Inhibitory effects of some purinergic agents on ecto-ATPase activity and pattern of stepwise ATP hydrolysis in rat liver plasma membranes

Biochimica et Biophysica Acta - Biomembranes

Volumn 1466, Issue 1-2, 2000, Pages 234-244

  Yegutkin, Gennady G ^a,b   Burnstock, Geoffrey ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

Ecto ATPase; Inhibition; Liver plasma membrane; P2 receptor; Rat

Indexed keywords

ADENOSINE 5' O (2 THIODIPHOSPHATE); ADENOSINE 5' O (3 THIOTRIPHOSPHATE); ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; ALPHA,BETA METHYLENEADENOSINE DIPHOSPHATE; BETA,GAMMA METHYLENEADENOSINE TRIPHOSPHATE; CIBACRON BLUE F3GA; DIADENOSINE POLYPHOSPHATE; DIADENOSINE TETRAPHOSPHATE; PURINE P2 RECEPTOR; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; SURAMIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; LIVER CELL MEMBRANE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ANIMALS; BINDING, COMPETITIVE; CATALYSIS; CELL MEMBRANE; DINUCLEOSIDE PHOSPHATES; ENZYME INHIBITORS; HYDROLYSIS; LIVER; MALE; PYRIDOXAL PHOSPHATE; RATS; RATS, SPRAGUE-DAWLEY; SUBSTRATE SPECIFICITY; SURAMIN; TRIAZINES;

EID: 0034213015     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0005-2736(00)00165-6     Document Type: Article

References (43)

1. 2-purinergic receptors for extracellular ATP and other nucleotides. Am. J. Physiol. 265:1993;C577-C606.
2. Zimmermann H. Biochemistry, localization and functional roles of ecto-nucleotidases in the nervous system. Prog. Neurobiol. 49:1996;589-618.
3. Burnstock G. The past, present and future of purine nucleotides as signalling molecules. Neuropharmacology. 36:1997;1127-1139.
4. Abbracchio M.P., Burnstock G. Purinoceptors: are there families of P2X and P2Y purinoceptors? Pharmacol. Ther. 64:1994;445-475.
5. Fredholm B.B., Abbracchio M.P., Burnstock G., Daly J.W., Harden T.K., Jacobson K.A., Leff P., Williams M. Nomenclature and classification of purinoceptors. Pharmacol. Rev. 46:1994;143-156.
6. 2-purinergic receptors: subtype-associated signaling responses and structure. Annu. Rev. Pharmacol. Toxicol. 35:1995;547-579.
7. J.D. Pearson, Ectonucleotidases: measurement of activities and use of inhibitors, in: D.M. Paton (Ed.), Methods in Pharmacology, Plenum Press, New York, 1985, pp. 83-105.
8. Plesner L. Ecto-ATPases: identities and functions. Int. Rev. Cytol. 158:1995;141-214.
9. Meghji P., Pearson J.D., Slakey L.L. Kinetics of extracellular ATP hydrolysis by microvascular endothelial cells from rat heart. Biochem. J. 308:1995;725-731.
10. Lazarowski E.R., Homolya L., Boucher R.C., Harden T.K. Identification of an ecto-nucleoside diphosphokinase and its contribution to interconversion of P2 receptor agonists. J. Biol. Chem. 272:1997;20402-20407.
11. Grobben B., Anciaux K., Roymans D., Stefan C., Bollen M., Eshmans E.L., Slegers H. An ecto-nucleotide pyrophosphatase is one of the main enzymes involved in the extracellular metabolism of ATP in rat C6 glioma. J. Neurochem. 72:1999;826-834.
12. Che M., Nishida T., Gatmaitan Z., Arias I.M. A nucleoside transporter is functionally linked to ectonucleotidases in rat liver canalicular membrane. J. Biol. Chem. 267:1992;9684-9688.
13. Che M., Gatmaitan Z., Arias I.M. Ectonucleotidases, purine nucleoside transporter, and function of the bile canalicular plasma membrane of the hepatocyte. FASEB J. 11:1997;101-108.
14. Schlosser S.F., Burgstahler A.D., Nathanson M.H. Isolated rat hepatocytes can signal to other hepatocytes and bile duct cells by release of nucleotides. Proc. Natl. Acad. Sci. USA. 93:1996;9948-9953.
15. Roman R.M., Wang Y., Lidofsky S.D., Feranchak A.P., Lomri N., Scharschmidt B.F., Fitz J.G. Hepatocellular ATP-binding cassette protein expression enhances ATP release and autocrine regulation of cell volume. J. Biol. Chem. 272:1997;21970-21976.
16. Keppens S. The complex interaction of ATP and UTP with isolated hepatocytes. How many receptors? Gen. Pharmacol. 24:1993;283-289.
17. 3H]ATP to rat liver plasma membranes and competition by various purinergic agonists and antagonists. Biochim. Biophys. Acta. 1373:1998;227-236.
18. Hourani S.M.O., Chown J.A. The effects of some possible inhibitors of ectonucleotidases on the breakdown and pharmacological effects of ATP in the guinea-pig urinary bladder. Gen. Pharmacol. 20:1989;413-416.
19. 2x-purinoceptor ligands. Br. J. Pharmacol. 113:1994;1432-1438.
20. Ziganshin A.U., Hoyle C.H.V., Ziganshina L.E., Burnstock G. Effects of cyclopiazonic acid on contractility and ecto-ATPase activity in guinea-pig urinary bladder and vas deferens. Br. J. Pharmacol. 113:1994;669-674.
21. 6 glioma cells and RAW 264.7 macrophages. Br. J. Pharmacol. 119:1996;1628-1634.
22. Stout J.G., Kirley T.L. Inhibition of purified chicken gizzard smooth muscle ecto-ATPase by P2 purinoceptor antagonists. Biochem. Mol. Biol. Int. 36:1995;927-934.
23. Beukers M.W., Kerkhof C.J.M., Van Rhee A.M., Ardanuy U., Gurgel C., Widjaja H., Nickel P., Ijzerman A.P., Soudijn W. Suramin analogs, divalent cations and ATPγS as inhibitors of ecto-ATPase. Naunyn Schmiedeberg's Arch. Pharmacol. 351:1995;523-528.
24. 2 purinoceptor agonists, ATPγS, α, β-methylene-ATP, and AMP-PNP, in endothelial cells. Biochem. Biophys. Res. Commun. 233:1997;442-446.
25. Kenakin T.P., Beek D. Self-cancellation of drug properties by a mode of organ selectivity: the antimuscarinic effects of ambenonium. J. Pharmacol. Exp. Ther. 232:1985;732-740.
26. Dorling P.R., Le Page R.N. A rapid high yield method for the preparation of rat liver cell plasma membranes. Biochim. Biophys. Acta. 318:1973;33-44.
27. Markwell M.A.K., Haas S.M., Bieber L.L., Tolbert N.E. A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Analyt. Biochem. 87:1978;206-210.
28. Norman G.A., Follett M.J., Hector D.A. Quantitative thin-layer chromatography of ATP and the products of its degradation in meat tissue. J. Chromatogr. 90:1974;105-111.
29. Lin S.-H. Liver plasma membrane ecto-ATPase: purification, localization, cloning and functions. Ann. New York Acad. Sci. 603:1990;394-400.
30. Stefan C., Stalmans W., Bollen M. Growth-related expression of the ectonucleotide pyrophosphatase PC-1 in rat liver. Hepatology. 28:1998;1497-1503.
31. Stefan C., Gijsberg R., Stalmans W., Bollen M. Differential regulation of the expression of nucleotide pyrophosphatases/phosphodiesterases in rat liver. Biochim. Biophys. Acta. 1450:1999;45-52.
32. Yegutkin G.G., Yakubovskii S.M., Gatsko G.G. Alteration of 5′-nucleotidase properties in rat adipose and liver plasma membranes after 1 Gy whole-body γ-irradiation. Int. J. Radiat. Biol. 63:1993;583-587.
33. Stout J.G., Kirley T.L. Control of cell membrane ecto-ATPase by oligomerization state intermolecular cross-linking modulates ATPase activity. Biochemistry. 35:1996;8289-8298.
34. Lewis-Carl S., Kirley T.L. Immunolocalization of the ecto-ATPase and ecto-apyrase in chicken gizzard and stomach. J. Biol. Chem. 272:1997;23645-23652.
35. Kegel B., Braun N., Heine P., Maliszewski C.R., Zimmermann H. An ecto-ATPase and an ecto-ATP diphosphohydrolase are expressed in rat brain. Neuropharmacology. 36:1997;1189-1200.
36. Esch J.S. II, Sevigny J., Kaczmarek E., Siegel J.B., Imai M., Koziak K., Beaudoin A.R., Robson S.C. Structural elements and limited proteolysis of CD39 influence ATP diphosphohydrolase activity. Biochemistry. 38:1999;2248-2258.
37. Smith T.M., Kirley T.L. Site-directed mutagenesis of a human brain ecto-apyrase evidence that the E-type ATPases are related to the actin/heat shock 70/sugar kinase superfamily. Biochemistry. 38:1999;321-328.
38. Welford L.A., Cusack N.J., Hourani S.M.O. The structure-activity relationships of ectonucleotidases and of excitatory P2-purinoceptors: evidence that dephosphorylation of ATP analogues reduces pharmacological potency. Eur. J. Pharmacol. 141:1987;123-130.
39. Craik K.M., McLennan A.G., Fisher M.J. Adenine dinucleotide-mediated activation of glycogen phosphorylase in isolated liver cells. Cell. Signal. 5:1993;89-96.
40. Keppens S. Effects of diadenosine triphosphate and diadenosine tetraphosphate on rat liver cells. Differences and similarities with ADP and ATP. Biochem. Pharmacol. 52:1996;441-445.
41. Pearson J., Cusack N.J. Investigation of the preferred Mg(II)-adenine-nucleotide complex at the active site of ectonucleotidases in intact vascular cells using phosphorothioate analogues of ADP and ATP. Eur. J. Biochem. 151:1985;373-375.
42. Cohn M. Structural and chemical properties of ATP and its metal complexes in solution. Ann. New York Acad. Sci. 603:1990;151-164.
43. Yegutkin G.G., Burnstock G. Steady-state binding of adenine nucleotides ATP, ADP and AMP to rat liver and adipose plasma membranes. J. Rec. Sign. Transduc. Res. 19:1999;437-448.