Mitochondrial damage associated with long-term antiretroviral treatment: Associated alteration or causal disorder?

Journal of Acquired Immune Deficiency Syndromes

Volumn 31, Issue 3, 2002, Pages 299-308

  Vittecoq, Daniel ^a   Jardel, Claude ^b   Barthélémy, Cyrille ^b   Escaut, Lélia ^a   Cheminot, Nathalie ^a   Chapin, Sandrine ^b   Sternberg, Damien ^b   Maisonobe, Thierry ^b   Lombès, Anne ^b  

^a HÔPITAL PAUL BROUSSE   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Drugtoxicity; HAART; HIV; Mitochondrial disorders; Mitochondrial DNA

Indexed keywords

ABACAVIR; AMPRENAVIR; ANTIRETROVIRUS AGENT; DELAVIRDINE; DIDANOSINE; EFAVIRENZ; INDINAVIR; LACTIC ACID; LAMIVUDINE; LOPINAVIR; NELFINAVIR; NEVIRAPINE; PROTEINASE INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; STAVUDINE; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; AGED; ARTICLE; CELL DAMAGE; CELL STRUCTURE; CEREBROSPINAL FLUID LEVEL; CORRELATION ANALYSIS; DRUG CYTOTOXICITY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LACTATE BLOOD LEVEL; LACTIC ACIDOSIS; LIPODYSTROPHY; LIVER MITOCHONDRION; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MITOCHONDRIAL MEMBRANE; MUSCLE MITOCHONDRION; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; RESPIRATORY CHAIN; SOUTHERN BLOTTING;

EID: 0036840358     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/00126334-200211010-00005     Document Type: Article

References (40)

1. Carpenter CC, Cooper DA, Fischl MA, et al. Antiretroviral therapy in adults: Updated recommendations of the International AIDS Society-USA Panel. JAMA 2000:283:381-90.
2. Brinkman K, Kakuda TN. Mitochondrial toxicity of nucleoside analogue reverse transcriptase inhibitors: A looming obstacle for long-term antiretroviral therapy? Curr Opin Infect Dis 2000;13:5-11.
3. Carr A, Cooper DA. Adverse effects of antiretroviral therapy. Lancet 2000;356:1423-30.
4. Dalakas MC, Ilia I, Pezeshkpour GH, et al. Mitochondrial myopathy caused by long-term zidov̇udine therapy. N Engl J Med 1990;322:1098-105.
5. Arnaudo E, Dalakas M, Shanske S, et al. Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy. Lancet 1991;337:508-10.
6. Chariot P, Drogou I, de Lacroix-Szmania I, et al. Zidovudineinduced mitochondrial disorder with massive liver steatosis, myopathy, lactic acidosis, and mitochondrial DNA depletion. J Hepatol 1999;30:156-60.
7. Shikuma CM, Hu N, Milne C, et al. Mitochondrial DNA decrease in subcutaneous adipose tissue of HIV-infected individuals with peripheral lipoatrophy. AIDS 2001;15:1801-9.
8. Miro O, Gomez M, Pedrol E, et al. Respiratory chain dysfunction associated with multiple mitochondrial DNA deletions in antiretroviral therapy-related lipodystrophy associated with multiple mitochondrial DNA deletions in antiretroviral therapy-related lipodystrophy. AIDS 2000;14:1855-7.
9. Zaera MG, Miro O, Pedrol E, et al. Mitochondrial involvement in antiretroviral therapy-related lipodystrophy. AIDS 2001;15:1643-51.
10. Brinkman K, ter Hofstede HJM, Burger DM, et al. Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway. AIDS 1998;12:1735-44.
11. John M, Moore CB, James IR, et al. Chronic hyperlactatemia in HIV-infected patients taking antiretroviral therapy. AIDS 2001;15:717-23.
12. Masini A, Scotti C, Calligaro A, et al. Zidovudine-induced experimental myopathy: Dual mechanism of mitochondrial damage. J Neurol Sci 1999;166:131-40.
13. Simon DK, Johns DR. Mitochondrial disorders: Clinical and genetic features. Annu Rev Med 1999;50:111-27.
14. Tanji K, Bonilla E. Neuropathologic aspects of cytochrome c oxidase deficiency. Brain Pathol 2000;10:422-30.
15. Lewis W, Dalakas MC. Mitochondrial toxicity of antiviral drugs. Nat Med 1995;1:417-22.
16. Olivero OA, Shearer GM, Chougnet CA, et al. Incorporation of zidovudine into leukocyte DNA from HIV-1-positive adults and pregnant women, and cord blood from infants exposed in utero. AIDS 1999;13:919-25.
17. Johnson AA, Ray AS, Hanes J, et al. Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase. J Biol Chem 2001;276:40847-57.
18. Lim SE, Copeland WC. Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma. J Biol Chem 2001;276:23616-23.
19. de la Asuncion JG, del Olmo ML, Sastre J, et al. AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria: Prevention by antioxidant vitamins. J Clin Invest 1998;102:4-9.
20. Pan-Zhou XR, Cui L, Zhou XJ, et al. Differential effects of antiretroviral nucleoside analogs on mitochondrial function in HepG2 cells. Antimicrob Agents Chemother 2000;44:496-503.
21. Dubowitz V, Brooke MH. Muscle Biopsy: A Modern Approach. Philadelphia: WB Saunders, 1973.
22. Possekel S, Lombès A, Ogier de Baulny H, et al. Immunohistochemical analysis of muscle cytochrome c oxidase deficiency in children. Histochem 1995;103:59-68.
23. Rustin P, Chretien D, Bourgeron T, et al. Biochemical and molecular investigations in respiratory chain deficiencies. Clin Chim Acta 1994;228:35-51.
24. Moraes CT, Shanske S, Trïtschler HJ, et al. MtDNA depletion with variable tissue expression: A novel genetic abnormality in mitochondrial diseases. Am J Hum Genet 1991;48:492-501.
25. Fromenty B, Manfredi G, Sadlock J, et al. Efficient and specific amplification of identified partial duplications of human mitochondrial DNA by long PCR. Biochem Biophys Acta 1996;1308:222-30.
26. Anderson S, Bankier AT, Barrel BG, et al. Sequence and organization of the human mitochondrial genome. Nature 1981;290: 457-65.
27. Drouin J. Cloning of human mitochondrial DNA in Escherichia coli. J Mol Biol 1980;140:15-34.
28. King MP, Attardi G. Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science 1989;246:500-3.
29. Sternberg D, Danan C, Lombès A, et al. Exhaustive scanning approach to screen all the mitochondrial tRNA genes for mutations and its application to the investigation of 35 independent patients with mitochondrial disorders. Hum Mol Genet 1998;7:33-42.
30. Moraes CT, Ciacci F, Bonilla E, et al. Two novel pathogenic mitochondrial DNA mutations affecting organelle number and protein synthesis. J Clin Invest 1993;92:2906-15.
31. Kogelnik AM, Lott MT, Brown MD, et al. MITOMAP: An update on the status of the human mitochondrial genome database. Nucl Acids Res 1997;25:196-9.
32. Petty RKH, Harding AE, Morgan-Hughes JA. The clinical features of mitochondrial myopathy. Brain 1986;109:915-38.
33. Ferri KF, Jacotot E, Blanco J, et al. Mitochondrial control of cell death induced by HIV-1-encoded proteins. Ann NY Acad Sci 2000;926:149-64.
34. Cossarizza A, Pinti M, Moretti L, et al. Mitochondrial functionality and mitochondrial DNA content in lymphocytes of vertically infected human immunodeficiency virus-positive children with highly active antiretroviral therapy-related lipodystrophy. J Infect Dis 2002;185:299-305.
35. Cote HC, Brumme ZL, Craib KJ, et al. Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients. N Engl J Med 2002;346:811-20.
36. McComsey G, Tan DJ, Lederman M, et al. Analysis of the mitochondrial DNA genome in the peripheral blood leukocytes of HIV-infected patients with or without lipoatrophy. AIDS 2002;16:513-8.
37. Martin JL, Brown CE, Matthews-Davis N, et al. Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis. Antimicrob Agents Chemother 1994;38:2743-9.
38. Benbrik E, Chariot P, Bonavaud S, et al. Cellular and mitochondrial toxicity of zidovudine (AZT), didanosine (ddI) and zalcitabine (ddC) on cultured human muscle cells. J Neurol Sci 1997;149:19-25.
39. Van Goethem G, Dermaut B, Lofgren A, et al. Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions. Nat Genet 2001;28:211-2.
40. Barthélémy C, Ogier de Baulny H, Diaz J, et al. Mitochondrial DNA depletion: DNA copy number and compensation in late onset cases. Ann Neurol 2001;49:607-17.