Synthesis, structure-activity relationships, and pharmacokinetic properties of dihydroorotate dehydrogenase inhibitors: 2-cyano-3-cyclopropyl- 3-hydroxy. N-[3'-methyl-4'-(trifluoromethyl)phenyl]propenamide and related compounds

Journal of Medicinal Chemistry

Volumn 39, Issue 23, 1996, Pages 4608-4621

  Kuo, Elizabeth A ^a   Hambleton, Philip T ^a   Kay, David P ^a   Evans, Phillip L ^a   Matharu, Saroop S ^a   Little, Edward ^a   McDowall, Neil ^a   Jones, C Beth ^a   Hedgecock, Charles J R ^a   Yea, Christopher M ^a   Chan, A W Edith ^a   Hairsine, Peter W ^a   Ager, Ian R ^a   Tully, W Roger ^a   Williamson, Richard A ^a   Westwood, Robert ^a,b  

^a Hoechst Roussel Ltd   (United Kingdom)

^b SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYANO 3 CYCLOPROPYL 3 HYDROXY N [3' METHYL 4' (TRIFLUOROMETHYL)PHENYL]PROPENAMIDE; ANTIRHEUMATIC AGENT; DIHYDROOROTATE DEHYDROGENASE; LEFLUNOMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; OXIDOREDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DRUG HALF LIFE; DRUG POTENCY; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; STRUCTURE ACTIVITY RELATION;

ACRYLAMIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, EXPERIMENTAL; ENZYME INHIBITORS; FEMALE; HYPERSENSITIVITY, DELAYED; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, INBRED DBA; OXIDOREDUCTASES; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; RATS; RATS, WISTAR; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 10544236523     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9604437     Document Type: Article

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