIC OXIDE SYNTHASE;

EID: 0036845798     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(02)00317-3     Document Type: Editorial

References (31)

1. Marietta MA. Nitric oxide synthase: Aspects concerning structure and catalysis. Cell 1994;78:919-925.
2. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109-142.
3. Davis KL, Martin E, Turko IV, Murad F. Novel effects of nitric oxide. Annu Rev Pharmacol Toxicol 2001;41:203-236.
4. Hobbs AJ, Higgs A, Moncada S. Inhibition of nitric oxide synthase as a potential therapeutic target. Annu Rev Pharmacol Toxicol 1999;39:191-220.
5. Stamler JS. Redox signaling: Nitrosylation and related target interactions of nitric oxide. Cell 1994;78:931-936.
6. Leifeld L, Fielenbach M, Dumoulin F-L, Speidel N, Sauerbruch T, Spengler U. Inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) expression in fulminant hepatic failure. J Hepatol 2002;37:613-619.
7. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U, et al. Tumor necrosis factor α in the pathogenesis of human and murine fulminant hepatic failure. Gastroenterology 2000;119:446-460.
8. Ashkenazi A, Dixit VM. Death receptors: Signaling and modulation. Science 1998;281:1305-1308.
9. Cory S, Adams JM. The Bcl2 family: Regulators of the cellular life-or-death switch. Nat Rev Cancer 2002;2:647-656.
10. Hatano E, Bennett BL, Manning AM, Qian T, Lemasters JJ, Brenner DA. NF-κB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-α- and Fas-mediated apoptosis. Gastroenterology 2001;120:1251-1262.
11. Kim YM, Bombeck CA, Billiar TR. Nitric oxide as a bifunctional regulator of apoptosis. Circ Res 1999;84:253-256.
12. Rai RM, Lee FYJ, Rosen A, Yang SQ, Lin HZ, Koteish A, et al. Impaired liver regeneration in inducible nitric oxide synthase-deficient mice. Proc Natl Acad Sci USA 1998;95:13829-13834.
13. Ou J, Carlos TM, Watkins SC, Saavedra JE, Keefer LK, Kim YM, et al. Differential effects of non-selective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM-1 expression, and neutrophil accumulation during endotoxemia. Nitric Oxide 1997;5:404-416.
14. Mignon A, Rouquet N, Fabre M, Martin S, Pagès JC, Dhainaut JF, et al. LPS challenge in D-galactosamine-sensitized mice accounts for caspase-dependent fulminant hepatitis, not for septic shock. Am J Respir Crit Care Med 1999;159:1308-1315.
15. Mojena M, Hortelano S, Castrillo A, Diaz-Guerra MJ, Garcia-Barchino MJ, Saez GT, et al. Protection by nitric oxide against liver inflammatory injury in animals carrying a nitric oxide synthase-2-transgene. FASEB J 2001;15:583-585.
16. Saavedra JE, Billiar TR, Williams DL, Kim YM, Watkins SC, Keefer LK. Targeting nitric oxide (NO) delivery in vivo. Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-alpha-induced apoptosis and toxicity in the liver. J Med Chem 1997;40:1947-1954.
17. Dimmeler S, Haendeler J, Nehls M, Zeiher AM. Suppression of apoptosis by nitric oxide via inhibition of interleukin-1β-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases. J Exp Med 1997;185:601-607.
18. Kim YM, Talanian RV, Billiar TR. Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms. J Biol Chem 1997;272:31138-31148.
19. Rossig L, Fichtlscherer B, Breitschopf K, Haendeler J, Zeiher AM, Mülsch A, et al. Nitric oxide inhibits caspase-3 by S-nitrosation in vivo. J Biol Chem 1999;274:6823-6826.
20. Mannick JB, Hausladen A, Liu L, Hess DT, Zeng M, Miao QX, et al. Fas-induced caspase denitrosylation. Science 1999;284:651-654.
21. Kim YM, Kim TH, Chung HT, Talanian RV, Yin XM, Billiar TR. Nitric oxide prevents tumor necrosis factor α-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of caspase-8. Hepatology 2000;32:770-778.
22. Fiorucci S, Mencarelli A, Palazzetti B, Del Soldato P, Morelli A, Ignarro LJ. An NO derivative of ursodeoxycholic acid protects against Fas-mediated liver injury by inhibiting caspase activity. Proc Natl Acad Sci USA 2001;98:2652-2657.
23. Li J, Yang S, Billiar TR. Cyclic nucleotides suppress tumor necrosis factor α-mediated apoptosis by inhibiting caspase activation and cytochrome c release in primary hepatocytes via a mechanism independent of Akt activation. J Biol Chem 2000:275:13026-13034.
24. Kim YM, de Vera ME, Watkins SC, Billiar TR. Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-α-induced apoptosis by inducing heat shock protein 70 expression. J Biol Chem 1997;272:1402-1411.
25. Moreau R. Heme oxygenase: Protective enzyme or portal hypertensive molecule? J Hepatol 2001;34:936-939.
26. Hierholzer C, Harbrecht B, Menezes JM, Kane J, MacMicking J, Nathan CF, et al. Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock. J Exp Med 1998;187:917-928.
27. Saas G, Koerber K, Bang R, Guehring H, Tiegs G. Inducible nitric oxide synthase is critical for immune-mediated liver injury in mice. J Clin Invest 2001;107:439-447.
28. Stamler JS, Lamas S, Fang FC. Nitrosylation: The prototypic redox-based signaling mechanism. Cell 2001;106:675-683.
29. Förstermann U, Boissel JP, Kleinert H. Expressional control of the 'constitutive' isoforms of nitric oxide synthase (NOS I and NOS III). FASEB J 1998;12:773-790.
30. Govers R, Rabelink TJ. Cellular regulation of endothelial nitric oxide synthase. Am J Physiol 2001;280:F193-F206.
31. Shaul PW. Regulation of endothelial nitric oxide synthase: Location, location, location. Annu Rev Physiol 2002;64:749-774.