Purines and pyrimidines are not involved in NANC relaxant responses in the rabbit vaginal wall

British Journal of Pharmacology

Volumn 137, Issue 4, 2002, Pages 513-521

  Ziessen, Tom ^a   Cellek, Selim ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Nitric oxide; Non adrenergic non cholinergic; Purinergic; Rabbit; Vagina

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; ADENOSINE; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CIBACRON BLUE F3GA; CYCLIC AMP; CYCLIC GMP; GUANETHIDINE; GUANINE NUCLEOTIDE BINDING PROTEIN; N(G) NITROARGININE METHYL ESTER; OMEGA CONOTOXIN GVIA; PHENYLEPHRINE; PURINE; PURINE P2 RECEPTOR; PYRIMIDINE; SCOPOLAMINE; SURAMIN; TETRODOTOXIN; URIDINE DIPHOSPHATE; URIDINE TRIPHOSPHATE;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ELECTRIC FIELD; ENZYME INHIBITION; FEMALE; MUSCLE TONE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PHARMACOLOGICAL STIMULATION; PRIORITY JOURNAL; PROTEIN STABILITY; VAGINA;

ADRENERGIC FIBERS; ANIMALS; CHOLINERGIC FIBERS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MUSCLE RELAXATION; PURINES; PYRIMIDINES; RABBITS; VAGINA;

EID: 0036800651     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704898     Document Type: Article

References (49)

1. American Psychiatric Association (2000). Female sexual arousal disorder, In Diagnostic and Statistical Manual of Mental Disorders. Fourth edition, Text Revision (DSM-IV-TR). pp. 543-544. Washington D.C.: American Psychiatric Association.
2. Bogdanov, Y.D., Wildman, S.S., Clements, M.P., King, B.F. & Burnstock, G. (1998). Molecular cloning and characterization of rat P2Y4 nucleotide receptor. Br. J. Pharmacol., 124, 428-430.
3. Burnstock, G. (1978). A basis for distinguishing two types of purinergic receptor. In Cell Membrane Receptors for Drugs and Hormones: A Multidisciplinary Approach. ed. Straub, R.W., Bolis, L. pp. 107-118. New York: Raven Press.
4. Burnstock, G. & Kennedy, C. (1985). Is there a basis for distinguishing two types of P2-purinoceptor? Gen. Pharmacol., 16, 433-440.
5. Cellek, S., Kasakov, L. & Moncada, S (1996). Inhibition of nitrergic relaxations by a selective inhibitor of the soluble guanylate cyclase, Br. J. Pharmacol., 118, 137-140.
6. Cellek, S. & Moncada, S. (1997). Nitrergic control of peripheral sympathetic responses in the human corpus cavernosum: A comparison with other species. Proc. Natl. Acad. Sci. U.S.A., 94, 8226-8231.
7. Cellek, S. & Moncada, S. (1998). Nitrergic neurotransmission mediates the non-adrenergic non-cholinergic responses in the clitoral corpus cavernosum of the rabbit. Br. J. Pharmacol., 125, 1627-1629.
8. Cellek, S., Ziessen, T.M. & Moncada, S. (1999). Non-adrenergic non-cholinergic responses in the rabbit vaginal wall are mediated by nitrergic neurotransmission. Br. J. Pharmacol., 126, 98P.
9. Charlton, S.J., Brown, C.A., Weisman, G.A., Turner. J.T., Erb, L. & Boarder, M.R. (1996). PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors. Br. J. Pharmacol., 118, 704-710.
10. Communi, D., Gonzalez, N.S., Detheux, M., Brezillon, S., Lannoy, V., Parmentier, M. & Boeynaems. J.M. (2001). Identification of a novel human ADP receptor coupled to G(i). J. Biol. Chem., 276, 41479-41485.
11. Communi, D., Govaerts, C., Parmentier, M. & Boeynaems. J.M. (1997). Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase. J. Biol. Chem., 272, 31969-31973.
12. Communi, D., Motte, S., Boeynaems, J.M. & Pirotton, S. (1996b). Pharmacological characterization of the human P2Y4 receptor, Eur. J. Pharmacol., 317, 383-389.
13. Communi, D., Parmentier, M. & Boeynaems, J.M. (1996a). Cloning, functional expression and tissue distribution of the human P2Y6 receptor. Biochem. Biophys. Res. Commun., 222, 303-308.
14. Crack, B.E., Beukers, M.W., McKechnie, K.C., Ijzerman, A.P. & Leff, P. (1994). Pharmacological analysis of ecto-ATPase inhibition: Evidence for combined enzyme inhibition and receptor antagonism in P2X-purinoceptor ligands. Br. J. Pharmacol., 113, 1432-1438.
15. Daniel. E.E., Crankshaw, J. & Sarna, S. (1979). Prostaglandins and tetrodotoxin-insensitive relaxation of opossum lower esophageal sphincter. Am. J. Physiol., 236, E153-E172.
16. Dunn, P.M. & Blakeley, A.G. (1988). Suramin: A reversible P2-purinoceptor antagonist in the mouse vas deferens. Br. J. Pharmacol., 93, 243-245.
17. Eckstein, F., Cassel, D., Levkovitz, H., Lowe, M. & Selinger, Z. (1979). Guanosine 5′-O-(2-thiodiphosphate). An inhibitor of adenylate cyclase stimulation by guanine nucleotides and fluoride ions. J. Biol. Chem., 254, 9829-9834.
18. Fredholm, B.B., Abbracchio, M.P., Burnstock, G., Dubyak, G.R., Harden, T.K., Jacobson, K.A., Schwabe, U. & Williams, M. (1997). Towards a revised nomenclature for P1 and P2 receptors. Trends Pharmacol. Sci., 18, 79-82.
19. Gillespie, J.S. (1972). The rat anococcygeus muscle and its response to nerve stimulation and to some drugs. Br. J. Pharmacol., 45, 404-416.
20. G-monomethyl-L-arginine on the response of the rat anococcygeus muscle to NANC nerve stimulation. Br. J. Pharmacol., 98, 1080-1082.
21. Goldstein, I. (2000). Female sexual arousal disorder: New insights. Int. J. Impot. Res., 12 (Suppl. 4), S152-S157.
22. Haynes, J.M. (2000). A(2A) adenosine receptor mediated potassium channel activation in rat epididymal smooth muscle. Br. J. Pharmacol., 130, 685-691.
23. G-nitro-arginine and its methyl ester are potent inhibitors of non-adrenergic, non-cholinergic transmission in the rat anococcygeus. Br. J. Pharmacol., 100, 749-752.
24. Hollopeter, G., Jantzen, H.M., Vincent, D., Li, G., England, L., Ramakrishnan, V., Yang, R.B., Nurden, P., Nurden, A., Julius, D. & Conley, P.B. (2001). Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature, 409, 202-207
25. Ignarro, L.J., Bush, P.A., Buga, G.M., Wood, K.S., Fukuto, J.M. & Rajfer, J. (1990). Nitric oxide and cyclicGMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem. Biophys. Res. Commun., 170, 843-850.
26. Ishiguchi, T., Takahashi, T., Itoh, H. & Owyang, C. (2000). Nitrergic and purinergic regulation of the rat pylorus. Am. J. Physiol. Gastrointest. Liver. Physiol., 279, G740-G747.
27. Kaplan, H.S. (1974). The New Sex Therapy: Active Treatment of Sexual Dysfunctions. London: Baillière Tindall.
28. Kim, Y.C., Ji, X., Melman, N., Linden, J. & Jacobson, K.A. (2000). Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors. J. Med. Chem., 43, 1165-1172.
29. King, B.F., Burnstock, G., Boyer, J., Boeynaems, J.M., Weisman, G.A., Kennedy, C., Jacobson, K.A., Humphries, R.G., Abbracchio, M.P., Gachet, C. & Miras-Portugal, M.T. (2000). P2Y receptors. In The IUPHAR Compendium of Receptor Characterization and Classification, 2nd Edition. ed. Girdlestone, D. pp. 306-320. London: IUPHAR Media.
30. Lazarowski, E.R., Rochelle, L.G., O'neal, W.K., Ribeiro, C.M., Grubb, B.R., Zhang, V., Harden, T.K. & Boucher, R.C. (2001). Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder. J. Pharmacol. Exp. Ther., 297, 43-49.
31. Li, C.G. & Rand, M.J. (1989). Evidence for a role of nitric oxide in the neurotransmitter system mediating relaxation of the rat anococcygeus muscle. Clin. Exp. Pharmacol. Physiol., 16, 933-938.
32. Manzini, S., Hoyle, C.H. & Burnstock, G. (1986). An electrophysiological analysis of the effect of reactive blue 2, a putative P2-purinoceptor antagonist, on inhibitory junction potentials of rat caecum. Eur. J. Pharmacol., 127, 197-204.
33. McMurray, G., Dass, N. & Brading, A.F. (1998). Purinoceptor subtypes mediating contraction and relaxation of marmoset urinary bladder smooth muscle. Br. J. Pharmacol., 123, 1579-1586.
34. Nicholas, R.A., Lazarowski, E.R., Watt, W.C., Li, Q., Boyer, J. & Harden, T.K. (1996). Pharmacological and second messenger signalling selectivities of cloned P2Y receptors. J. Auton. Pharmacol., 16, 319-323.
35. Park, K., Goldstein, I., Andry, C., Siroky. M.B., Krane, R.J. & Azadzoi, K.M. (1997). Vasculogenic female sexual dysfunction: the hemodynamic basis for vaginal engorgement insufficiency and clitoral erectile insufficiency [published erratum appears in Int J Impot Res 1998 Mar; 10(1):67]. Int. J. Impot. Res., 9, 27-37.
36. Poucher, S.M., Keddie, J.R., Singh, P., Stoggall, S.M., Caulkett, P.W., Jones, G. & Coll, M.G. (1995). The in vitro pharmacology of ZM 241385, a potent, non-xanthine A2a selective adenosine receptor antagonist. Br. J. Pharmacol., 115, 1096-1102.
37. Ralevic, V. (2001). Mechanism of prolonged vasorelaxation to ATP in the rat isolated mesenteric arterial bed. Br. J. Pharmacol., 132, 685-692.
38. Ralevic, V. (2002). The involvement of smooth muscle P2X receptors in the prolonged vasorelaxation response to purine nucleotides in the rat mesentaeric arterial bed. Br. J. Pharmacol., 135, 1988-1994.
39. Ralevic, V. & Burnstock, G. (1998). Receptors for purines and pyrimidines. Pharmacol. Rev., 50, 413-492.
40. Rees, D.D., Cellek, S., Palmer, R.M. & Moncada, S. (1990). Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: An insight into endotoxin shock. Biochem. Biophys. Res. Commun., 173, 541-547.
41. Robaye, B., Boeynaems, J.M. & Communi, D. (1997). Slow desensitization of the human P2Y6 receptor. Eur. J. Pharmacol., 329, 231-236.
42. Sauzeau, V., Le Jeune, H., Cario-Toumaniantz, C., Vaillant, N., Gadeau, A.P., Desgranges, C., Scalbert, E., Chardin, P., Pacaud, P. & Loirand, G. (2000). P2Y(1), P2Y(2), P2Y(4), and P2Y(6) receptors are coupled to Rho and Rho kinase activation in vascular myocytes. Am. J. Physiol. Heart Circ. Physiol., 278, H1751-H1761.
43. Sellers, L.A., Simon, J., Lundahl, T.S., Cousens, D.J., Humphrey, P.P. & Barnard, E.A. (2001). Adenosine nucleotides acting at the human P2Y1 receptor stimulate mitogen-activated protein kinases and induce apoptosis. J. Biol. Chem., 276, 16379-16390.
44. Stanford, S.J., Gitlin, J.M. & Mitchell, J.A. (2001). Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat. Br. J. Pharmacol., 133, 825-832.
45. 2+ stores in purinergic inhibition. Clin. Exp. Pharmacol. Physiol., 27, 771-779.
46. Van der Ploeg, I., Parkinson, F.E. & Fredholm, B.B. (1992). Effect of pertussis toxin on radioligand binding to rat brain adenosine A1 receptors. J. Neurochem., 58, 1221-1229.
47. Von Kugelgen, I., Haussinger, D. & Starke, K. (1987). Evidence for a vasoconstriction-mediating receptor for UTP, distinct from the P2 purinoceptor, in rabbit ear artery. Naunyn. Schmiedebergs. Arch. Pharmacol., 336, 556-560.
48. Yegutkin, G.G. & Burnstock, G. (2000). Inhibitory effects of some purinergic agents on ecto-ATPase activity and pattern of stepwise ATP hydrolysis in rat liver plasma membranes. Biochim. Biophys. Acta., 1466, 234-244
49. Ziessen, T., Moncada, S. & Cellek, S. (2002). Characterisation of the non-nitrergic NANC relaxation responses in the rabbit vaginal wall. Br. J. Pharmacol., 135, 546-554.