Vitreous disposition of two acycloguanosine antivirals in the albino and pigmented rabbit models: A novel ocular microdialysis technique

Journal of Ocular Pharmacology and Therapeutics

Volumn 12, Issue 2, 1996, Pages 209-224

  Hughes, Patrick M ^a,b   Krishnamoorthy, Ramesh ^a,c   Mitra, Ashim K ^d  

^a PURDUE UNIVERSITY   (United States)

^b ALLERGAN INC   (United States)

^c BAUSCH AND LOMB   (United States)

^d UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ANTIVIRUS AGENT; GANCICLOVIR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DOSE RESPONSE; DRUG DISPOSITION; DRUG ELIMINATION; DRUG TISSUE LEVEL; INTRAVITREAL DRUG ADMINISTRATION; MICRODIALYSIS; NONHUMAN; PIGMENT EPITHELIUM; RABBIT; VITREOUS BODY;

EID: 0029994811     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.1996.12.209     Document Type: Article

References (29)

1. Darrell, R.W. In Viral diseases of the eye, R.W. Darrell, Ed. (Lea and Febiger, Philadelphia, PA), 1984, pp. 1-5.
2. Meredith, T.A. In Retina, S. J. Ryan, Ed. (Mosby, St.Louis), 1989, pp. 183-188.
3. Brady, S.E., Cohen, E.J., and Fischer, D.H. Diagnosis and treatment of chronic postoperative bacterial endophthalmitis. Ophthalmic Surg., 19:580-584, 1988.
4. Henderly, D.E., Freeman, W.R., and Causey, D.M. Cytomegalovirus retinitis and response to therapy with ganciclovir. Ophthalmology, 94:425-434, 1987.
5. Freeman, W.R. and O'Connor, G.R. Acquired immune deficiency syndrome retinopathy, pneumocystis, and cotton wool spots. Am. J. Ophthalmol., 98:235-237, 1984.
6. Peyman, G.A. and Schulman, J.A. Intravitreal drug therapy. Jpn. J. Ophthalmol., 33:392-404, 1989.
7. Jabs, D.A., Enger, C., and Bartlett, J.G. Cytomegalovirus retinitis and acquired immunodeficiency syndrome. Arch. Ophthalmol., 107:75-80, 1989.
8. Pepose, J.S., Holland, G.N., Nestor, M.S., Cochran, A.J., and Foos, R.Y. AIDS pathogenic mechanisms in ocular disease. Ophthalmology. 92:472-484, 1985.
9. Holland, G.N., Sidikaro, Y., and Kreiger, A.E. Treatment of cytomegalovirus retinopathy with ganciclovir. Ophthalmology. 94:815-823, 1987.
10. D'Amico, D.J., Gaspers-Velu, L., Libert, J., Shanks, E., Schrooyen, M., Hanninen, L.A., and Kenyon, K.R. Comparative toxicity of intravitreal aminoglycoside antibiotics. Am. J. Ophthalmol., 100:264-275, 1985.
11. Ussery, P.M., Gibson, S.R., Conklin, R.H., et al. BW B759U treatment of cytomegalovirus retinitis in patients with AIDS: a 29 patient experience. Programs and abstracts of the III International Conference on AIDS. Paris, France, 1986, pp. Abstract No. 153.
12. Ussery, F.M., Gibson, S.R., Conklin, R.H., et al. Intravitreal ganciclovir (BW B759U) in the management of cytomegalovirus retinitis. Program and abstracts of the III International Conference on AIDS. Washington, D.C., USA, 1987, pp. Abstract No.217.
13. Daikos, G.L., Pulido, J., Kathpalia, S.B., and Jackson, G.G. Intravenous and intraocular ganciclovir for CMV retinitis in patients with AIDS or chemotherapeutic immunosuppression. Br. J. Ophthalmol., 72:521-524, 1988.
14. Henry, K., Cantrill, H., and Fletcher, C. Use of intravitreal ganciclovir for cytomegalovirus retinitis in a patient with AIDS. Am. J. Ophthalmol., 103:17-23, 1987.
15. Akula, S.K., Ma, P.E., Peyman, G.A., Rahimy, M.H., Hyslop, N.E., Janney, A., and Ashton, P. Treatment of cytomegalovirus retinitis with intravitreal injection of liposome encapsulated ganciclovir in a patient with AIDS. Br. J. Ophthalmol., 78:677-680, 1994.
16. Schulman, J., Peyman, G.A., Horton, M.B., Liu, J., Fiscella, R., Pulido, J., Barber, J.C., and de Miranda, P. Intraocular 9-[2-hydroxy-1-(hydroxymethyl) Ethoxy] methylguanine levels after intravitreal and subconjunctival administration. Ophth. Surgery. 17:429-433, 1986.
17. Heery, S. and Hollows, F. High dose intravitreal ganciclovir for cytomegaloviral retinitis. Aust. N. Z. J. Ophthalmol., 17:405-408, 1989.
18. Shikaba, S., Assil, K.K., Listhaus, A.D., et al. Evaluation of retinal toxicity and liposome encapsulation of the anti-CMV drug 2′-nor-cyclic GMP. Invest. Ophthalmol. Vis. Sci. 34:2903-2910, 1993.
19. Cantrill, H.L., Henry, K., Melrose, N.H., Knobloch, W.H., Ramsay, R.C., and Balfour, H.H. Treatment of cytomegalovirus retinitis with intravitreal ganciclovir. Ophthalmology. 96:367-374, 1989.
20. Waga, J., Ohta, A., and Ehinger, B. Intraocular microdialysis with permanently implanted probes in rabbit. Acta Ophthalmologica. 69:618-624, 1991.
21. Salamoun, J., Sprta, V., Sladek, T., and Smrz, M., Determination of acyclovir in plasma by column liquid chromatography with fluorescence detection. J. Chromat., 420:197-202, 1987.
22. Patil, P.N., Shimada, K., Feller, D.R., and Malspeis, L. Accumulation of 14C-ephedrine by the pigmented and non-pigmented iris. J. Pharmacol. Exp. Therap., 188:342-352, 1974.
23. Benveniste, H. and Huttemeir, P.C. Microdialysis: Theory and application. Prog. Neurobiol., 35: 195-215, 1990.
24. Amberg, G. and Linderfs, N. Intracerebral microdialysis. II. Mathematical studies of diffusion kinetics. J. Pharmacol. Meth., 22:157-183, 1989.
25. Maurice, D.M. The exchange of sodium between the vitreous body and the blood and aqueous humor. J. Physiol., 137:119-125, 1957.
26. Maurice, D.M. Protein dynamics in the eye studied with labelled proteins. Am. J. Ophthalmol., 49: 361-367, 1959.
27. Rubinow, S.L. In Introduction to Mathematical Biology, (Wiley, NY), 1975.
28. Cunha-Vaz, J. and Maurice, D.M., The active transport of fluorescein by the retinal vessels and the retina. J. Physiol., 191:467-486, 1967.
29. Maurice, D.M. and Mishrma, S. In Handbook of Experimental Pharmacology: Pharmacology of the eye, M.L. Sears, Ed. Vol. 69, Springer-Verlag, Berlin-Heidelberg, 1986, pp. 19-116.