메뉴 건너뛰기




Volumn 13, Issue 5, 2002, Pages 418-423

Production of clinical-grade recombinant adeno-associated virus vectors

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; NUCLEOTIDE; PLASMID VECTOR; RECOMBINANT DNA; TRANSMEMBRANE CONDUCTANCE REGULATOR; VIRUS PROTEIN; VIRUS VECTOR;

EID: 0036811528     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0958-1669(02)00369-5     Document Type: Review
Times cited : (50)

References (57)
  • 2
    • 85053979233 scopus 로고
    • Adeno-associated viruses of humans
    • J.R. Pattison. CRC Press
    • Blacklow N.R. Adeno-associated viruses of humans. Pattison J.R. Parvoviruses and Human Disease. 1988;165-174 CRC Press.
    • (1988) Parvoviruses and Human Disease , pp. 165-174
    • Blacklow, N.R.1
  • 3
    • 0025820474 scopus 로고
    • A subset of herpes simplex virus replication genes provides helper functions for productive adeno-associated virus replication
    • Weindler F.W., Heilbronn R. A subset of herpes simplex virus replication genes provides helper functions for productive adeno-associated virus replication. J Virol. 65:1991;2476-2483.
    • (1991) J Virol , vol.65 , pp. 2476-2483
    • Weindler, F.W.1    Heilbronn, R.2
  • 4
    • 0025906036 scopus 로고
    • Acquisition of the human adeno-associated virus type-2 rep gene by human herpesvirus type-6
    • Thomson B.J., Efstathiou S., Honess R.W. Acquisition of the human adeno-associated virus type-2 rep gene by human herpesvirus type-6. Nature. 351:1991;78-80.
    • (1991) Nature , vol.351 , pp. 78-80
    • Thomson, B.J.1    Efstathiou, S.2    Honess, R.W.3
  • 5
    • 0023947989 scopus 로고
    • DNA amplification of adeno-associated virus as a response to cellular genotoxic stress
    • Yakinoglu A.O., Heilbronn R., Burkle A., Schlehofer J.R., zur Hausen H. DNA amplification of adeno-associated virus as a response to cellular genotoxic stress. Cancer Res. 48:1988;3123-3129.
    • (1988) Cancer Res , vol.48 , pp. 3123-3129
    • Yakinoglu, A.O.1    Heilbronn, R.2    Burkle, A.3    Schlehofer, J.R.4    Zur Hausen, H.5
  • 6
    • 0025362618 scopus 로고
    • The AAV origin binding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity
    • Im D.S., Muzyczka N. The AAV origin binding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity. Cell. 61:1990;447-457.
    • (1990) Cell , vol.61 , pp. 447-457
    • Im, D.S.1    Muzyczka, N.2
  • 8
    • 0028307303 scopus 로고
    • Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA
    • Weitzman M.D., Kyostio S.R., Kotin R.M., Owens R.A. Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA. Proc Natl Acad Sci USA. 91:1994;5808-5812.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5808-5812
    • Weitzman, M.D.1    Kyostio, S.R.2    Kotin, R.M.3    Owens, R.A.4
  • 9
    • 0028916052 scopus 로고
    • Asymmetric replication in vitro from a human sequence element is dependent on adeno-associated virus Rep protein
    • Urcelay E., Ward P., Wiener S.M., Safer B., Kotin R.M. Asymmetric replication in vitro from a human sequence element is dependent on adeno-associated virus Rep protein. J Virol. 69:1995;2038-2046.
    • (1995) J Virol , vol.69 , pp. 2038-2046
    • Urcelay, E.1    Ward, P.2    Wiener, S.M.3    Safer, B.4    Kotin, R.M.5
  • 10
    • 0031014018 scopus 로고    scopus 로고
    • The adeno-associated virus (AAV) Rep protein acts as both a repressor and an activator to regulate AAV transcription during a productive infection
    • Pereira D.J., McCarty D.M., Muzyczka N. The adeno-associated virus (AAV) Rep protein acts as both a repressor and an activator to regulate AAV transcription during a productive infection. J Virol. 71:1997;1079-1088.
    • (1997) J Virol , vol.71 , pp. 1079-1088
    • Pereira, D.J.1    McCarty, D.M.2    Muzyczka, N.3
  • 11
    • 0022451185 scopus 로고
    • Positive and negative autoregulation of the adeno-associated virus type 2 genome
    • Labow M.A., Hermonat P.L., Berns K.I. Positive and negative autoregulation of the adeno-associated virus type 2 genome. J Virol. 60:1986;251-258.
    • (1986) J Virol , vol.60 , pp. 251-258
    • Labow, M.A.1    Hermonat, P.L.2    Berns, K.I.3
  • 12
    • 0024586532 scopus 로고
    • Adeno-associated virus Rep protein synthesis during productive infection
    • Redemann B.E., Mendelson E., Carter B.J. Adeno-associated virus Rep protein synthesis during productive infection. J Virol. 63:1989;873-882.
    • (1989) J Virol , vol.63 , pp. 873-882
    • Redemann, B.E.1    Mendelson, E.2    Carter, B.J.3
  • 13
    • 0031048047 scopus 로고    scopus 로고
    • The cellular transcription factor SP1 and an unknown cellular protein are required to mediate Rep protein activation of the adeno-associated virus p19 promoter
    • Pereira D.J., Muzyczka N. The cellular transcription factor SP1 and an unknown cellular protein are required to mediate Rep protein activation of the adeno-associated virus p19 promoter. J Virol. 71:1997;1747-1756.
    • (1997) J Virol , vol.71 , pp. 1747-1756
    • Pereira, D.J.1    Muzyczka, N.2
  • 14
    • 0024311525 scopus 로고
    • Helper-free stocks of recombinant adeno-associated viruses: Normal integration does not require viral gene expression
    • Samulski R.J., Chang L.S., Shenk T. Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression. J Virol. 63:1989;3822-3828.
    • (1989) J Virol , vol.63 , pp. 3822-3828
    • Samulski, R.J.1    Chang, L.S.2    Shenk, T.3
  • 15
    • 0031278324 scopus 로고    scopus 로고
    • New developments in the generation of Ad-free, high-titer rAAV gene therapy vectors
    • Describes increases in vector yield and improvements in purity by elimination of infectious adenovirus.
    • Ferrari F.K., Xiao X., McCarty D., Samulski R.J. New developments in the generation of Ad-free, high-titer rAAV gene therapy vectors. Nat Med. 3:1997;1295-1297. Describes increases in vector yield and improvements in purity by elimination of infectious adenovirus.
    • (1997) Nat Med , vol.3 , pp. 1295-1297
    • Ferrari, F.K.1    Xiao, X.2    McCarty, D.3    Samulski, R.J.4
  • 16
    • 0032773889 scopus 로고    scopus 로고
    • Titration of AAV-2 particles via a novel capsid ELISA: Packaging of genomes can limit production of recombinant AAV-2
    • Grimm D., Kern A., Pawlita M., Ferrari F., Samulski R., Kleinschmidt J. Titration of AAV-2 particles via a novel capsid ELISA: packaging of genomes can limit production of recombinant AAV-2. Gene Ther. 6:1999;1322-1330.
    • (1999) Gene Ther , vol.6 , pp. 1322-1330
    • Grimm, D.1    Kern, A.2    Pawlita, M.3    Ferrari, F.4    Samulski, R.5    Kleinschmidt, J.6
  • 17
    • 0032212276 scopus 로고    scopus 로고
    • High-titer adeno-associated viral vectors from a Rep/Cap cell line and hybrid shuttle virus
    • Celllinebased approach in which the rAAV vector cassette is delivered in a recombinant adenovirus shuttle.
    • Gao G.P., Qu G., Faust L.Z., Engdahl R.K., Xiao W., Hughes J.V., Zoltick P.W., Wilson J.M. High-titer adeno-associated viral vectors from a Rep/Cap cell line and hybrid shuttle virus. Hum Gene Ther. 9:1998;2353-2362. Celllinebased approach in which the rAAV vector cassette is delivered in a recombinant adenovirus shuttle.
    • (1998) Hum Gene Ther , vol.9 , pp. 2353-2362
    • Gao, G.P.1    Qu, G.2    Faust, L.Z.3    Engdahl, R.K.4    Xiao, W.5    Hughes, J.V.6    Zoltick, P.W.7    Wilson, J.M.8
  • 18
    • 0030458783 scopus 로고    scopus 로고
    • A stable cell line carrying adenovirus-inducible rep and cap genes allows for infectivity titration of adeno-associated virus vectors
    • Describes a cell-line-based approach to the infectious center assay which greatly improves the rigor of quality control.
    • Clark K.R., Voulgaropoulou F., Johnson P.R. A stable cell line carrying adenovirus-inducible rep and cap genes allows for infectivity titration of adeno-associated virus vectors. Gene Ther. 3:1996;1124-1132. Describes a cell-line-based approach to the infectious center assay which greatly improves the rigor of quality control.
    • (1996) Gene Ther , vol.3 , pp. 1124-1132
    • Clark, K.R.1    Voulgaropoulou, F.2    Johnson, P.R.3
  • 19
    • 0033028656 scopus 로고    scopus 로고
    • Production of recombinant adeno-associated virus vectors using a packaging cell line and a hybrid recombinant adenovirus
    • Liu X.L., Clark K.R., Johnson P.R. Production of recombinant adeno-associated virus vectors using a packaging cell line and a hybrid recombinant adenovirus. Gene Ther. 6:1999;293-299.
    • (1999) Gene Ther , vol.6 , pp. 293-299
    • Liu, X.L.1    Clark, K.R.2    Johnson, P.R.3
  • 20
    • 0034218551 scopus 로고    scopus 로고
    • Efficient recombinant adeno-associated virus production by a stable rep-cap HeLa cell line correlates with adenovirus-induced amplification of the integrated rep-cap genome
    • Chadeuf G., Favre D., Tessier J., Provost N., Nony P., Kleinschmidt J., Moullier P., Salvetti A. Efficient recombinant adeno-associated virus production by a stable rep-cap HeLa cell line correlates with adenovirus-induced amplification of the integrated rep-cap genome. J Gene Med. 2:2000;260-268.
    • (2000) J Gene Med , vol.2 , pp. 260-268
    • Chadeuf, G.1    Favre, D.2    Tessier, J.3    Provost, N.4    Nony, P.5    Kleinschmidt, J.6    Moullier, P.7    Salvetti, A.8
  • 21
    • 0036366753 scopus 로고    scopus 로고
    • Recombinant adeno-associated viral vector production using stable packaging and producer cell lines
    • Mathews L.C., Gray J.T., Gallagher M.R., Snyder R.O. Recombinant adeno-associated viral vector production using stable packaging and producer cell lines. Methods Enzymol. 346:2002;393-413.
    • (2002) Methods Enzymol , vol.346 , pp. 393-413
    • Mathews, L.C.1    Gray, J.T.2    Gallagher, M.R.3    Snyder, R.O.4
  • 22
    • 0030827207 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus type 2 replication and packaging is entirely supported by a herpes simplex virus type 1 amplicon expressing Rep and Cap
    • Conway J.E., Zolotukhin S., Muzyczka N., Hayward G.S., Byrne B.J. Recombinant adeno-associated virus type 2 replication and packaging is entirely supported by a herpes simplex virus type 1 amplicon expressing Rep and Cap. J Virol. 71:1997;8780-8789.
    • (1997) J Virol , vol.71 , pp. 8780-8789
    • Conway, J.E.1    Zolotukhin, S.2    Muzyczka, N.3    Hayward, G.S.4    Byrne, B.J.5
  • 23
    • 0033054126 scopus 로고    scopus 로고
    • High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex virus type I vector expressing AAV-2 Rep and Cap
    • Describes a promising new approach, based on herpes virus, which eliminates the need for transfection.
    • Conway J., Rhys C., Zolotukhin I., Zolotukhin S., Muzyczka N., Hayward G., Byrne B. High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex virus type I vector expressing AAV-2 Rep and Cap. Gene Ther. 6:1999;986-993. Describes a promising new approach, based on herpes virus, which eliminates the need for transfection.
    • (1999) Gene Ther , vol.6 , pp. 986-993
    • Conway, J.1    Rhys, C.2    Zolotukhin, I.3    Zolotukhin, S.4    Muzyczka, N.5    Hayward, G.6    Byrne, B.7
  • 24
    • 0033541640 scopus 로고    scopus 로고
    • Highly purified recombinant adeno-associated virus vectors are biologically active and free of detectable helper and wild-type viruses
    • Clark K.R., Liu X., McGrath J.P., Johnson P.R. Highly purified recombinant adeno-associated virus vectors are biologically active and free of detectable helper and wild-type viruses. Hum Gene Ther. 10:1999;1031-1039.
    • (1999) Hum Gene Ther , vol.10 , pp. 1031-1039
    • Clark, K.R.1    Liu, X.2    McGrath, J.P.3    Johnson, P.R.4
  • 26
    • 0035163792 scopus 로고    scopus 로고
    • Isolation of highly infectious and pure adeno-associated virus type 2 vectors with a single-step gravity-flow column
    • Auricchio A., Hildinger M., O'Connor E., Gao G.P., Wilson J.M. Isolation of highly infectious and pure adeno-associated virus type 2 vectors with a single-step gravity-flow column. Hum Gene Ther. 12:2001;71-76.
    • (2001) Hum Gene Ther , vol.12 , pp. 71-76
    • Auricchio, A.1    Hildinger, M.2    O'Connor, E.3    Gao, G.P.4    Wilson, J.M.5
  • 27
    • 0033022953 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield
    • Describes the advantages of column chromatography techniques in terms of present infectious titer.
    • Zolotukhin S., Byrne B.J., Mason E., Zolotukhin I., Potter M., Chesnut K., Summerford C., Samulski R.J., Muzyczka N. Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield. Gene Ther. 6:1999;973-985. Describes the advantages of column chromatography techniques in terms of present infectious titer.
    • (1999) Gene Ther , vol.6 , pp. 973-985
    • Zolotukhin, S.1    Byrne, B.J.2    Mason, E.3    Zolotukhin, I.4    Potter, M.5    Chesnut, K.6    Summerford, C.7    Samulski, R.J.8    Muzyczka, N.9
  • 28
    • 0029843596 scopus 로고    scopus 로고
    • Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector
    • Xiao X., Li J., Samulski R.J. Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector. J Virol. 70:1996;8098-8108.
    • (1996) J Virol , vol.70 , pp. 8098-8108
    • Xiao, X.1    Li, J.2    Samulski, R.J.3
  • 29
    • 0032788451 scopus 로고    scopus 로고
    • Reporter expression persists 1 year after adeno-associated virus-mediated gene transfer to the optic nerve
    • Guy J., Qi X., Muzyczka N., Hauswirth W.W. Reporter expression persists 1 year after adeno-associated virus-mediated gene transfer to the optic nerve. Arch Ophthalmol. 117:1999;929-937.
    • (1999) Arch Ophthalmol , vol.117 , pp. 929-937
    • Guy, J.1    Qi, X.2    Muzyczka, N.3    Hauswirth, W.W.4
  • 30
    • 0029548371 scopus 로고
    • Adeno-associated virus vectors for gene therapy of neurodegenerative disorders
    • During M.J., Leone P. Adeno-associated virus vectors for gene therapy of neurodegenerative disorders. Clin Neurosci. 3:1995;292-300.
    • (1995) Clin Neurosci , vol.3 , pp. 292-300
    • During, M.J.1    Leone, P.2
  • 32
    • 0031456051 scopus 로고    scopus 로고
    • Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats
    • Mandel R.J., Spratt S.K., Snyder R.O., Leff S.E. Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats. Proc Natl Acad Sci USA. 94:1997;14083-14088.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 14083-14088
    • Mandel, R.J.1    Spratt, S.K.2    Snyder, R.O.3    Leff, S.E.4
  • 34
    • 0030997346 scopus 로고    scopus 로고
    • Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors
    • The primary proof-of-concept supporting the potential efficiency and longevity of rAAV-mediated gene delivery to the liver.
    • Snyder R.O., Miao C.H., Patijn G.A., Spratt S.K., Danos O., Nagy D., Gown A.M., Winther B., Meuse L., Cohen L.K., et al. Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors. Nat Genet. 16:1997;270-276. The primary proof-of-concept supporting the potential efficiency and longevity of rAAV-mediated gene delivery to the liver.
    • (1997) Nat Genet , vol.16 , pp. 270-276
    • Snyder, R.O.1    Miao, C.H.2    Patijn, G.A.3    Spratt, S.K.4    Danos, O.5    Nagy, D.6    Gown, A.M.7    Winther, B.8    Meuse, L.9    Cohen, L.K.10
  • 36
    • 0034828903 scopus 로고    scopus 로고
    • Stable therapeutic serum levels of human (-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors
    • Song S., Embury J., Laipis P.J., Berns K.I., Crawford J.M., Flotte T.R. Stable therapeutic serum levels of human (-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors. Gene Ther. 8:2001;1299-1306.
    • (2001) Gene Ther , vol.8 , pp. 1299-1306
    • Song, S.1    Embury, J.2    Laipis, P.J.3    Berns, K.I.4    Crawford, J.M.5    Flotte, T.R.6
  • 38
  • 39
    • 0034026085 scopus 로고    scopus 로고
    • Adeno-associated virus type 5 (AAV5) but not AAV2 binds to the apical surfaces of airway epithelia and facilitates gene transfer
    • Zabner J., Seiler M., Walters R., Kotin R.M., Fulgeras W., Davidson B.L., Chiorini J.A. Adeno-associated virus type 5 (AAV5) but not AAV2 binds to the apical surfaces of airway epithelia and facilitates gene transfer. J Virol. 74:2000;3852-3858.
    • (2000) J Virol , vol.74 , pp. 3852-3858
    • Zabner, J.1    Seiler, M.2    Walters, R.3    Kotin, R.M.4    Fulgeras, W.5    Davidson, B.L.6    Chiorini, J.A.7
  • 40
    • 0029836472 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus (AAV-CFTR) vectors do not integrate in a site-specific fashion in an immortalized epithelial cell line
    • Kearns W.G., Afione S.A., Fulmer S.B., Pang M.C., Erikson D., Egan M., Landrum M.J., Flotte T.R., Cutting G.R. Recombinant adeno-associated virus (AAV-CFTR) vectors do not integrate in a site-specific fashion in an immortalized epithelial cell line. Gene Ther. 3:1996;748-755.
    • (1996) Gene Ther , vol.3 , pp. 748-755
    • Kearns, W.G.1    Afione, S.A.2    Fulmer, S.B.3    Pang, M.C.4    Erikson, D.5    Egan, M.6    Landrum, M.J.7    Flotte, T.R.8    Cutting, G.R.9
  • 41
    • 0035957384 scopus 로고    scopus 로고
    • Effect of DNA-dependent protein kinase on the molecular fate of the rAAV2 genome in skeletal muscle
    • Song S., Laipis P.J., Berns K.I., Flotte T.R. Effect of DNA-dependent protein kinase on the molecular fate of the rAAV2 genome in skeletal muscle. Proc Natl Acad Sci USA. 98:2001;4084-4088.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4084-4088
    • Song, S.1    Laipis, P.J.2    Berns, K.I.3    Flotte, T.R.4
  • 42
    • 0034030443 scopus 로고    scopus 로고
    • Nonrandom transduction of recombinant adeno-associated virus vectors in mouse hepatocytes in vivo: Cell cycling does not influence hepatocyte transduction
    • Miao C.H., Nakai H., Thompson A.R., Storm T.A., Chiu W., Snyder R.O., Kay M.A. Nonrandom transduction of recombinant adeno-associated virus vectors in mouse hepatocytes in vivo: cell cycling does not influence hepatocyte transduction. J Virol. 74:2000;3793-3803.
    • (2000) J Virol , vol.74 , pp. 3793-3803
    • Miao, C.H.1    Nakai, H.2    Thompson, A.R.3    Storm, T.A.4    Chiu, W.5    Snyder, R.O.6    Kay, M.A.7
  • 44
    • 0032490381 scopus 로고    scopus 로고
    • Efficient and persistent gene transfer of AAV-CFTR in maxillary sinus
    • The first published results from an rAAV vector clinical trial.
    • Wagner J.A., Reynolds T., Moran M.L., Moss R.B., Wine J.J., Flotte T.R., Gardner P. Efficient and persistent gene transfer of AAV-CFTR in maxillary sinus. Lancet. 351:1998;1702-1703. The first published results from an rAAV vector clinical trial.
    • (1998) Lancet , vol.351 , pp. 1702-1703
    • Wagner, J.A.1    Reynolds, T.2    Moran, M.L.3    Moss, R.B.4    Wine, J.J.5    Flotte, T.R.6    Gardner, P.7
  • 48
    • 0030902985 scopus 로고    scopus 로고
    • Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus
    • Herzog R.W., Hagstrom J.N., Kung S.H., Tai S.J., Wilson J.M., Fisher K.J., High K.A. Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus. Proc Natl Acad Sci USA. 94:1997;5804-5809.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 5804-5809
    • Herzog, R.W.1    Hagstrom, J.N.2    Kung, S.H.3    Tai, S.J.4    Wilson, J.M.5    Fisher, K.J.6    High, K.A.7
  • 50
    • 0033960160 scopus 로고    scopus 로고
    • Repeat transduction in the mouse lung by using adeno-associated virus vectors with different serotypes
    • Halbert C.L., Rutledge E.A., Allen J.M., Russell D.W., Miller A.D. Repeat transduction in the mouse lung by using adeno-associated virus vectors with different serotypes. J Virol. 74:2000;1524-1532.
    • (2000) J Virol , vol.74 , pp. 1524-1532
    • Halbert, C.L.1    Rutledge, E.A.2    Allen, J.M.3    Russell, D.W.4    Miller, A.D.5
  • 51
    • 0026070440 scopus 로고
    • Targeted integration of adeno-associated virus (AAV) into human chromosome 19. [published erratum appears in EMBO J, 1992. 11:128]
    • Samulski R.J., Zhu X., Xiao X., Brook J.D., Housman D.E., Epstein N., Hunter L.A. Targeted integration of adeno-associated virus (AAV) into human chromosome 19. [published erratum appears in EMBO J, 1992. 11:128]. EMBO J. 10:1991;3941-3950.
    • (1991) EMBO J , vol.10 , pp. 3941-3950
    • Samulski, R.J.1    Zhu, X.2    Xiao, X.3    Brook, J.D.4    Housman, D.E.5    Epstein, N.6    Hunter, L.A.7
  • 52
    • 0031011987 scopus 로고    scopus 로고
    • Adeno-associated virus 2-mediated gene transfer in vivo: Organ-tropism and expression of transduced sequences in mice
    • Ponnazhagan S., Mukherjee P., Yoder M.C., Wang X.S., Zhou S.Z., Kaplan J., Wadsworth S., Srivastava A. Adeno-associated virus 2-mediated gene transfer in vivo: organ-tropism and expression of transduced sequences in mice. Gene. 190:1997;203-210.
    • (1997) Gene , vol.190 , pp. 203-210
    • Ponnazhagan, S.1    Mukherjee, P.2    Yoder, M.C.3    Wang, X.S.4    Zhou, S.Z.5    Kaplan, J.6    Wadsworth, S.7    Srivastava, A.8
  • 54
    • 0034960344 scopus 로고    scopus 로고
    • Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo
    • Nakai H., Yant S.R., Storm T.A., Fuess S., Meuse L., Kay M.A. Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo. J Virol. 75:2001;6969-6976.
    • (2001) J Virol , vol.75 , pp. 6969-6976
    • Nakai, H.1    Yant, S.R.2    Storm, T.A.3    Fuess, S.4    Meuse, L.5    Kay, M.A.6
  • 56
    • 0034712849 scopus 로고    scopus 로고
    • Adeno-associated virus site-specifically integrates into a muscle-specific DNA region
    • Dutheil N., Shi F., Dupressoir T., Linden R.M. Adeno-associated virus site-specifically integrates into a muscle-specific DNA region. Proc Natl Acad Sci USA. 97:2000;4862-4866.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 4862-4866
    • Dutheil, N.1    Shi, F.2    Dupressoir, T.3    Linden, R.M.4
  • 57
    • 0031779697 scopus 로고    scopus 로고
    • Adeno-associated virus vector-mediated transgene integration into neurons and other nondividing cell targets
    • Wu P., Phillips M.I., Bui J., Terwilliger E.F. Adeno-associated virus vector-mediated transgene integration into neurons and other nondividing cell targets. J Virol. 72:1998;5919-5926.
    • (1998) J Virol , vol.72 , pp. 5919-5926
    • Wu, P.1    Phillips, M.I.2    Bui, J.3    Terwilliger, E.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.