Ocular penetration of acyclovir and its peptide prodrugs valacyclovir and val-valacyclovir following systemic administration in rabbits: An evaluation using ocular microdialysis and LC-MS

Current Eye Research

Volumn 25, Issue 4, 2002, Pages 243-252

  Dias, Clapton ^a   Nashed, Yasser ^a   Atluri, Harisha ^a   Mitra, Ashim ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

Acyclovir; LCMS; Ocular microdialysis; Peptide prodrugs; Valacyclovir

Indexed keywords

ACICLOVIR; PRODRUG; UNCLASSIFIED DRUG; VALACICLOVIR; VALVALACYCLOVIR;

ANIMAL EXPERIMENT; ANTERIOR EYE SEGMENT; AQUEOUS HUMOR; AREA UNDER THE CURVE; ARTICLE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG PENETRATION; DRUG TRANSPORT; EVALUATION; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MEAN RESIDENCE TIME; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RABBIT; VITREOUS BODY;

ACYCLOVIR; ANIMALS; ANTIVIRAL AGENTS; AQUEOUS HUMOR; AREA UNDER CURVE; CHROMATOGRAPHY, LIQUID; DIPEPTIDES; EVALUATION STUDIES; EYE; MALE; MASS SPECTROMETRY; MICRODIALYSIS; MODELS, ANIMAL; OCULAR PHYSIOLOGY; PRODRUGS; RABBITS; TIME FACTORS; TRITIUM; VALINE; VITREOUS BODY;

EID: 0036821121     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1076/ceyr.25.4.243.13488     Document Type: Article

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